Myosin Ic (MYO1C) Antibody – Rabbit Polyclonal

This gene encodes a member of the unconventional myosin protein family, which are actin-based molecular motors. The protein is found in the cytoplasm, and one isoform with a unique N-terminus is also found in the nucleus. The nuclear isoform associates with RNA polymerase I and II and functions in transcription initiation. The mouse ortholog of this protein also functions in intracellular vesicle transport to the plasma membrane. Multiple transcript variants encoding different isoforms have been found for this gene. The related gene myosin IE has been referred to as myosin IC in the literature, but it is a distinct locus on chromosome 19. [provided by RefSeq, Jul 2008]

MYO1C: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Actin-binding; Contractile; Lipid-binding; Motility/polarity/chemotaxis; Motor; Nucleolus

Chromosomal Location of Human Ortholog: 17p13.3

Cellular Component: basal plasma membrane; cytoplasm; cytosol; filamentous actin; lateral plasma membrane; lipid raft; membrane; microvillus; nucleoplasm; plasma membrane; stress fiber; unconventional myosin complex

Molecular Function: protein binding; Ral GTPase binding; receptor binding

Biological Process: positive regulation of cell migration; positive regulation of gene expression, epigenetic; protein targeting; protein targeting to membrane