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DDX39A Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS205565

DDX39A is a member of the DEAD box protein family. This protein is characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD) and are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary… More details

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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
DDX39A, Recombinant Protein
Full Product Name
DDX39A, 1-249aa, Human, His tag, E Coli (Denatured)
Product Gene Name
DDX39A recombinant protein
Product Synonym Names
ATP-dependent RNA helicase DDX39A; DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A; BAT1; BAT1L; DDX39; DDXL; uRH49
Sequence
MGSSHHHHHH SSGLVPRGSH MGSEFMAEQD VENDLLDYDE EEEPQAPQES TPAPPKKDIK GSYVSIHSSG FRDFLLKPEL LRAIVDCGFE HPSEVQHECI PQAILGMDVL CQAKSGMGKT AVFVLATLQQ IEPVNGQVTV LVMCHTRELA FQISKEYERF SKYMPSVKVS VFFGGLSIKK DEEVLKKNCP HVVVGTPGRI LALVRNRSFS LKNVKHFVLD ECDKMLEQLD MRRDVQEIFR LTPHEKQCMM FSATLSKDIR PVCRKFMQDP MEVF
Host
E Coli
Form/Format
Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 10% glycerol, 0.4M urea
Purity/Purification
> 80% by SDS-PAGE
Concentration
1.0 mg/ml (determined by Bradford assay) (lot specific)
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Molecular Weight
31.0 kDa (274 aa)
3D Structure
ModBase 3D Structure for O00148
Antigen Species
Human
Tag Information
His-tag

Product Categories/Family for DDX39A recombinant protein

Epigenomics (Transcription & Translation)
Applications Tested/Suitable for DDX39A recombinant protein
SDS-PAGE
Application Notes for DDX39A recombinant protein
This protein is denatured. Denatured protein is most likely not the best option for functional studies. Denatured protein is better suited for Western Blot (WB) or imaging assays. Applications are user determined.

SDS-Page of DDX39A recombinant protein

DDX39A Recombinant Protein – Cat# MBS205565

Product References and Citations for DDX39A recombinant protein

Pryor A., Tung L. et al. (2004). Nucleic Acids Res. 32:1857-1865

Other Notes

Small volumes of DDX39A recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DDX39A purchase

MBS205565 is a recombinant protein targeting DDX39A. Also known as DDX39A, 1-249aa, Human, His tag, E Coli (Denatured). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for DDX39A. It may not necessarily be applicable to this product.

NCBI GI #
21040371
NCBI GeneID
10212
NCBI Accession #
NP_005795
UniProt Primary Accession #
O00148
UniProt Secondary Accession #
Q8N5M0; Q9BVP6; Q9H5W0; B1Q2N1
UniProt Related Accession #
O00148
GenBank Nucleotide #
NM_005804.3
NCBI Official Full Name
ATP-dependent RNA helicase DDX39A
NCBI Official Synonym Full Names
DExD-box helicase 39A
NCBI Official Symbol
DDX39A
NCBI Official Synonym Symbols
BAT1; DDXL; BAT1L; DDX39; URH49
UniProt Protein Name
ATP-dependent RNA helicase DDX39A
UniProt Synonym Protein Names
DEAD box protein 39; Nuclear RNA helicase URH49
Protein Family
ATP-dependent RNA helicase
UniProt Gene Name
DDX39A
UniProt Synonym Gene Names
DDX39
NCBI Protein Information
ATP-dependent RNA helicase DDX39A

NCBI Summary for DDX39A

This gene encodes a member of the DEAD box protein family. These proteins are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD) and are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene is thought to play a role in the prognosis of patients with gastrointestinal stromal tumors. A pseudogene of this gene is present on chromosome 13. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]
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UniProt Comments for DDX39A

Isoform 1: Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus.

Research Articles on DDX39A

1. DDX39B and its paralog DDX39A regulate androgen receptor splice variant AR-V7 generation

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with DDX39A recombinant protein

 Reference Product  PubMed Publications
 ALYREF recombinant protein  >3 publications with DDX39A and ALYREF
 SARNP recombinant protein  >2 publications with DDX39A and SARNP

Pathways associated with DDX39A recombinant protein

 Products by Pathway  Pathway Diagram
 Cleavage Of Growing Transcript In The Termination Region Pathway antibodies  Cleavage Of Growing Transcript In The Termination Region Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Processing Of Capped Intron-Containing Pre-mRNA Pathway antibodies  Processing Of Capped Intron-Containing Pre-mRNA Pathway Diagram
 RNA Polymerase II Transcription Pathway antibodies  RNA Polymerase II Transcription Pathway Diagram
 RNA Polymerase II Transcription Termination Pathway antibodies  RNA Polymerase II Transcription Termination Pathway Diagram
 Transport Of Mature Transcript To Cytoplasm Pathway antibodies  Transport Of Mature Transcript To Cytoplasm Pathway Diagram
 Transport Of Mature MRNA Derived From An Intron-Containing Transcript Pathway antibodies  Transport Of Mature MRNA Derived From An Intron-Containing Transcript Pathway Diagram
 MRNA 3'-end Processing Pathway antibodies  MRNA 3'-end Processing Pathway Diagram

Diseases associated with DDX39A recombinant protein

 Disease Name  Pubmed Publications
 Lung Neoplasms Antibodies  >3 publications with DDX39A and Lung Neoplasms
 Nervous System Diseases Antibodies  >2 publications with DDX39A and Nervous System Diseases
 Abnormalities, Multiple Antibodies  >1 publications with DDX39A and Abnormalities, Multiple
 Kidney Diseases Antibodies  >1 publications with DDX39A and Kidney Diseases
 Adenocarcinoma Antibodies  >1 publications with DDX39A and Adenocarcinoma
 Anemia Antibodies  >1 publications with DDX39A and Anemia
 Inflammation Antibodies  >1 publications with DDX39A and Inflammation
 Necrosis Antibodies  >1 publications with DDX39A and Necrosis

Organs/Tissues associated with DDX39A recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >5 publications with DDX39A and Lung
 Bladder Antibodies  >3 publications with DDX39A and Bladder
 Brain Antibodies  >3 publications with DDX39A and Brain
 Kidney Antibodies  >2 publications with DDX39A and Kidney
 Blood Antibodies  >2 publications with DDX39A and Blood
 Heart Antibodies  >1 publications with DDX39A and Heart
 Intestine Antibodies  >1 publications with DDX39A and Intestine
 Prostate Antibodies  >1 publications with DDX39A and Prostate
 Testis Antibodies  >1 publications with DDX39A and Testis
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