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Adenosylhomocysteinase (AHCY) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2096194
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MBS2096194 is an antibody targeting AHCY. Also known as Biotin-Linked Polyclonal Antibody to Adenosylhomocysteinase (AHCY). Reactive in Human, Mouse, Rat. Host: Rabbit. More details

$225 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Adenosylhomocysteinase (AHCY), Polyclonal Antibody
Full Product Name
Biotin-Linked Polyclonal Antibody to Adenosylhomocysteinase (AHCY)
Product Gene Name
anti-AHCY antibody
Product Synonym Names
SAHH; AdoHcyase; S-Adenosylhomocysteine Hydrolase; S-adenosyl-L-homocysteine hydrolase
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Concentration
500ug/ml (lot specific)
Matching Pairs
Unconjugated Antibody: AHCY (MBS2027516)
Biotin Conjugated Antibody: AHCY (MBS2096194)
Matching Pairs
Biotin Conjugated Antibody: AHCY (MBS2096194)
Immunogen: AHCY (MBS2030910)
Molecular Weight
47,538 Da
3D Structure
ModBase 3D Structure for P10760
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Conjugation
Biotin
Cross Reactivity
Human
Immunogen
AHCY (Ser2~Tyr432)
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-AHCY antibody
Western Blot (WB), Immunohistochemistry (IHC)

Other Notes

Small volumes of anti-AHCY antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for AHCY. It may not necessarily be applicable to this product.

NCBI GI #
8392878
NCBI GeneID
29443
NCBI Accession #
NP_058897.1
UniProt Primary Accession #
P10760
UniProt Related Accession #
P10760
GenBank Nucleotide #
NM_017201.1
NCBI Official Full Name
adenosylhomocysteinase
NCBI Official Synonym Full Names
adenosylhomocysteinase
NCBI Official Symbol
Ahcy
UniProt Protein Name
Adenosylhomocysteinase
UniProt Synonym Protein Names
S-adenosyl-L-homocysteine hydrolase
Protein Family
Adenosylhomocysteinase
UniProt Gene Name
Ahcy
UniProt Synonym Gene Names
AdoHcyase
NCBI Protein Information
adenosylhomocysteinase

NCBI Summary for AHCY

enzyme that catalyzes the hydrolysis of S-adenosylhomocysteine to form adenosine and homocysteine [RGD, Feb 2006]

UniProt Comments for AHCY

SAHH: Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine. Defects in AHCY are the cause of hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD). A metabolic disorder characterized by hypermethioninemia associated with failure to thrive, mental and motor retardation, facial dysmorphism with abnormal hair and teeth, and myocardiopathy. Belongs to the adenosylhomocysteinase family.

Protein type: Amino Acid Metabolism - cysteine and methionine; EC 3.3.1.1; Hydrolase; Other Amino Acids Metabolism - selenoamino acid

Chromosomal Location of Human Ortholog: 3q41

Cellular Component: cytosol; melanosome; neuron projection; nucleus

Molecular Function: adenosylhomocysteinase activity; adenyl nucleotide binding; copper ion binding; identical protein binding; NAD binding; protein self-association

Biological Process: chronic inflammatory response to antigenic stimulus; circadian sleep/wake cycle; one-carbon metabolic process; response to hypoxia; response to nutrient; S-adenosylhomocysteine catabolic process; S-adenosylmethionine cycle; selenium compound metabolic process
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Research Articles on AHCY

1. report that Myc promotes upregulation of S-adenosyl homocysteine hydrolase.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-AHCY antibody

 Reference Product  PubMed Publications
 Cbs antibody  >9 publications with AHCY and Cbs
 Mat1a antibody  >8 publications with AHCY and Mat1a
 Bhmt antibody  >7 publications with AHCY and Bhmt
 Mat2a antibody  >5 publications with AHCY and Mat2a
 Mtrr antibody  >4 publications with AHCY and Mtrr
 Mtr antibody  >4 publications with AHCY and Mtr
 Dnmt3b antibody  >3 publications with AHCY and Dnmt3b
 Dnmt1 antibody  >3 publications with AHCY and Dnmt1

Pathways associated with anti-AHCY antibody

 Products by Pathway  Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Cysteine And Methionine Metabolism Pathway antibodies  Cysteine And Methionine Metabolism Pathway Diagram
 Cysteine And Methionine Metabolism Pathway antibodies  Cysteine And Methionine Metabolism Pathway Diagram
 L-methionine Degradation I (to L-homocysteine) Pathway antibodies  L-methionine Degradation I (to L-homocysteine) Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Methionine Degradation Pathway antibodies  Methionine Degradation Pathway Diagram
 Methionine Degradation Pathway antibodies  Methionine Degradation Pathway Diagram
 Methylation Pathway antibodies  Methylation Pathway Diagram

Diseases associated with anti-AHCY antibody

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >29 publications with AHCY and Disease Models, Animal
 Nervous System Diseases Antibodies  >23 publications with AHCY and Nervous System Diseases
 Brain Diseases Antibodies  >22 publications with AHCY and Brain Diseases
 Liver Diseases Antibodies  >22 publications with AHCY and Liver Diseases
 Cardiovascular Diseases Antibodies  >21 publications with AHCY and Cardiovascular Diseases
 Neoplasms, Experimental Antibodies  >18 publications with AHCY and Neoplasms, Experimental
 Amino Acid Metabolism, Inborn Errors Antibodies  >13 publications with AHCY and Amino Acid Metabolism, Inborn Errors
 Necrosis Antibodies  >12 publications with AHCY and Necrosis
 Liver Neoplasms Antibodies  >10 publications with AHCY and Liver Neoplasms
 Hepatitis Antibodies  >10 publications with AHCY and Hepatitis

Organs/Tissues associated with anti-AHCY antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >159 publications with AHCY and Liver
 Brain Antibodies  >40 publications with AHCY and Brain
 Kidney Antibodies  >29 publications with AHCY and Kidney
 Placenta Antibodies  >25 publications with AHCY and Placenta
 Heart Antibodies  >17 publications with AHCY and Heart
 Spleen Antibodies  >15 publications with AHCY and Spleen
 Lung Antibodies  >11 publications with AHCY and Lung
 Colon Antibodies  >10 publications with AHCY and Colon
 Thymus Antibodies  >10 publications with AHCY and Thymus
 Embryonic Tissue Antibodies  >8 publications with AHCY and Embryonic Tissue
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