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IL15RA Baculovirus Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS206722

IL15RA, also known as interleukin-15 receptor subunit alpha isoform 1, is a high-affinity receptor for interleukin-15. It associates as a heterotrimer with the IL-2 receptor beta and gamma subunits to initiate signal transduction. This protein can signal both… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
IL15RA, Active Protein
Full Product Name
IL15RA, 31-205aa, Human, hIgG-His-tag, Baculovirus
Product Gene Name
Product Synonym Names
Interleukin-15 receptor subunit alpha isoform 1; IL15RA; CD215
Sequence
ADPITCPPPM SVEHADIWVK SYSLYSRERY ICNSGFKRKA GTSSLTECVL NKATNVAHWT TPSLKCIRDP ALVHQRPAPP STVTTAGVTP QPESLSPSGK EPAASSPSSN NTAATTAAIV PGSQLMPSKS PSTGTTEISS HESSHGTPSQ TTAKNWELTA SASHQPPGVY PQGHSDTTLE PKSCDKTHTC PPCPAPELLG GPSVFLFPPK PKDTLMISRT PEVTCVVVDV SHEDPEVKFN WYVDGVEVHN AKTKPREEQY NSTYRVVSVL TVLHQDWLNG KEYKCKVSNK ALPAPIEKTI SKAKGQPREP QVYTLPPSRD ELTKNQVSLT CLVKGFYPSD IAVEWESNGQ PENNYKTTPP VLDSDGSFFL YSKLTVDKSR WQQGNVFSCS VMHEALHNHY TQKSLSLSPG KHHHHHH
Host
Baculovirus
Form/Format
Liquid. In phosphate buffered saline (pH 7.4) containing 10% glycerol.
Purity/Purification
> 90% by SDS-PAGE
Concentration
0.5 mg/ml (determined by Absorbance at 280nm) (lot specific)
Preparation and Storage
Store at -20 degree C or -70 degree C. Aliquot into individual use vials to avoid repeated freeze/thaw cycles.
Molecular Weight
45.6 kDa (417aa)
OMIM
U31628 mRNA
3D Structure
ModBase 3D Structure for Q13261
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Antigen Species
Human
Tag Information
hIgG-His-tag
Endotoxin Level
< 1.0 EU per 1ug of protein (determined by LAL method)
Activity
Measured by its ability to inhibit proliferation using CTLL2 mouse cytotoxic T cells. The ED50 for this effect is <=2ng/ml with Human IL-15.
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.

Product Categories/Family for IL15RA active protein

Applications Tested/Suitable for IL15RA active protein
SDS-PAGE, Bioactivity

SDS-Page of IL15RA active protein

3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain.
Baculovirus IL15RA Active Protein – Cat# MBS206722

Biological Activity of IL15RA active protein

Human IL-15 R alpha inhibits Human IL-15 induced cell proliferation in the CTLL2 mouse cytotoxic T cells. The ED50 range ?2 ng/ml
Baculovirus IL15RA Active Protein, Biological Activity – Cat# MBS206722

Product References and Citations for IL15RA active protein

Epardaud M., et al, (2008) Cancer Res. 68:2972-2983.; Stoklasek TA., et al, (2006) J Immunol. 177:6072-6080.

Other Notes

Small volumes of IL15RA active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL15RA purchase

MBS206722 is an active protein targeting IL15RA. Also known as IL15RA, 31-205aa, Human, hIgG-His-tag, Baculovirus. Host: Baculovirus.

Additional Details

NCBI/Uniprot data below describe general gene information for IL15RA. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
interleukin-15 receptor subunit alpha isoform 1
NCBI Official Synonym Full Names
interleukin 15 receptor subunit alpha
NCBI Official Symbol
IL15RA
NCBI Official Synonym Symbols
CD215
UniProt Protein Name
Interleukin-15 receptor subunit alpha
UniProt Synonym Protein Names
CD_antigen: CD215
UniProt Gene Name
IL15RA
UniProt Synonym Gene Names
IL-15 receptor subunit alpha; IL-15R-alpha; IL-15RA; sIL-15 receptor subunit alpha; sIL-15R-alpha; sIL-15RA
NCBI Protein Information
interleukin-15 receptor subunit alpha

NCBI Summary for IL15RA

This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptors of IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the basis of many overlapping biological activities of IL15 and IL2. The protein encoded by this gene is structurally related to IL2R alpha, an additional IL2-specific alpha subunit necessary for high affinity IL2 binding. Unlike IL2RA, IL15RA is capable of binding IL15 with high affinity independent of other subunits, which suggests distinct roles between IL15 and IL2. This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiple alternatively spliced transcript variants of this gene have been reported.[provided by RefSeq, Apr 2010]
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UniProt Comments for IL15RA

High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Expression of different isoforms may alter or interfere with signal transduction. Isoform 5, isoform 6, isoform 7 and isoform 8 do not bind IL15. Signal transduction involves SYK.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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