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G6PD Baculovirus Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS204787

Glucose-6-phosphate dehydrogenase (G6PD) is the rate-limiting enzyme of the pentose phosphate pathway, a metabolic pathway that supplies reducing energy to cells by maintaining the level of NADPH. G6PD converts glucose-6-phosphate into… More details

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Product Overview

Online Datasheet in PDF
Product Name
G6PD, Active Protein
Full Product Name
G6PD, 1-515aa, Human, His tag, Baculovirus (Bioactivity Validated)
Product Gene Name
G6PD active protein
Product Synonym Names
glucose-6-phosphate 1-dehydrogenase; G6PD1
Sequence
MGSSHHHHHH SSGLVPRGSH MAEQVALSRT QVCGILREEL FQGDAFHQSD THIFIIMGAS GDLAKKKIYP TIWWLFRDGL LPENTFIVGY ARSRLTVADI RKQSEPFFKA TPEEKLKLED FFARNSYVAG QYDDAASYQR LNSHMNALHL GSQANRLFYL ALPPTVYEAV TKNIHESCMS QIGWNRIIVE KPFGRDLQSS DRLSNHISSL FREDQIYRID HYLGKEMVQN LMVLRFANRI FGPIWNRDNI ACVILTFKEP FGTEGRGGYF DEFGIIRDVM QNHLLQMLCL VAMEKPASTN SDDVRDEKVK VLKCISEVQA NNVVLGQYVG NPDGEGEATK GYLDDPTVPR GSTTATFAAV VLYVENERWD GVPFILRCGK ALNERKAEVR LQFHDVAGDI FHQQCKRNEL VIRVQPNEAV YTKMMTKKPG MFFNPEESEL DLTYGNRYKN VKLPDAYERL ILDVFCGSQM HFVRSDELRE AWRIFTPLLH QIELEKPKPI PYIYGSRGPT EADELMKRVG FQYEGTYKWV NPHKL
Host
Baculovirus
Form/Format
Liquid. 20mM Tris-HCl Buffer (pH 8.0) containing 20% glycerol, 0.1mM PMSF, 2mM EDTA, 2mM DTT, 200mM NaCl
Purity/Purification
> 95% by SDS-PAGE
Concentration
0.5 mg/ml (determined by Bradford assay) (lot specific)
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Molecular Weight
61.4kDa (535aa)
OMIM
X03674 mRNA
3D Structure
ModBase 3D Structure for P11413
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Antigen Species
Human
Tag Information
His-tag
Biological Activity
Specific activity is > 45 units/mg, obtained by measuring the increase of beta-NADPH in absorbance at 340 nm resulting from the reduction of beta-NADP. One unit oxidizes 1.0 umole D-glucose-6-phosphate to 6-phospho-D-gluconate per min in the presence of beta-NADP at pH 7.4 at 25C.

Product Categories/Family for G6PD active protein

Enzymes & Proteases
Applications Tested/Suitable for G6PD active protein
SDS-PAGE

SDS-Page of G6PD active protein

Baculovirus G6PD Active Protein – Cat# MBS204787

Product References and Citations for G6PD active protein

Huang Y., et al. (2008) Mol Genet Metab. 93 (1):44-53.; Zimny A., et al. (2003) Pol Arch Med Wewn. 110 (5):1327-33

Other Notes

Small volumes of G6PD active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for G6PD purchase

MBS204787 is an active protein targeting G6PD. Also known as G6PD, 1-515aa, Human, His tag, Baculovirus (Bioactivity Validated). Host: Baculovirus.

Additional Details

NCBI/Uniprot data below describe general gene information for G6PD. It may not necessarily be applicable to this product.

