APOA5 Recombinant Protein

Name: APOA5 Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS205402
Price: 245 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS205402

APOA5 is an apolipoprotein that plays an important role in regulating the plasma triglyceride levels, a major risk factor for coronary artery disease. It is a component of high density lipoprotein and is highly similar to a rat protein that is upregulated in… More details

$245 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

APOA5, Recombinant Protein

Full Product Name

APOA5, 24-366aa, Human, His tag, E Coli (Denatured)

Product Gene Name

APOA5 recombinant protein

Product Synonym Names

Apolipoprotein A-V precursor; Apolipoprotein A-V; APOAV; RAP3

Sequence

MGSSHHHHHH SSGLVPRGSH MGSRKGFWDY FSQTSGDKGR VEQIHQQKMA REPATLKDSL EQDLNNMNKF LEKLRPLSGS EAPRLPQDPV GMRRQLQEEL EEVKARLQPY MAEAHELVGW NLEGLRQQLK PYTMDLMEQV ALRVQELQEQ LRVVGEDTKA QLLGGVDEAW ALLQGLQSRV VHHTGRFKEL FHPYAESLVS GIGRHVQELH RSVAPHAPAS PARLSRCVQV LSRKLTLKAK ALHARIQQNL DQLREELSRA FAGTGTEEGA GPDPQMLSEE VRQRLQAFRQ DTYLQIAAFT RAIDQETEEV QQQLAPPPPG HSAFAPEFQQ TDSGKVLSKL QARLDDLWED ITHSLHDQGH SHLGDP

Host

E Coli

Form/Format

Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing, 10% glycerol, 0.4M urea

Purity/Purification

> 85% by SDS-PAGE

Concentration

0.25 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

41.3kDa (366aa)

OMIM

AF202889 mRNA

3D Structure

ModBase 3D Structure for Q6Q788

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for APOA5 recombinant protein

Metabolism

Applications Tested/Suitable for APOA5 recombinant protein

SDS-PAGE

Application Notes for APOA5 recombinant protein

This protein is denatured. Denatured protein is most likely not the best option for functional studies. Denatured protein is better suited for Western Blot (WB) or imaging assays. Applications are user determined.

Product References and Citations for APOA5 recombinant protein

Weinberg R.B., et al. (2003) J. Biol. Chem. 278:34438-34444.

Other Notes

Small volumes of APOA5 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for APOA5 purchase

MBS205402 is a recombinant protein targeting APOA5. Also known as APOA5, 24-366aa, Human, His tag, E Coli (Denatured). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for APOA5. It may not necessarily be applicable to this product.

NCBI GI #

63079709

NCBI GeneID

116519

NCBI Accession #

NP_443200

UniProt Primary Accession #

Q6Q788

UniProt Secondary Accession #

Q3MIK6; Q6UWK9; Q9UBJ3; B0YIV9

UniProt Related Accession #

Q6Q788

GenBank Nucleotide #

NM_052968.4

NCBI Official Full Name

apolipoprotein A-V

NCBI Official Synonym Full Names

apolipoprotein A5

NCBI Official Symbol

APOA5

NCBI Official Synonym Symbols

RAP3; APOAV

UniProt Protein Name

Apolipoprotein A-V

UniProt Synonym Protein Names

Apolipoprotein A5; Regeneration-associated protein 3

Protein Family

Apolipoprotein

UniProt Gene Name

APOA5

UniProt Synonym Gene Names

RAP3; Apo-AV; ApoA-V

NCBI Protein Information

apolipoprotein A-V

NCBI Summary for APOA5

The protein encoded by this gene is an apolipoprotein that plays an important role in regulating the plasma triglyceride levels, a major risk factor for coronary artery disease. It is a component of high density lipoprotein and is highly similar to a rat protein that is upregulated in response to liver injury. Mutations in this gene have been associated with hypertriglyceridemia and hyperlipoproteinemia type 5. This gene is located proximal to the apolipoprotein gene cluster on chromosome 11q23. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Oct 2009]

UniProt Comments for APOA5

Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages.

Research Articles on APOA5

1. that apos involved in TG metabolism such as apoC2, C3, E, and A4 (micromolar concentration), and apoB48 and apoA5 (single-digit nanomolar concentration) can be quantified from a single digestion mixture.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with APOA5 recombinant protein

Reference Product	PubMed Publications
APOC3 recombinant protein	>90 publications with APOA5 and APOC3
APOE recombinant protein	>89 publications with APOA5 and APOE
APOA1 recombinant protein	>66 publications with APOA5 and APOA1
APOB recombinant protein	>60 publications with APOA5 and APOB
APOA4 recombinant protein	>40 publications with APOA5 and APOA4
APOA2 recombinant protein	>5 publications with APOA5 and APOA2
PPARA recombinant protein	>4 publications with APOA5 and PPARA
CREB3L3 recombinant protein	>2 publications with APOA5 and CREB3L3

Pathways associated with APOA5 recombinant protein

Products by Pathway	Pathway Diagram
Chylomicron-mediated Lipid Transport Pathway antibodies	Chylomicron-mediated Lipid Transport Pathway Diagram
Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies	Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
Lipid Digestion, Mobilization, And Transport Pathway antibodies	Lipid Digestion, Mobilization, And Transport Pathway Diagram
Lipoprotein Metabolism Pathway antibodies	Lipoprotein Metabolism Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Lipids And Lipoproteins Pathway antibodies	Metabolism Of Lipids And Lipoproteins Pathway Diagram
PPAR Alpha Pathway antibodies	PPAR Alpha Pathway Diagram
PPAR Signaling Pathway antibodies	PPAR Signaling Pathway Diagram
PPAR Signaling Pathway antibodies	PPAR Signaling Pathway Diagram
PPARA Activates Gene Expression Pathway antibodies	PPARA Activates Gene Expression Pathway Diagram

Diseases associated with APOA5 recombinant protein

Disease Name	Pubmed Publications
Dyslipidemias Antibodies	>226 publications with APOA5 and Dyslipidemias
Hypertriglyceridemia Antibodies	>199 publications with APOA5 and Hypertriglyceridemia
Cardiovascular Diseases Antibodies	>192 publications with APOA5 and Cardiovascular Diseases
Hyperlipidemias Antibodies	>185 publications with APOA5 and Hyperlipidemias
Heart Diseases Antibodies	>112 publications with APOA5 and Heart Diseases
Atherosclerosis Antibodies	>108 publications with APOA5 and Atherosclerosis
Coronary Artery Disease Antibodies	>79 publications with APOA5 and Coronary Artery Disease
Insulin Resistance Antibodies	>71 publications with APOA5 and Insulin Resistance
Hypertension Antibodies	>29 publications with APOA5 and Hypertension
Liver Diseases Antibodies	>25 publications with APOA5 and Liver Diseases

Organs/Tissues associated with APOA5 recombinant protein

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>74 publications with APOA5 and Liver
Lung Antibodies	>2 publications with APOA5 and Lung