Rabbit Anti-XYLT2 Polyclonal Antibody – Cat# MBS2067065

Knockout Validation: Lane 1: Wild-type Hela cell lysate; Lane 2: XYLT2 knockout Hela cell lysate; Predicted MW: 97kd Observed MW: 95kd Primary Ab: 1ug/ml Rabbit Anti-Mouse XYLT2 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047)

Xylosyltransferase II (XYLT2) Antibody – Rabbit Polyclonal

Name: XYLT2 Antibody; Polyclonal; Rabbit; Mouse/Human/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS2067065
Price: 275 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2067065

MBS2067065 is an antibody targeting XYLT2. Also known as FITC-Linked Polyclonal Antibody to Xylosyltransferase II (XYLT2). Reactive in Mouse, Human, Rat. Host: Rabbit. More details

$275 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Xylosyltransferase II (XYLT2), Polyclonal Antibody

Full Product Name

FITC-Linked Polyclonal Antibody to Xylosyltransferase II (XYLT2)

Product Gene Name

anti-XYLT2 antibody

Product Synonym Names

XT-II; XT2; xylT-II; PXYLT2; Protein Xylosyltransferase 2; Peptide O-xylosyltransferase 1

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Mouse, Human, Rat

Concentration

500ug/ml (lot specific)

Matching Pairs

Unconjugated Antibody: XYLT2 (MBS2032403)
FITC Conjugated Antibody: XYLT2 (MBS2067065)

Matching Pairs

FITC Conjugated Antibody: XYLT2 (MBS2067065)
Immunogen: XYLT2 (MBS2033503)

Molecular Weight

71,115 Da

OMIM

AJ277442 mRNA

Supply Chain Verification

Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.

Immunogen

XYLT2 (Phe596~Arg865)

Conjugation

FITC

Cross Reactivity

Human, Mouse

Unconjugated Antibody

The unconjugated antibody version of this item is also available as catalog #MBS2032403

ISO Certification

Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.

Applications Tested/Suitable for anti-XYLT2 antibody

Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA)

Other Notes

Small volumes of anti-XYLT2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for XYLT2. It may not necessarily be applicable to this product.

NCBI GI #

11322270

NCBI GeneID

64132

NCBI Accession #

CAC16788.1

UniProt Secondary Accession #

Q6UY41; Q86V00

UniProt Related Accession #

Q9H1B5

NCBI Official Full Name

xylosyltransferase II

NCBI Official Synonym Full Names

xylosyltransferase 2

NCBI Official Symbol

XYLT2

NCBI Official Synonym Symbols

SOS; XT2; XT-II; PXYLT2; xylT-II

UniProt Protein Name

Xylosyltransferase 2

UniProt Synonym Protein Names

Peptide O-xylosyltransferase 1; Xylosyltransferase II; XT-II; XylT-II

Protein Family

Xylosyltransferase

UniProt Gene Name

XYLT2

UniProt Synonym Gene Names

XT2; XT-II; XylT-II

NCBI Protein Information

xylosyltransferase 2

NCBI Summary for XYLT2

The protein encoded by this gene is an isoform of xylosyltransferase, which belongs to a family of glycosyltransferases. This enzyme transfers xylose from UDP-xylose to specific serine residues of the core protein and initiates the biosynthesis of glycosaminoglycan chains in proteoglycans including chondroitin sulfate, heparan sulfate, heparin and dermatan sulfate. The enzyme activity, which is increased in scleroderma patients, is a diagnostic marker for the determination of sclerotic activity in systemic sclerosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]

UniProt Comments for XYLT2

XYLT2: Probably catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes. Its enzyme activity has not been demonstrated. Belongs to the glycosyltransferase 14 family. XylT subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.4.2.26; Glycan Metabolism - chondroitin sulfate biosynthesis; Glycan Metabolism - heparan sulfate biosynthesis; Membrane protein, integral; Transferase

