3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain

GP9 Recombinant Protein

Name: GP9 Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS204962
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS204962

GP9 is a small membrane glycoprotein found on the surface of human platelets. It forms a 1-to-1 noncovalent complex with glycoprotein Ib, a platelet surface membrane glycoprotein complex that functions as a receptor for von Willebrand factor. The complete… More details

$230 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GP9, Recombinant Protein

Full Product Name

GP9, 17-147aa, Human, His tag, E Coli (Denatured)

Product Gene Name

GP9 recombinant protein

Product Synonym Names

Platelet glycoprotein IX; CD42a; GPIX

Sequence

MGSSHHHHHH SSGLVPRGSH MGS TKDCPSP CTCRALETMG LWVDCRGHGL TALPALPART RHLLLANNSL QSVPPGAFDH LPQLQTLDVT QNPWHCDCSL TYLRLWLEDR TPEALLQVRC ASPSLAAHGP LGRLTGYQLG SCGWQLQASW VRPG

Host

E Coli

Form/Format

Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.4M UREA, 10% glycerol

Purity/Purification

> 90% by SDS-PAGE

Concentration

1 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 2°C to 8°C for 1 week.
For long term storage, aliquot and store at -20°C to -80°C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

16.8 kDa (154aa)

OMIM

X52997 mRNA

3D Structure

ModBase 3D Structure for P14770

Tag Information

His-tag

Domain

17-147aa

Product Categories/Family for GP9 recombinant protein

Immunology

Applications Tested/Suitable for GP9 recombinant protein

SDS-PAGE, Denatured

Application Notes for GP9 recombinant protein

This protein is denatured. Denatured protein is most likely not the best option for functional studies. Denatured protein is better suited for Western Blot (WB) or imaging assays. Applications are user determined.

Product References and Citations for GP9 recombinant protein

McEwan,P.A., et al. (2011) Blood 118 (19), 5292-5301; Sivaraman,B., et al. (2011) Biomaterials 32 (23), 5365-5370

Other Notes

Small volumes of GP9 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GP9 purchase

MBS204962 is a recombinant protein targeting GP9. Also known as GP9, 17-147aa, Human, His tag, E Coli (Denatured). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for GP9. It may not necessarily be applicable to this product.

NCBI GI #

4504077

NCBI GeneID

2815

NCBI Accession #

NP_000165

UniProt Primary Accession #

P14770

UniProt Secondary Accession #

Q14445; Q8N1D1; Q92525

UniProt Related Accession #

P14770

GenBank Nucleotide #

NP_000165.1

NCBI Official Full Name

platelet glycoprotein IX

NCBI Official Synonym Full Names

glycoprotein IX platelet

NCBI Official Symbol

GP9

NCBI Official Synonym Symbols

GPIX; CD42a

UniProt Protein Name

Platelet glycoprotein IX

UniProt Synonym Protein Names

Glycoprotein 9; CD_antigen: CD42a

Protein Family

Platelet glycoprotein

UniProt Gene Name

GP9

UniProt Synonym Gene Names

GP-IX; GPIX

NCBI Protein Information

platelet glycoprotein IX

NCBI Summary for GP9

This gene encodes a small membrane glycoprotein found on the surface of human platelets. It forms a 1-to-1 noncovalent complex with glycoprotein Ib, a platelet surface membrane glycoprotein complex that functions as a receptor for von Willebrand factor. The complete receptor complex includes noncovalent association of the alpha and beta subunits with the protein encoded by this gene and platelet glycoprotein V. Defects in this gene are a cause of Bernard-Soulier syndrome, also known as giant platelet disease. These patients have unusually large platelets and have a clinical bleeding tendency. [provided by RefSeq, Oct 2008]

UniProt Comments for GP9

The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib.

Research Articles on GP9

1. Data show that localization of the GP Ib-IX complex to the lipid domain is mediated by GP Ibbeta and GP IX transmembrane domains.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GP9 recombinant protein

Reference Product	PubMed Publications
GP1BB recombinant protein	>7 publications with GP9 and GP1BB
GP1BA recombinant protein	>6 publications with GP9 and GP1BA
VWF recombinant protein	>2 publications with GP9 and VWF
GP5 recombinant protein	>2 publications with GP9 and GP5

Pathways associated with GP9 recombinant protein

Products by Pathway	Pathway Diagram
ECM-receptor Interaction Pathway antibodies	ECM-receptor Interaction Pathway Diagram
ECM-receptor Interaction Pathway antibodies	ECM-receptor Interaction Pathway Diagram
Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies	Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
GP1b-IX-V Activation Signalling Pathway antibodies	GP1b-IX-V Activation Signalling Pathway Diagram
Hematopoietic Stem Cell Differentiation Pathway antibodies	Hematopoietic Stem Cell Differentiation Pathway Diagram
Hematopoietic Cell Lineage Pathway antibodies	Hematopoietic Cell Lineage Pathway Diagram
Hematopoietic Cell Lineage Pathway antibodies	Hematopoietic Cell Lineage Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram
Intrinsic Pathway Of Fibrin Clot Formation antibodies	Intrinsic Pathway Of Fibrin Clot Formation Diagram
Platelet Adhesion To Exposed Collagen Pathway antibodies	Platelet Adhesion To Exposed Collagen Pathway Diagram

Diseases associated with GP9 recombinant protein

Disease Name	Pubmed Publications
Bernard-Soulier Syndrome Antibodies	>10 publications with GP9 and Bernard-Soulier Syndrome
Thrombocytopenia Antibodies	>6 publications with GP9 and Thrombocytopenia
Hemorrhage Antibodies	>4 publications with GP9 and Hemorrhage
Cardiovascular Diseases Antibodies	>3 publications with GP9 and Cardiovascular Diseases
Heart Diseases Antibodies	>2 publications with GP9 and Heart Diseases
Immunologic Deficiency Syndromes Antibodies	>1 publications with GP9 and Immunologic Deficiency Syndromes
Fibrosis Antibodies	>1 publications with GP9 and Fibrosis
Pneumonia Antibodies	>1 publications with GP9 and Pneumonia
Weight Loss Antibodies	>1 publications with GP9 and Weight Loss
Inflammation Antibodies	>1 publications with GP9 and Inflammation

Organs/Tissues associated with GP9 recombinant protein

Organ/Tissue Name	Pubmed Publications
Heart Antibodies	>2 publications with GP9 and Heart
Lung Antibodies	>1 publications with GP9 and Lung