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UQCRB Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9603407

Function: This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This component is involved in redox-linked proton pumping. More details

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Product Overview

Online Datasheet in PDF
Product Name
UQCRB, Polyclonal Antibody
Full Product Name
UQCRB Antibody
Product Gene Name
anti-UQCRB antibody
Product Synonym Names
Complex III subunit 7; Complex III subunit VII; Cytochrome b-c1 complex subunit 7; MC3DN3; Mitochondrial ubiquinone-binding protein; QCR7; QCR7_HUMAN; QP-C; QPC; Ubiquinol cytochrome c reductase complex III subunit VI; Ubiquinol-cytochrome c reductase binding protein; Ubiquinol-cytochrome c reductase complex 14 kDa protein; Ubiquinone-binding protein; UQBC; UQBP; UQCR6; UQCRB; UQPC
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Peptide affinity purification
Concentration
1mg/ml (lot specific)
Specificity
UQCRB antibody detects endogenous levels of UQCRB.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Antibody/Peptide Pairs
UQCRB peptide (MBS9620884) is used for blocking the activity of UQCRB antibody (MBS9603407)
Molecular Weight
14 kDa
3D Structure
ModBase 3D Structure for P14927
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Immunogen
A synthesized peptide derived from human UQCRB, corresponding to a region within N-terminal amino acids.
Conjugation
Unconjugated
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-UQCRB antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-UQCRB antibody
WB: 1:500-1:2000
IHC: 1:50-1:200
IF/ICC: 1:100-1:500
The optimal dilutions should be determined by the end user.
IMPORTANT: For western blots, incubate membrane with diluted antibody in 5% w/v milk , 1X TBS, 0.1% Tween®20 at 4°C with gentle shaking, overnight.

Immunohistochemistry (IHC) of anti-UQCRB antibody

MBS9603407 at 1/100 staining Mouse kidney tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22 degree C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Rabbit Anti-UQCRB Polyclonal Antibody – Cat# MBS9603407

Western Blot (WB) of anti-UQCRB antibody

Western blot analysis of extracts of HeLa cells, using UQCRB antibody.
Rabbit Anti-UQCRB Polyclonal Antibody, Western Blot (WB) – Cat# MBS9603407

Immunohistochemistry (IHC) of anti-UQCRB antibody

MBS9603407 at 1/100 staining Mouse skin tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the primary antibody at 4°C overnight. An HRP conjugated anti-Rabbit antibody was used as the secondary antibody.
Rabbit Anti-UQCRB Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9603407

Immunofluorescence (IF) of anti-UQCRB antibody

MBS9603407 staining Hela cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25°C. Samples were then incubated with primary Ab(MBS9603407 1:200) and mouse antibeta tubulin Ab(MBS9610328 1:200) for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG(H+L) Ab(Red) and an AlexaFluor488 conjugated goat anti-mouse IgG(H+L) Ab(Green) were used as the secondary antibody.
Rabbit Anti-UQCRB Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS9603407

Other Notes

Small volumes of anti-UQCRB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for UQCRB purchase

MBS9603407 is an antibody targeting UQCRB. Also known as UQCRB Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for UQCRB. It may not necessarily be applicable to this product.

NCBI GI #
316983136
NCBI GeneID
7381
NCBI Accession #
NP_001186904.1
UniProt Primary Accession #
P14927
UniProt Secondary Accession #
Q6FGD1; E5RJU0
UniProt Related Accession #
P14927
GenBank Nucleotide #
NM_001199975.2
NCBI Official Full Name
cytochrome b-c1 complex subunit 7 isoform 2
NCBI Official Synonym Full Names
ubiquinol-cytochrome c reductase binding protein
NCBI Official Symbol
UQCRB
NCBI Official Synonym Symbols
QPC; QCR7; QP-C; UQBC; UQBP; UQPC; UQCR6; MC3DN3
UniProt Protein Name
Cytochrome b-c1 complex subunit 7
UniProt Synonym Protein Names
Complex III subunit 7; Complex III subunit VII; QP-C; Ubiquinol-cytochrome c reductase complex 14 kDa protein
Protein Family
Cytochrome b-c1 complex
UniProt Gene Name
UQCRB
UniProt Synonym Gene Names
UQBP
NCBI Protein Information
cytochrome b-c1 complex subunit 7

NCBI Summary for UQCRB

This gene encodes a subunit of the ubiquinol-cytochrome c oxidoreductase complex, which consists of one mitochondrial-encoded and 10 nuclear-encoded subunits. The protein encoded by this gene binds ubiquinone and participates in the transfer of electrons when ubiquinone is bound. This protein plays an important role in hypoxia-induced angiogenesis through mitochondrial reactive oxygen species-mediated signaling. Mutations in this gene are associated with mitochondrial complex III deficiency. Alternatively spliced transcript variants have been found for this gene. Related pseudogenes have been identified on chromosomes 1, 5 and X. [provided by RefSeq, Dec 2011]
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UniProt Comments for UQCRB

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This component is involved in redox-linked proton pumping.CautionWas originally thought to be the ubiquinone-binding protein (QP-C).

Research Articles on UQCRB

1. Our results provide novel insights into the critical role of UQCRB in regulating CRC, supporting UQCRB as a new candidate for the development of diagnostics for CRC patients.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-UQCRB antibody

 Products by Pathway  Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Cytochrome Bc1 Complex Pathway antibodies  Cytochrome Bc1 Complex Pathway Diagram
 Cytochrome Bc1 Complex Pathway antibodies  Cytochrome Bc1 Complex Pathway Diagram
 Electron Transport Chain Pathway antibodies  Electron Transport Chain Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram

Diseases associated with anti-UQCRB antibody

 Disease Name  Pubmed Publications
 MITOCHONDRIAL COMPLEX III DEFICIENCY Antibodies  >2 publications with UQCRB and MITOCHONDRIAL COMPLEX III DEFICIENCY
 Carcinoma Antibodies  >1 publications with UQCRB and Carcinoma
 Adenocarcinoma Antibodies  >1 publications with UQCRB and Adenocarcinoma
 Skin Diseases Antibodies  >1 publications with UQCRB and Skin Diseases
 Nervous System Diseases Antibodies  >1 publications with UQCRB and Nervous System Diseases
 Pancreatic Neoplasms Antibodies  >1 publications with UQCRB and Pancreatic Neoplasms
 Acidosis, Lactic Antibodies  >1 publications with UQCRB and Acidosis, Lactic
 Liver Diseases Antibodies  >1 publications with UQCRB and Liver Diseases
 Mitochondrial Diseases Antibodies  >1 publications with UQCRB and Mitochondrial Diseases
 Ovarian Neoplasms Antibodies  >1 publications with UQCRB and Ovarian Neoplasms

Organs/Tissues associated with anti-UQCRB antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >4 publications with UQCRB and Muscle
 Blood Antibodies  >2 publications with UQCRB and Blood
 Thyroid Antibodies  >1 publications with UQCRB and Thyroid
 Lymph Antibodies  >1 publications with UQCRB and Lymph
 Vascular Antibodies  >1 publications with UQCRB and Vascular
 Lymph Node Antibodies  >1 publications with UQCRB and Lymph Node
 Skin Antibodies  >1 publications with UQCRB and Skin
 Bone Antibodies  >1 publications with UQCRB and Bone
 Liver Antibodies  >1 publications with UQCRB and Liver
 Brain Antibodies  >1 publications with UQCRB and Brain
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