Baculovirus AGA Recombinant Protein – Cat# MBS206447

AGA Baculovirus Recombinant Protein

Name: AGA Recombinant Protein; Baculovirus; MyBioSource
Brand: MyBioSource
SKU: MBS206447
Price: 365 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS206447

AGA, as known as N (4)- (beta-N-acetylglucosaminyl)-L-asparaginase isoform 1, belongs to the N-terminal nucleophile (Ntn) hydrolase superfamily. This protein consists of different S100 proteins and then plays various roles in regulation of protein… More details

$365 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

AGA, Recombinant Protein

Full Product Name

AGA, 24-346aa, Human, His-tag, Baculovirus

Product Gene Name

AGA recombinant protein

Product Synonym Names

N (4)- (beta-N-acetylglucosaminyl)-L-asparaginase isoform 1; AGA; AGU; ASRG; GA

Sequence

ADPSSPLPLV VNTWPFKNAT EAAWRALASG GSALDAVESG CAMCEREQCD GSVGFGGSPD ELGETTLDAM IMDGTTMDVG AVGDLRRIKN AIGVARKVLE HTTHTLLVGE SATTFAQSMG FINEDLSTTA SQALHSDWLA RNCQPNYWRN VIPDPSKYCG PYKPPGILKQ DIPIHKETED DRGHDTIGMV VIHKTGHIAA GTSTNGIKFK IHGRVGDSPI PGAGAYADDT AGAAAATGNG DILMRFLPSY QAVEYMRRGE DPTIACQKVI SRIQKHFPEF FGAVICANVT GSYGAACNKL STFTQFSFMV YNSEKNQPTE EKVDCIHHHH HH

Host

Baculovirus

Form/Format

Liquid. In phosphate buffered saline (pH 7.4) containing 10% glycerol.

Purity/Purification

> 90% by SDS-PAGE

Concentration

0.25mg/ml (determined by Absorbance at 280nm) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

35.7kDa (332aa) 18-57kDa (SDS-PAGE under reducing conditions.)

OMIM

X55762 mRNA

3D Structure

ModBase 3D Structure for P20933

Antigen Species

Human

Tag Information

His-tag

Endotoxin Level

< 1.0 EU per 1 microgram of protein (determined by LAL method)

Product Categories/Family for AGA recombinant protein

Cell Cycle

Applications Tested/Suitable for AGA recombinant protein

SDS-PAGE

Product References and Citations for AGA recombinant protein

Saarela J., et al. (2004) Biochem. J. 378:363-371.; Ikonen E., et al. (1992) Hum. Mutat. 1:361-365.

Other Notes

Small volumes of AGA recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AGA purchase

MBS206447 is a recombinant protein targeting AGA. Also known as AGA, 24-346aa, Human, His-tag, Baculovirus. Host: Baculovirus.

Additional Details

NCBI/Uniprot data below describe general gene information for AGA. It may not necessarily be applicable to this product.

NCBI GI #

285002251

NCBI GeneID

175

NCBI Accession #

NP_000018

UniProt Primary Accession #

P20933

UniProt Secondary Accession #

Q4W5Q2; Q6FHN6; Q9UCK6; Q9UCK7; Q9UCK8; B2R7H2; D3DP47

UniProt Related Accession #

P20933

GenBank Nucleotide #

NM_000027.3

NCBI Official Full Name

N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase isoform 1 preproprotein

NCBI Official Synonym Full Names

aspartylglucosaminidase

NCBI Official Symbol

AGA

NCBI Official Synonym Symbols

GA; AGU; ASRG

UniProt Protein Name

N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase

UniProt Synonym Protein Names

Aspartylglucosaminidase; Glycosylasparaginase; N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase

Protein Family

N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase

UniProt Gene Name

AGA

NCBI Protein Information

N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase

NCBI Summary for AGA

This gene encodes a member of the N-terminal nucleophile (Ntn) hydrolase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta chains that comprise the mature enzyme. This enzyme is involved in the catabolism of N-linked oligosaccharides of glycoproteins. It cleaves asparagine from N-acetylglucosamines as one of the final steps in the lysosomal breakdown of glycoproteins. Mutations in this gene are associated with the lysosomal storage disease aspartylglycosaminuria that results in progressive neurodegeneration. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is subject to proteolytic processing. [provided by RefSeq, Nov 2015]

UniProt Comments for AGA

Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins.

Research Articles on AGA

1. We show that gene-silenced cells show specifically reduced AGA activity and store globotriaosylceramide. In gene-silenced cells, release of the neurotransmitter acetylcholine is significantly reduced, demonstrating that this model may be used to study specific neuronal functions such as neurotransmitter release in Fabry disease

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with AGA recombinant protein

Reference Product	PubMed Publications
GAA recombinant protein	>34 publications with AGA and GAA

Pathways associated with AGA recombinant protein

Products by Pathway	Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram
L-asparagine Degradation III (mammalian) Pathway antibodies	L-asparagine Degradation III (mammalian) Pathway Diagram
Lysosome Pathway antibodies	Lysosome Pathway Diagram
Lysosome Pathway antibodies	Lysosome Pathway Diagram
Neutrophil Degranulation Pathway antibodies	Neutrophil Degranulation Pathway Diagram
Other Glycan Degradation Pathway antibodies	Other Glycan Degradation Pathway Diagram
Other Glycan Degradation Pathway antibodies	Other Glycan Degradation Pathway Diagram
Asparagine Degradation Pathway antibodies	Asparagine Degradation Pathway Diagram

Diseases associated with AGA recombinant protein

Disease Name	Pubmed Publications
Brain Diseases Antibodies	>566 publications with AGA and Brain Diseases
Fetal Growth Retardation Antibodies	>558 publications with AGA and Fetal Growth Retardation
Pain Antibodies	>542 publications with AGA and Pain
Diabetes Mellitus Antibodies	>394 publications with AGA and Diabetes Mellitus
Inflammation Antibodies	>329 publications with AGA and Inflammation
Fever Antibodies	>307 publications with AGA and Fever
Anemia Antibodies	>234 publications with AGA and Anemia
Kidney Diseases Antibodies	>198 publications with AGA and Kidney Diseases
Weight Gain Antibodies	>196 publications with AGA and Weight Gain
Heart Defects, Congenital Antibodies	>192 publications with AGA and Heart Defects, Congenital

Organs/Tissues associated with AGA recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>2631 publications with AGA and Blood
Brain Antibodies	>722 publications with AGA and Brain
Heart Antibodies	>707 publications with AGA and Heart
Vascular Antibodies	>618 publications with AGA and Vascular
Bone Antibodies	>470 publications with AGA and Bone
Liver Antibodies	>422 publications with AGA and Liver
Skin Antibodies	>324 publications with AGA and Skin
Muscle Antibodies	>320 publications with AGA and Muscle
Intestine Antibodies	>308 publications with AGA and Intestine
Lung Antibodies	>303 publications with AGA and Lung