• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

SEPW1 Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS206061

SEPW1 is a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the uGA codon that normally signals translation termination. The 3' uTR of selenoprotein genes have a common stem-loop structure, the… More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Product Name
SEPW1, Recombinant Protein
Full Product Name
SEPW1, 1-87aa, Human, His tag, E Coli
Product Gene Name
SEPW1 recombinant protein
Product Synonym Names
Selenoprotein W; selW
Sequence
MGSSHHHHHH SSGLVPRGSH MGSMALAVRV VYCGACGYKS KYLQLKKKLE DEFPGRLDIC GEGTPQATGF FEVMVAGKLI HSKKKGDGYV DTESKFLKLV AAIKAALAQG
Host
E Coli
Form/Format
Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.15M NaCl, 20% glycerol, 1mM DTT
Purity/Purification
> 95% by SDS-PAGE
Concentration
0.25 mg/ml (determined by Bradford assay) (lot specific)
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Molecular Weight
11.8kDa (110aa) confirmed by MALDI-TOF
OMIM
U67171 mRNA
3D Structure
ModBase 3D Structure for P63302
Antigen Species
Human
Tag Information
His-tag
Applications Tested/Suitable for SEPW1 recombinant protein
SDS-PAGE

SDS-Page of SEPW1 recombinant protein

SEPW1 Recombinant Protein – Cat# MBS206061

Product References and Citations for SEPW1 recombinant protein

Hawkes,W.C., et al. (2012) J. Biol. Chem. 287 (33), 27371-27379; Hawkes,W.C., et al. (2012) J. Cell. Biochem. 113 (1), 61-69

Other Notes

Small volumes of SEPW1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SEPW1 purchase

MBS206061 is a recombinant protein targeting SEPW1. Also known as SEPW1, 1-87aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for SEPW1. It may not necessarily be applicable to this product.

NCBI GI #
4506887
NCBI GeneID
6415
NCBI Accession #
NP_003000
UniProt Primary Accession #
P63302
UniProt Secondary Accession #
O15532; O19096; Q86TI9; Q96KM5; A8MRR7
UniProt Related Accession #
P63302
GenBank Nucleotide #
NM_003009.3
NCBI Official Full Name
selenoprotein W
NCBI Official Synonym Full Names
selenoprotein W
NCBI Official Symbol
SELENOW
NCBI Official Synonym Symbols
selW; SEPW1
UniProt Protein Name
Selenoprotein W
Protein Family
Selenoprotein
UniProt Gene Name
SELENOW
UniProt Synonym Gene Names
SelW
NCBI Protein Information
selenoprotein W

NCBI Summary for SEPW1

This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is highly expressed in skeletal muscle, heart and brain. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Studies in mouse show that this selenoprotein is involved in muscle growth and differentiation, and in the protection of neurons from oxidative stress during neuronal development. A retroprocessed pseudogene of this locus has been identified on chromosome 1. [provided by RefSeq, Aug 2017]
Show more

UniProt Comments for SEPW1

Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency ().

Research Articles on SEPW1

1. SelW may have a regulatory function in redox cell signaling by interacting with 14-3-3 protein.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SEPW1 recombinant protein

 Reference Product  PubMed Publications
 SEPHS2 recombinant protein  >1 publications with SEPW1 and SEPHS2
 SELK recombinant protein  >1 publications with SEPW1 and SELK
 SEP15 recombinant protein  >1 publications with SEPW1 and SEP15
 SEPP1 recombinant protein  >1 publications with SEPW1 and SEPP1
 C11orf31 recombinant protein  >1 publications with SEPW1 and C11orf31
 VIMP recombinant protein  >1 publications with SEPW1 and VIMP
 SELT recombinant protein  >1 publications with SEPW1 and SELT
 SEPW1 recombinant protein  >1 publications with SEPW1 and SEPW1

Pathways associated with SEPW1 recombinant protein

 Products by Pathway  Pathway Diagram
 Selenium Metabolism And Selenoproteins Pathway antibodies  Selenium Metabolism And Selenoproteins Pathway Diagram
 Selenium Micronutrient Network Pathway antibodies  Selenium Micronutrient Network Pathway Diagram
 Selenium Micronutrient Network Pathway antibodies  Selenium Micronutrient Network Pathway Diagram
 Selenium Micronutrient Network Pathway antibodies  Selenium Micronutrient Network Pathway Diagram

Diseases associated with SEPW1 recombinant protein

 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >4 publications with SEPW1 and Brain Diseases
 Congenital Abnormalities Antibodies  >1 publications with SEPW1 and Congenital Abnormalities
 Abnormalities, Multiple Antibodies  >1 publications with SEPW1 and Abnormalities, Multiple
 Liver Diseases Antibodies  >1 publications with SEPW1 and Liver Diseases
 Heart Diseases Antibodies  >1 publications with SEPW1 and Heart Diseases
 Kidney Diseases Antibodies  >1 publications with SEPW1 and Kidney Diseases

Organs/Tissues associated with SEPW1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >6 publications with SEPW1 and Eye
 Liver Antibodies  >2 publications with SEPW1 and Liver
 Blood Antibodies  >2 publications with SEPW1 and Blood
 Muscle Antibodies  >2 publications with SEPW1 and Muscle
 Nerve Antibodies  >1 publications with SEPW1 and Nerve
 Kidney Antibodies  >1 publications with SEPW1 and Kidney
 Testis Antibodies  >1 publications with SEPW1 and Testis
 Heart Antibodies  >1 publications with SEPW1 and Heart
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000