Cyclin Dependent Kinase 1 (CDK1) Antibody – Rabbit Polyclonal

CDK1: a protein kinase of the CDK family. Catalytic subunit of the conserved protein complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions. Mitotic cyclins stably associate with this protein and function as regulatory subunits. Its activity is controlled by cyclin availability and phosphorylation through the cell cycle. Activated in many cancers including colon, liver and breast. The T isoform, which lacks a regulatory region, is expressed in breast cancer. Inhibition in cancer cells may drive cells into apoptosis. May also drive cell migration. Inhibitors: BMS-265246, BMS-265246-01. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: CDK family; CDK/CDK1 subfamily; CDK1 subfamily; CMGC group; Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)

Chromosomal Location of Human Ortholog: 20p11

Cellular Component: centrosome; cytoplasm; membrane; midbody; nuclear chromosome, telomeric region; nucleus; spindle microtubule

Molecular Function: chromatin binding; cyclin binding; cyclin-dependent protein kinase activity; histone kinase activity; Hsp70 protein binding; kinase activity; protein binding; protein kinase activity; protein serine/threonine kinase activity; RNA polymerase subunit kinase activity

Biological Process: cell aging; cell proliferation; chromosome condensation; epithelial cell differentiation; mitotic cell cycle; mitotic cell cycle G2/M transition DNA damage checkpoint; negative regulation of apoptosis; organ regeneration; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of cardiac muscle cell proliferation; positive regulation of DNA replication; positive regulation of mitotic cell cycle; positive regulation of protein import into nucleus, translocation; protein amino acid phosphorylation; protein complex assembly; response to activity; response to amine stimulus; response to axon injury; response to cadmium ion; response to copper ion; response to drug; response to ethanol; response to hydrogen peroxide; response to organic cyclic substance; response to organic nitrogen; response to toxin; ventricular cardiac muscle cell development