uMPS Recombinant Protein

Name: uMPS Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS205410
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS205410

uridine 5'-monophosphate synthase, also known as uMPS, is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. unlike prokaryotes, uMPS in eukaryotes combines the orotate phosphoribosyltransferase and the… More details

$230 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

uMPS, Recombinant Protein

Full Product Name

uMPS, 1-480aa, Human, His tag, E Coli (Denatured)

Product Gene Name

uMPS recombinant protein

Product Synonym Names

uridine 5'-monophosphate synthase; OPRT

Sequence

MGSSHHHHHH SSGLVPRGSH MAVARAALGP LVTGLYDVQA FKFGDFVLKS GLSSPIYIDL RGIVSRPRLL SQVADILFQT AQNAGISFDT VCGVPYTALP LATVICSTNQ IPMLIRRKET KDYGTKRLVE GTINPGETCL IIEDVVTSGS SVLETVEVLQ KEGLKVTDAI VLLDREQGGK DKLQAHGIRL HSVCTLSKML EILEQQKKVD AETVGRVKRF IQENVFVAAN HNGSPLSIKE APKELSFGAR AELPRIHPVA SKLLRLMQKK ETNLCLSADV SLARELLQLA DALGPSICML KTHVDILNDF TLDVMKELIT LAKCHEFLIF EDRKFADIGN TVKKQYEGGI FKIASWADLV NAHVVPGSGV VKGLQEVGLP LHRGCLLIAE MSSTGSLATG DYTRAAVRMA EEHSEFVVGF ISGSRVSMKP EFLHLTPGVQ LEAGGDNLGQ QYNSPQEVIG KRGSDIIIVG RGIISAADRL EAAEMYRKAA WEAYLSRLGV

Host

E Coli

Form/Format

Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 2M urea, 20% glycerol

Purity/Purification

> 90% by SDS-PAGE

Concentration

1 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

54.3 kDa (500aa)

OMIM

J03626 mRNA

3D Structure

ModBase 3D Structure for P11172

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for uMPS recombinant protein

Metabolism

Applications Tested/Suitable for uMPS recombinant protein

SDS-PAGE

Application Notes for uMPS recombinant protein

This protein is denatured. Denatured protein is most likely not the best option for functional studies. Denatured protein is better suited for Western Blot (WB) or imaging assays. Applications are user determined.

Product References and Citations for uMPS recombinant protein

Suchi M., et al. (1997) Genet. 60:525-539.; Yablonski M J., et al. (1996) J Biol Chem. 271:10704-10708.;

Other Notes

Small volumes of uMPS recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for uMPS purchase

MBS205410 is a recombinant protein targeting uMPS. Also known as uMPS, 1-480aa, Human, His tag, E Coli (Denatured). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for uMPS. It may not necessarily be applicable to this product.

NCBI GI #

4507835

NCBI GeneID

7372

NCBI Accession #

NP_000364

UniProt Primary Accession #

P11172

UniProt Secondary Accession #

O00758; O00759; O00760; Q16862; Q9H3Q2; Q9UG49; B5LY68; B5LY72

UniProt Related Accession #

P11172

GenBank Nucleotide #

NM_000373.3

NCBI Official Full Name

uridine 5'-monophosphate synthase

NCBI Official Synonym Full Names

uridine monophosphate synthetase

NCBI Official Symbol

UMPS

NCBI Official Synonym Symbols

OPRT

UniProt Protein Name

Uridine 5'-monophosphate synthase

UniProt Synonym Protein Names

Orotate phosphoribosyltransferase (EC:2.4.2.10); OPRT; OPRTaseOrotidine 5'-phosphate decarboxylase (EC:4.1.1.23); ODCAlternative name(s):OMPdecase

Protein Family

Uridine 5'-monophosphate synthase

UniProt Gene Name

UMPS

UniProt Synonym Gene Names

UMP synthase; OPRT; OPRTase; ODC

NCBI Protein Information

uridine 5'-monophosphate synthase

NCBI Summary for uMPS

This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

Research Articles on uMPS

1. Partial UMPS-deficiency should be included in the differential diagnosis of mild orotic aciduria.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with uMPS recombinant protein

Reference Product	PubMed Publications
DPYD recombinant protein	>5 publications with uMPS and DPYD
DHODH recombinant protein	>2 publications with uMPS and DHODH
CAD recombinant protein	>2 publications with uMPS and CAD
GMPS recombinant protein	>1 publications with uMPS and GMPS
GART recombinant protein	>1 publications with uMPS and GART

Pathways associated with uMPS recombinant protein

Products by Pathway	Pathway Diagram
Drug Metabolism - Other Enzymes Pathway antibodies	Drug Metabolism - Other Enzymes Pathway Diagram
Drug Metabolism - Other Enzymes Pathway antibodies	Drug Metabolism - Other Enzymes Pathway Diagram
Fluoropyrimidine Activity Pathway antibodies	Fluoropyrimidine Activity Pathway Diagram
Metabolic Pathways antibodies	Metabolic Pathways Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Nucleotides Pathway antibodies	Metabolism Of Nucleotides Pathway Diagram
Pyrimidine Biosynthesis Pathway antibodies	Pyrimidine Biosynthesis Pathway Diagram
Pyrimidine Metabolism Pathway antibodies	Pyrimidine Metabolism Pathway Diagram
Pyrimidine Metabolism Pathway antibodies	Pyrimidine Metabolism Pathway Diagram
Pyrimidine Metabolism Pathway antibodies	Pyrimidine Metabolism Pathway Diagram

Diseases associated with uMPS recombinant protein

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>7 publications with uMPS and Nervous System Diseases
Colorectal Neoplasms Antibodies	>6 publications with uMPS and Colorectal Neoplasms
Anemia Antibodies	>3 publications with uMPS and Anemia
Neoplasms, Experimental Antibodies	>3 publications with uMPS and Neoplasms, Experimental
Cardiovascular Diseases Antibodies	>2 publications with uMPS and Cardiovascular Diseases
Heart Diseases Antibodies	>1 publications with uMPS and Heart Diseases
Fatty Liver Antibodies	>1 publications with uMPS and Fatty Liver
Inflammation Antibodies	>1 publications with uMPS and Inflammation
Edema Antibodies	>1 publications with uMPS and Edema
Oroticaciduria 1 Antibodies	>1 publications with uMPS and Oroticaciduria 1

Organs/Tissues associated with uMPS recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>23 publications with uMPS and Blood
Vascular Antibodies	>13 publications with uMPS and Vascular
Muscle Antibodies	>8 publications with uMPS and Muscle
Thyroid Antibodies	>6 publications with uMPS and Thyroid
Liver Antibodies	>5 publications with uMPS and Liver
Heart Antibodies	>5 publications with uMPS and Heart
Embryonic Tissue Antibodies	>3 publications with uMPS and Embryonic Tissue
Bone Antibodies	>3 publications with uMPS and Bone
Kidney Antibodies	>3 publications with uMPS and Kidney
Skin Antibodies	>2 publications with uMPS and Skin