NCBI GI #
108773793
NCBI GeneID
2539
NCBI Accession #
NP_001035810.1
UniProt Primary Accession #
P11413
UniProt Secondary Accession #
Q16000; Q16765; Q8IU70; Q8IU88; Q8IUA6; Q96PQ2; D3DWX9
UniProt Related Accession #
P11413
GenBank Nucleotide #
NM_001042351.2
NCBI Official Full Name
glucose-6-phosphate 1-dehydrogenase isoform b
NCBI Official Synonym Full Names
glucose-6-phosphate dehydrogenase
NCBI Official Symbol
G6PD
NCBI Official Synonym Symbols
G6PD1
UniProt Protein Name
Glucose-6-phosphate 1-dehydrogenase
Protein Family
Glucose-6-phosphate 1-dehydrogenase
UniProt Gene Name
G6PD
UniProt Synonym Gene Names
G6PD
NCBI Protein Information
glucose-6-phosphate 1-dehydrogenase

NCBI Summary for G6PD

This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for G6PD

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis.

Research Articles on G6PD

1. Aggregated across all genotypes, we find that increasing levels of G6PD deficiency are associated with decreasing risk of cerebral malaria, but with increased risk of severe malarial anaemia.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with G6PD active protein

 Reference Product  PubMed Publications
 PGD active protein  >62 publications with G6PD and PGD
 GPI active protein  >62 publications with G6PD and GPI
 PGM1 active protein  >24 publications with G6PD and PGM1
 PKM active protein  >5 publications with G6PD and PKM
 H6PD active protein  >5 publications with G6PD and H6PD
 PGLS active protein  >3 publications with G6PD and PGLS
 PGAM1 active protein  >1 publications with G6PD and PGAM1
 GCK active protein  >1 publications with G6PD and GCK

Pathways associated with G6PD active protein

 Products by Pathway  Pathway Diagram
 ATM Signaling Network In Development And Disease Pathway antibodies  ATM Signaling Network In Development And Disease Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Central Carbon Metabolism In Cancer Pathway antibodies  Central Carbon Metabolism In Cancer Pathway Diagram
 Central Carbon Metabolism In Cancer Pathway antibodies  Central Carbon Metabolism In Cancer Pathway Diagram
 Cori Cycle Pathway antibodies  Cori Cycle Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Glutathione Metabolism Pathway antibodies  Glutathione Metabolism Pathway Diagram
 Glutathione Metabolism Pathway antibodies  Glutathione Metabolism Pathway Diagram

Diseases associated with G6PD active protein

 Disease Name  Pubmed Publications
 Glucosephosphate Dehydrogenase Deficiency Antibodies  >5375 publications with G6PD and Glucosephosphate Dehydrogenase Deficiency
 Anemia, Hemolytic Antibodies  >5037 publications with G6PD and Anemia, Hemolytic
 Hemolysis Antibodies  >1084 publications with G6PD and Hemolysis
 Malaria Antibodies  >789 publications with G6PD and Malaria
 Poisoning Antibodies  >698 publications with G6PD and Poisoning
 Favism Antibodies  >628 publications with G6PD and Favism
 Nervous System Diseases Antibodies  >415 publications with G6PD and Nervous System Diseases
 Liver Diseases Antibodies  >270 publications with G6PD and Liver Diseases
 Anemia, Hemolytic, Congenital Nonspherocytic Antibodies  >220 publications with G6PD and Anemia, Hemolytic, Congenital Nonspherocytic
 Kidney Diseases Antibodies  >143 publications with G6PD and Kidney Diseases

Organs/Tissues associated with G6PD active protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3911 publications with G6PD and Blood
 Liver Antibodies  >616 publications with G6PD and Liver
 Kidney Antibodies  >234 publications with G6PD and Kidney
 Muscle Antibodies  >155 publications with G6PD and Muscle
 Brain Antibodies  >153 publications with G6PD and Brain
 Bone Antibodies  >152 publications with G6PD and Bone
 Skin Antibodies  >123 publications with G6PD and Skin
 Bone Marrow Antibodies  >108 publications with G6PD and Bone Marrow
 Lung Antibodies  >102 publications with G6PD and Lung
 Vascular Antibodies  >94 publications with G6PD and Vascular
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