Rabbit Anti-NIS Polyclonal Antibody – Cat# MBS2074487

Sodium Iodide Symporter (NIS) Antibody – Rabbit Polyclonal

Name: NIS Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS2074487
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2074487

MBS2074487 is an antibody targeting NIS. Also known as HRP-Linked Polyclonal Antibody to Sodium Iodide Symporter (NIS). Reactive in Human. Host: Rabbit. More details

$250 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Sodium Iodide Symporter (NIS), Polyclonal Antibody

Full Product Name

HRP-Linked Polyclonal Antibody to Sodium Iodide Symporter (NIS)

Product Gene Name

anti-NIS antibody

Product Synonym Names

SLC5A5; Solute Carrier Family 5 Member 5; Na (+)/I (-) cotransporter

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as solution form in PBS, pH7.4, 50% glycerol; 0.05% Proclin-300.

Purity/Purification

Antigen-specific Affinity Chromatography.

Concentration

1mg/ml (lot specific)

Preparation and Storage

Storage:
Avoid repeated freeze/thaw cycles.
Store at 4 degree C for frequent use.
Aliquot and store at -20 degree C for 24 months.

Stability Test:
thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Matching Pairs

Unconjugated Antibody: NIS (MBS2026331)
HRP Conjugated Antibody: NIS (MBS2074487)

Matching Pairs

HRP Conjugated Antibody: NIS (MBS2074487)
Immunogen: NIS (MBS2031325)

OMIM

U66088 mRNA

Supply Chain Verification

Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.

Source

Antibody labeling

Label

HRP

Unconjugated Antibody

MBS2026331

Traits

Liquid

Immunogen

Recombinant NIS (Ser547~Leu643) expressed in E.coli (MBS2031325).

ISO Certification

Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.

Applications Tested/Suitable for anti-NIS antibody

Western Blot (WB); Immunohistochemistry (IHC); Immunocytochemistry (ICC); Immunoprecipitation (IP).

Application Notes for anti-NIS antibody

Western blotting: 0.5-2ug/mL
Immunohistochemistry: 5-20ug/mL
Immunocytochemistry: 5-20ug/mL
Optimal working dilutions must be determined by end user.

Other Notes

Small volumes of anti-NIS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for NIS. It may not necessarily be applicable to this product.

NCBI GI #

1628579

NCBI GeneID

6528

NCBI Accession #

AAB17378.1

UniProt Secondary Accession #

O43702; Q2M335; Q9NYB6

UniProt Related Accession #

Q92911

NCBI Official Full Name

sodium iodide symporter

NCBI Official Synonym Full Names

solute carrier family 5 member 5

NCBI Official Symbol

SLC5A5

NCBI Official Synonym Symbols

NIS; TDH1

UniProt Protein Name

Sodium/iodide cotransporter

UniProt Synonym Protein Names

Sodium-iodide symporter; Na(+)/I(-) symporter; Solute carrier family 5 member 5

UniProt Gene Name

SLC5A5

UniProt Synonym Gene Names

NIS; Na(+)/I(-) cotransporter; Na(+)/I(-) symporter

NCBI Protein Information

sodium/iodide cotransporter

NCBI Summary for NIS

This gene encodes a member of the sodium glucose cotransporter family. The encoded protein is responsible for the uptake of iodine in tissues such as the thyroid and lactating breast tissue. The iodine taken up by the thyroid is incorporated into the metabolic regulators triiodothyronine (T3) and tetraiodothyronine (T4). Mutations in this gene are associated with thyroid dyshormonogenesis 1.[provided by RefSeq, Sep 2009]

UniProt Comments for NIS

SLC5A5: Mediates iodide uptake in the thyroid gland. Defects in SLC5A5 are the cause of thyroid dyshormonogenesis 1 (TDH1). A disorder characterized by the inability of the thyroid to maintain a concentration difference of readily exchangeable iodine between the plasma and the thyroid gland, leading to congenital hypothyroidism. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family

Chromosomal Location of Human Ortholog: 19p13.11

Cellular Component: integral to membrane; integral to plasma membrane; nucleus; plasma membrane

Molecular Function: iodide transmembrane transporter activity; sodium:iodide symporter activity

Biological Process: iodide transport; ion transport; thyroid hormone generation; transport

Disease: Thyroid Dyshormonogenesis 1

Research Articles on NIS

1. Mutating the sites located on the C-terminal domain of the protein has no effect except for the creation of a diacidic motif that decreases the total NIS protein level without affecting its expression at the plasma membrane.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-NIS antibody

Products by Pathway	Pathway Diagram
Amine-derived Hormones Pathway antibodies	Amine-derived Hormones Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Amino Acids And Derivatives Pathway antibodies	Metabolism Of Amino Acids And Derivatives Pathway Diagram
Organic Anion Transporters Pathway antibodies	Organic Anion Transporters Pathway Diagram
SLC-mediated Transmembrane Transport Pathway antibodies	SLC-mediated Transmembrane Transport Pathway Diagram
Thyroid Hormone Synthesis Pathway antibodies	Thyroid Hormone Synthesis Pathway Diagram
Thyroid Hormone Synthesis Pathway antibodies	Thyroid Hormone Synthesis Pathway Diagram
Thyroxine (Thyroid Hormone) Production Pathway antibodies	Thyroxine (Thyroid Hormone) Production Pathway Diagram
Thyroxine Biosynthesis Pathway antibodies	Thyroxine Biosynthesis Pathway Diagram
Transmembrane Transport Of Small Molecules Pathway antibodies	Transmembrane Transport Of Small Molecules Pathway Diagram

Diseases associated with anti-NIS antibody

Disease Name	Pubmed Publications
Thyroid Diseases Antibodies	>10 publications with NIS and Thyroid Diseases
Thyroid Neoplasms Antibodies	>8 publications with NIS and Thyroid Neoplasms
Liver Diseases Antibodies	>2 publications with NIS and Liver Diseases
Breast Neoplasms Antibodies	>2 publications with NIS and Breast Neoplasms
Prenatal Injuries Antibodies	>1 publications with NIS and Prenatal Injuries
Prenatal Exposure Delayed Effects Antibodies	>1 publications with NIS and Prenatal Exposure Delayed Effects
Prostatic Neoplasms Antibodies	>1 publications with NIS and Prostatic Neoplasms
Carcinoma, Hepatocellular Antibodies	>1 publications with NIS and Carcinoma, Hepatocellular
Liver Neoplasms Antibodies	>1 publications with NIS and Liver Neoplasms
Cognition Disorders Antibodies	>1 publications with NIS and Cognition Disorders

Organs/Tissues associated with anti-NIS antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>6 publications with NIS and Brain
Muscle Antibodies	>1 publications with NIS and Muscle