TNFSF8 Recombinant Protein

Name: TNFSF8 Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS205766
Price: 375 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS205766

TNFSF8 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

TNFSF8, Recombinant Protein

Full Product Name

TNFSF8, 63- 234aa, Human, His tag, E Coli (Denatured)

Product Gene Name

TNFSF8 recombinant protein

Product Synonym Names

tumor necrosis factor ligand superfamily member 8; CD153; CD30L; CD30LG

Sequence

MGSSHHHHHH SSGLVPRGSH MGSQRTDSIP NSPDNVPLKG GNCSEDLLCI LKRAPFKKSW AYLQVAKHLN KTKLSWNKDG ILHGVRYQDG NLVIQFPGLY FIICQLQFLV QCPNNSVDLK LELLINKHIK KQALVTVCES GMQTKHVYQN LSQFLLDYLQ VNTTISVNVD TFQYIDTSTF PLENVLSIFL YSNSD

Host

E Coli

Form/Format

Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 10% glycerol, 0.4M urea

Purity/Purification

> 80% by SDS-PAGE

Concentration

0.5 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

22.0 kDa (195aa)

OMIM

L09753 mRNA

3D Structure

ModBase 3D Structure for P32971

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for TNFSF8 recombinant protein

Immunology

Applications Tested/Suitable for TNFSF8 recombinant protein

SDS-PAGE

Product References and Citations for TNFSF8 recombinant protein

Smith C.A., et al (1993). Armitage R.J. Cell 73:1349-1360; Croager E.J., et al (1997). Biochim. Biophys. Acta 1353:231-235;

Other Notes

Small volumes of TNFSF8 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TNFSF8 purchase

MBS205766 is a recombinant protein targeting TNFSF8. Also known as TNFSF8, 63- 234aa, Human, His tag, E Coli (Denatured). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for TNFSF8. It may not necessarily be applicable to this product.

NCBI GI #

4507607

NCBI GeneID

944

NCBI Accession #

NP_001235

UniProt Primary Accession #

P32971

UniProt Secondary Accession #

O43404

UniProt Related Accession #

P32971

GenBank Nucleotide #

NM_001244.3

NCBI Official Full Name

tumor necrosis factor ligand superfamily member 8 isoform 1

NCBI Official Synonym Full Names

TNF superfamily member 8

NCBI Official Symbol

TNFSF8

NCBI Official Synonym Symbols

CD153; CD30L; CD30LG; TNLG3A

UniProt Protein Name

Tumor necrosis factor ligand superfamily member 8

UniProt Synonym Protein Names

CD30 ligand; CD30-L; CD_antigen: CD153

Protein Family

Tumor necrosis factor ligand superfamily

UniProt Gene Name

TNFSF8

UniProt Synonym Gene Names

CD30L; CD30LG; CD30-L

NCBI Protein Information

tumor necrosis factor ligand superfamily member 8

NCBI Summary for TNFSF8

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

UniProt Comments for TNFSF8

Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells.

Research Articles on TNFSF8

1. Data suggest that Brentuximab Vedotin (SGN-35) damaged CD30 ligand (CD30L)-immune cells through CD30 extracellular vesicles (EVs).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TNFSF8 recombinant protein

Reference Product	PubMed Publications
TNFSF4 recombinant protein	>13 publications with TNFSF8 and TNFSF4
CD70 recombinant protein	>13 publications with TNFSF8 and CD70
TNFSF15 recombinant protein	>7 publications with TNFSF8 and TNFSF15
TNFRSF4 recombinant protein	>6 publications with TNFSF8 and TNFRSF4
TNFSF9 recombinant protein	>6 publications with TNFSF8 and TNFSF9
TNFRSF8 recombinant protein	>3 publications with TNFSF8 and TNFRSF8
CD40LG recombinant protein	>1 publications with TNFSF8 and CD40LG

Pathways associated with TNFSF8 recombinant protein

Products by Pathway	Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
TNFR2 Non-canonical NF-kB Pathway antibodies	TNFR2 Non-canonical NF-kB Pathway Diagram
TNFs Bind Their Physiological Receptors Pathway antibodies	TNFs Bind Their Physiological Receptors Pathway Diagram

Diseases associated with TNFSF8 recombinant protein

Disease Name	Pubmed Publications
Necrosis Antibodies	>64 publications with TNFSF8 and Necrosis
Immune System Diseases Antibodies	>57 publications with TNFSF8 and Immune System Diseases
Death Antibodies	>20 publications with TNFSF8 and Death
Inflammation Antibodies	>11 publications with TNFSF8 and Inflammation
Lung Diseases Antibodies	>6 publications with TNFSF8 and Lung Diseases
Skin Neoplasms Antibodies	>6 publications with TNFSF8 and Skin Neoplasms
Cardiovascular Diseases Antibodies	>5 publications with TNFSF8 and Cardiovascular Diseases
Lung Neoplasms Antibodies	>3 publications with TNFSF8 and Lung Neoplasms
Heart Diseases Antibodies	>3 publications with TNFSF8 and Heart Diseases
Nervous System Diseases Antibodies	>2 publications with TNFSF8 and Nervous System Diseases

Organs/Tissues associated with TNFSF8 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>78 publications with TNFSF8 and Blood
Lymph Node Antibodies	>12 publications with TNFSF8 and Lymph Node
Spleen Antibodies	>11 publications with TNFSF8 and Spleen
Lung Antibodies	>7 publications with TNFSF8 and Lung
Thymus Antibodies	>6 publications with TNFSF8 and Thymus
Heart Antibodies	>5 publications with TNFSF8 and Heart
Bone Marrow Antibodies	>5 publications with TNFSF8 and Bone Marrow
Placenta Antibodies	>2 publications with TNFSF8 and Placenta
Kidney Antibodies	>2 publications with TNFSF8 and Kidney
Pharynx Antibodies	>2 publications with TNFSF8 and Pharynx