LAMININ ALPHA 5 Antibody – Mouse Monoclonal

This gene encodes one of the vertebrate laminin alpha chains. Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. The protein encoded by this gene is the alpha-5 subunit of of laminin-10 (laminin-511), laminin-11 (laminin-521) and laminin-15 (laminin-523). [provided by RefSeq, Jun 2013]

LAMA5: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

Protein type: Secreted, signal peptide; Secreted; Extracellular matrix; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 20q13.2-q13.3

Cellular Component: extracellular matrix; extracellular space; laminin-5 complex; laminin-1 complex; laminin-10 complex; extracellular region; basement membrane; basal lamina; nucleus

Molecular Function: integrin binding; structural molecule activity

Biological Process: integrin-mediated signaling pathway; focal adhesion formation; regulation of cell adhesion; endothelial cell differentiation; muscle development; extracellular matrix organization and biogenesis; cell migration; regulation of embryonic development; cytoskeleton organization and biogenesis; cell recognition; regulation of cell migration; regulation of cell proliferation; odontogenesis of dentine-containing teeth; extracellular matrix disassembly; cell proliferation; embryonic development; morphogenesis of embryonic epithelium; hair follicle development; ureteric bud branching; cilium biogenesis; angiogenesis; cell differentiation; neural crest cell migration; morphogenesis of a polarized epithelium; lung development