Baculovirus CDH5 Recombinant Protein – Cat# MBS206512

CDH5 Baculovirus Recombinant Protein

Name: CDH5 Recombinant Protein; Baculovirus; MyBioSource
Brand: MyBioSource
SKU: MBS206512
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS206512

CDH5, as known as cadherin-5, is a member of the atypical/type 2 subgroup of Cadherin homophilic adhesion proteins. This protein plays a role in the formation, maturation and remodeling of the vascular wall. It is widely considered to be specific for vascular… More details

$230 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CDH5, Recombinant Protein

Full Product Name

CDH5, 29-599aa, Human, hIgG-His-tag, Baculovirus

Product Gene Name

CDH5 recombinant protein

Product Synonym Names

Cadherin-5; CDH5; 7B4; CD144

Sequence

NPAQRDTHSL LPTHRRQKRD WIWNQMHIDE EKNTSLPHHV GKIKSSVSRK NAKYLLKGEY VGKVFRVDAE TGDVFAIERL DRENISEYHL TAVIVDKDTG ENLETPSSFT IKVHDVNDNW PVFTHRLFNA SVPESSAVGT SVISVTAVDA DDPTVGDHAS VMYQILKGKE YFAIDNSGRI ITITKSLDRE KQARYEIVVE ARDAQGLRGD SGTATVLVTL QDINDNFPFF TQTKYTFVVP EDTRVGTSVG SLFVEDPDEP QNRMTKYSIL RGDYQDAFTI ETNPAHNEGI IKPMKPLDYE YIQQYSFIVE ATDPTIDLRY MSPPAGNRAQ VIINITDVDE PPIFQQPFYH FQLKENQKKP LIGTVLAMDP DAARHSIGYS IRRTSDKGQF FRVTKKGDIY NEKELDREVY PWYNLTVEAK ELDSTGTPTG KESIVQVHIE VLDENDNAPE FAKPYQPKVC ENAVHGQLVL QISAIDKDIT PRNVKFKFIL NTENNFTLTD NHDNTANITV KYGQFDREHT KVHFLPVVIS DNGMPSRTGT STLTVAVCKC NEQGEFTFCE DMAAQVGVSI QLEPKSCDKT HTCPPCPAPE LLGGPSVFLF PPKPKDTLMI SRTPEVTCVV VDVSHEDPEV KFNWYVDGVE VHNAKTKPRE EQYNSTYRVV SVLTVLHQDW LNGKEYKCKV SNKALPAPIE KTISKAKGQP REPQVYTLPP SRDELTKNQV SLTCLVKGFY PSDIAVEWES NGQPENNYKT TPPVLDSDGS FFLYSKLTVD KSRWQQGNVF SCSVMHEALH NHYTQKSLSL SPGKHHHHHH

Host

Baculovirus

Form/Format

Liquid. In phosphate buffered saline (pH 7.4) containing 10% glycerol.

Purity/Purification

> 90% by SDS-PAGE

Concentration

0.5 mg/ml (determined by Absorbance at 280nm) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

91.5kDa (810aa) 70-100kDa (SDS-PAGE under reducing conditions.)

OMIM

X79981 mRNA

3D Structure

ModBase 3D Structure for P33151

Antigen Species

Human

Tag Information

hIgG-His-tag

Endotoxin Level

< 1.0 EU per 1 microgram of protein (determined by LAL method)

Product Categories/Family for CDH5 recombinant protein

Signal Transduction; Adhesion & Movement; Cytoskeleton

Applications Tested/Suitable for CDH5 recombinant protein

SDS-PAGE

Product References and Citations for CDH5 recombinant protein

Yan Z., et al, (2016) Arterioscler. Thromb. Vasc. Biol. 36:339-349.; Timmerman I., et al, (2015) J. Cell. Sci. 128:3041-3054.

Other Notes

Small volumes of CDH5 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CDH5 purchase

MBS206512 is a recombinant protein targeting CDH5. Also known as CDH5, 29-599aa, Human, hIgG-His-tag, Baculovirus. Host: Baculovirus.

Additional Details

NCBI/Uniprot data below describe general gene information for CDH5. It may not necessarily be applicable to this product.

