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CD6 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS210795

Mouse anti Human CD6 antibody, clone MEM-98 recognizes human CD6, also known as T12 or TP120. CD6 is a ~100-130kDa type 1 single pass trans-membrane protein member of the immunoglobulin superfamily. CD6 possesses 3 scavenger receptor cysteine rich (SRCR)… More details

$510 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD6, Monoclonal Antibody
Full Product Name
MOUSE ANTI HUMAN CD6:FITC
Product Gene Name
anti-CD6 antibody
Clonality
Monoclonal
Isotype
IgG1
Clone Number
MEM-98
Host
Mouse
Form/Format
FITC
Purified IgG conjugated to Fluorescein Isothiocyanate Isomer 1 (FITC) - liquid
Concentration
IgG concentration 0.1mg/ml (lot specific)
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Molecular Weight
60,572 Da
OMIM
186720
3D Structure
ModBase 3D Structure for P30203
Perservative Stabilisers
0.09% Sodium Azide
1% Bovine Serum Albumin
Preparation||Purified IgG prepared by affinity chromatography on Protein G
Buffer Solution
Phosphate buffered saline
Target Species
Human
Applications Tested/Suitable for anti-CD6 antibody
Flow cytometry (FC/FACS)
Application Notes for anti-CD6 antibody
Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells or 100ul whole blood
Flow Cytometry: Maximum Dilution: Neat

Testing Data of anti-CD6 antibody

Staining of human peripheral blood lymphocytes with Mouse anti Human CD6 (MBS212366)
Mouse Anti-CD6 Monoclonal Antibody – Cat# MBS210795

Testing Data of anti-CD6 antibody

Staining of human peripheral blood lymphocytes with Mouse anti Human CD6:FITC
Mouse Anti-CD6 Monoclonal Antibody, Testing Data – Cat# MBS210795

Testing Data of anti-CD6 antibody

Staining of human peripheral blood lymphocytes with Mouse anti Human CD6:RPE (MBS213686)
Mouse Anti-CD6 Monoclonal Antibody, Testing Data – Cat# MBS210795

Other Notes

Small volumes of anti-CD6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD6 purchase

MBS210795 is an antibody targeting CD6. Also known as MOUSE ANTI HUMAN CD6:FITC. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CD6. It may not necessarily be applicable to this product.

NCBI GI #
363543322
NCBI GeneID
923
NCBI Accession #
NP_001241679.1
UniProt Primary Accession #
P30203
UniProt Secondary Accession #
Q9UMF2; Q9Y4K7; Q9Y4K8; Q9Y4K9; Q9Y4L0; A4KAD4; A4KAD5
UniProt Related Accession #
P30203
GenBank Nucleotide #
NM_001254750.1
NCBI Official Full Name
T-cell differentiation antigen CD6 isoform 2
NCBI Official Synonym Full Names
CD6 molecule
NCBI Official Symbol
CD6
NCBI Official Synonym Symbols
TP120
UniProt Protein Name
T-cell differentiation antigen CD6
UniProt Synonym Protein Names
T12; TP120; CD_antigen: CD6
Protein Family
T-cell differentiation antigen
UniProt Gene Name
CD6
UniProt Entry Name
CD6_HUMAN
NCBI Protein Information
T-cell differentiation antigen CD6; CD6 antigen; T12

NCBI Summary for CD6

This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
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UniProt Comments for CD6

CD6: a type I membrane protein involved in cell adhesion. Binds to CD166. Expressed on thymocytes, peripheral T cells, a subset of B cells, and a subset of neurons. Mediates the binding of developing thymocytes with thymic epithelial cells. CD6- T cells are less autoreactive than CD6+ T cells. Phosphorylated on tyrosines and serines following T cell antigen receptor signaling. Five splice-variant isoforms have been described.

Protein type: Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: integral to plasma membrane

Molecular Function: protein binding; scavenger receptor activity

Biological Process: receptor-mediated endocytosis; cell adhesion
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Research Articles on CD6

1. interaction of Galectin-1 and -3 with CD6

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD6 antibody

 Reference Product  PubMed Publications
 CD5 antibody  >104 publications with CD6 and CD5
 CD2 antibody  >78 publications with CD6 and CD2
 ALCAM antibody  >64 publications with CD6 and ALCAM
 CD7 antibody  >40 publications with CD6 and CD7
 LCK antibody  >6 publications with CD6 and LCK
 CD27 antibody  >5 publications with CD6 and CD27
 SDCBP antibody  >2 publications with CD6 and SDCBP

Pathways associated with anti-CD6 antibody

 Products by Pathway  Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram

Diseases associated with anti-CD6 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >19 publications with CD6 and Inflammation
 Multiple Sclerosis Antibodies  >19 publications with CD6 and Multiple Sclerosis
 Necrosis Antibodies  >13 publications with CD6 and Necrosis
 Carcinoma Antibodies  >10 publications with CD6 and Carcinoma
 Vascular Diseases Antibodies  >7 publications with CD6 and Vascular Diseases
 Lung Diseases Antibodies  >6 publications with CD6 and Lung Diseases
 Adenocarcinoma Antibodies  >5 publications with CD6 and Adenocarcinoma
 Ovarian Diseases Antibodies  >3 publications with CD6 and Ovarian Diseases
 Kidney Diseases Antibodies  >3 publications with CD6 and Kidney Diseases
 Abnormalities, Drug-Induced Antibodies  >2 publications with CD6 and Abnormalities, Drug-Induced

Organs/Tissues associated with anti-CD6 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >250 publications with CD6 and Blood
 Thymus Antibodies  >26 publications with CD6 and Thymus
 Lymph Node Antibodies  >22 publications with CD6 and Lymph Node
 Spleen Antibodies  >15 publications with CD6 and Spleen
 Brain Antibodies  >14 publications with CD6 and Brain
 Intestine Antibodies  >12 publications with CD6 and Intestine
 Lung Antibodies  >9 publications with CD6 and Lung
 Eye Antibodies  >8 publications with CD6 and Eye
 Thyroid Antibodies  >5 publications with CD6 and Thyroid
 Kidney Antibodies  >5 publications with CD6 and Kidney
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