Chromosomal Location of Human Ortholog: 17q21.33

Biological Process: chondroitin sulfate proteoglycan biosynthetic process; heparan sulfate proteoglycan biosynthetic process

Disease: Pseudoxanthoma Elasticum; Spondyloocular Syndrome

Research Articles on XYLT2

1. Homozygosity for frameshift mutations in XYLT2 result in a spondylo-ocular syndrome with bone fragility, cataracts, and hearing defects.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-XYLT2 antibody

Reference Product	PubMed Publications
HS6ST1 antibody	>1 publications with XYLT2 and HS6ST1

Pathways associated with anti-XYLT2 antibody

Products by Pathway	Pathway Diagram
Glycosaminoglycan Biosynthesis - Chondroitin Sulfate / Dermatan Sulfate Pathway antibodies	Glycosaminoglycan Biosynthesis - Chondroitin Sulfate / Dermatan Sulfate Pathway Diagram
Glycosaminoglycan Biosynthesis - Chondroitin Sulfate / Dermatan Sulfate Pathway antibodies	Glycosaminoglycan Biosynthesis - Chondroitin Sulfate / Dermatan Sulfate Pathway Diagram
Glycosaminoglycan Biosynthesis - Heparan Sulfate / Heparin Pathway antibodies	Glycosaminoglycan Biosynthesis - Heparan Sulfate / Heparin Pathway Diagram
Glycosaminoglycan Biosynthesis - Heparan Sulfate / Heparin Pathway antibodies	Glycosaminoglycan Biosynthesis - Heparan Sulfate / Heparin Pathway Diagram
Glycosaminoglycan Biosynthesis, Linkage Tetrasaccharide Pathway antibodies	Glycosaminoglycan Biosynthesis, Linkage Tetrasaccharide Pathway Diagram
Glycosaminoglycan Biosynthesis, Linkage Tetrasaccharide Pathway antibodies	Glycosaminoglycan Biosynthesis, Linkage Tetrasaccharide Pathway Diagram
Metabolic Pathways antibodies	Metabolic Pathways Diagram
Chondroitin Sulfate Biosynthesis Pathway antibodies	Chondroitin Sulfate Biosynthesis Pathway Diagram
Chondroitin Sulfate Biosynthesis Pathway antibodies	Chondroitin Sulfate Biosynthesis Pathway Diagram
Dermatan Sulfate Biosynthesis Pathway antibodies	Dermatan Sulfate Biosynthesis Pathway Diagram

Diseases associated with anti-XYLT2 antibody

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>2 publications with XYLT2 and Cardiovascular Diseases
Kidney Diseases Antibodies	>2 publications with XYLT2 and Kidney Diseases
Fibrosis Antibodies	>2 publications with XYLT2 and Fibrosis
Neurologic Manifestations Antibodies	>1 publications with XYLT2 and Neurologic Manifestations
Heart Diseases Antibodies	>1 publications with XYLT2 and Heart Diseases
Nervous System Diseases Antibodies	>1 publications with XYLT2 and Nervous System Diseases
Neoplasm Metastasis Antibodies	>1 publications with XYLT2 and Neoplasm Metastasis
Immune System Diseases Antibodies	>1 publications with XYLT2 and Immune System Diseases
Learning Disorders Antibodies	>1 publications with XYLT2 and Learning Disorders
Liver Neoplasms Antibodies	>1 publications with XYLT2 and Liver Neoplasms

Organs/Tissues associated with anti-XYLT2 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>6 publications with XYLT2 and Blood
Skin Antibodies	>3 publications with XYLT2 and Skin
Muscle Antibodies	>2 publications with XYLT2 and Muscle
Bone Antibodies	>2 publications with XYLT2 and Bone
Ovary Antibodies	>1 publications with XYLT2 and Ovary
Kidney Antibodies	>1 publications with XYLT2 and Kidney
Eye Antibodies	>1 publications with XYLT2 and Eye
Vascular Antibodies	>1 publications with XYLT2 and Vascular