NCBI GI #

166362713

NCBI GeneID

1003

NCBI Accession #

NP_001786

UniProt Primary Accession #

P33151

UniProt Secondary Accession #

Q4VAI5; Q4VAI6

UniProt Related Accession #

P33151

GenBank Nucleotide #

NM_001795.4

NCBI Official Full Name

cadherin-5 preproprotein

NCBI Official Synonym Full Names

cadherin 5

NCBI Official Symbol

CDH5

NCBI Official Synonym Symbols

7B4; CD144

UniProt Protein Name

Cadherin-5

UniProt Synonym Protein Names

7B4 antigen; Vascular endothelial cadherin; VE-cadherin; CD_antigen: CD144

Protein Family

Cadherin

UniProt Gene Name

CDH5

UniProt Synonym Gene Names

VE-cadherin

NCBI Protein Information

cadherin-5

NCBI Summary for CDH5

This gene encodes a classical cadherin of the cadherin superfamily. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion molecule is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classical cadherin by imparting to cells the ability to adhere in a homophilic manner, this protein plays a role in endothelial adherens junction assembly and maintenance. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. [provided by RefSeq, Nov 2015]

UniProt Comments for CDH5

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction.

Research Articles on CDH5

1. This study demonstrated that changes in gene expression of CDH5 and CLDN5 due to shear stress within individual differentiations also revealed no trend.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CDH5 recombinant protein

Reference Product	PubMed Publications
KDR recombinant protein	>7 publications with CDH5 and KDR
CDH13 recombinant protein	>4 publications with CDH5 and CDH13
RAC1 recombinant protein	>2 publications with CDH5 and RAC1
RHOA recombinant protein	>2 publications with CDH5 and RHOA
CTNNA1 recombinant protein	>1 publications with CDH5 and CTNNA1
CTNNB1 recombinant protein	>1 publications with CDH5 and CTNNB1

Pathways associated with CDH5 recombinant protein

Products by Pathway	Pathway Diagram
Adherens Junctions Interactions Pathway antibodies	Adherens Junctions Interactions Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Cell Junction Organization Pathway antibodies	Cell Junction Organization Pathway Diagram
Cell-Cell Communication Pathway antibodies	Cell-Cell Communication Pathway Diagram
Cell-cell Junction Organization Pathway antibodies	Cell-cell Junction Organization Pathway Diagram
Fluid Shear Stress And Atherosclerosis Pathway antibodies	Fluid Shear Stress And Atherosclerosis Pathway Diagram
Fluid Shear Stress And Atherosclerosis Pathway antibodies	Fluid Shear Stress And Atherosclerosis Pathway Diagram
Leukocyte Transendothelial Migration Pathway antibodies	Leukocyte Transendothelial Migration Pathway Diagram
Leukocyte Transendothelial Migration Pathway antibodies	Leukocyte Transendothelial Migration Pathway Diagram

Diseases associated with CDH5 recombinant protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>11 publications with CDH5 and Inflammation
Heart Diseases Antibodies	>10 publications with CDH5 and Heart Diseases
Lung Diseases Antibodies	>10 publications with CDH5 and Lung Diseases
Breast Neoplasms Antibodies	>9 publications with CDH5 and Breast Neoplasms
Fibrosis Antibodies	>6 publications with CDH5 and Fibrosis
Neoplasm Metastasis Antibodies	>6 publications with CDH5 and Neoplasm Metastasis
Hypertension Antibodies	>5 publications with CDH5 and Hypertension
Kidney Diseases Antibodies	>4 publications with CDH5 and Kidney Diseases
Liver Diseases Antibodies	>4 publications with CDH5 and Liver Diseases
Neoplasm Invasiveness Antibodies	>3 publications with CDH5 and Neoplasm Invasiveness

Organs/Tissues associated with CDH5 recombinant protein

Organ/Tissue Name	Pubmed Publications
Vascular Antibodies	>67 publications with CDH5 and Vascular
Heart Antibodies	>21 publications with CDH5 and Heart
Muscle Antibodies	>17 publications with CDH5 and Muscle
Lung Antibodies	>16 publications with CDH5 and Lung
Embryonic Tissue Antibodies	>16 publications with CDH5 and Embryonic Tissue
Bone Antibodies	>9 publications with CDH5 and Bone
Brain Antibodies	>8 publications with CDH5 and Brain
Kidney Antibodies	>7 publications with CDH5 and Kidney
Nerve Antibodies	>5 publications with CDH5 and Nerve
Umbilical Cord Antibodies	>4 publications with CDH5 and Umbilical Cord