Mouse Anti-AST Monoclonal Antibody – Cat# MBS2120702

Aspartate Aminotransferase (AST) Antibody – Mouse Monoclonal

Name: AST Antibody; Monoclonal; Mouse; Human/Mouse/Rat/Pig-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS2120702
Price: 335 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2120702

MBS2120702 is an antibody targeting AST. Also known as Cy3-Linked Monoclonal Antibody to Aspartate Aminotransferase (AST). Reactive in Human, Mouse, Rat, Pig. Host: Mouse. More details

$335 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Aspartate Aminotransferase (AST), Monoclonal Antibody

Full Product Name

Cy3-Linked Monoclonal Antibody to Aspartate Aminotransferase (AST)

Product Gene Name

anti-AST antibody

Product Synonym Names

cCAT; AAT; ASAT; SGOT; GOT1; Cysteine transaminase, cytoplasmic; Transaminase A; Aspartate Transaminase 1,Cytoplasmic; Glutamic-Oxaloacetic Transaminase 1,Soluble

Immunogen Sequence

Met1~Gln41 3

Clonality

Monoclonal

Isotype

IgG2b Kappa

Clone Number

Host

Mouse

Species Reactivity

Human, Mouse, Rat, Pig

Form/Format

Liquid; 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.

Purity/Purification

Protein A + Protein G Affinity Chromatography

Concentration

>=100ug/ml (lot specific)

Specificity

The antibody is a mouse monoclonal antibody raised against AST. It has been selected for its ability to recognize AST in immunohistochemical staining and western blotting.

Preparation and Storage

Store at 4 degree C for frequent use. Aliquot and store at -20 degree C for 12 months.
Avoid repeated freeze/thaw cycles.
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Matching Pairs

Unconjugated Antibody: AST Clone #C2 (MBS2111221)
Cy3 Conjugated Antibody: AST Clone #C2 (MBS2120702)

Matching Pairs

Cy3 Conjugated Antibody: AST Clone #C2 (MBS2120702)
Immunogen: AST (MBS2010613)

Molecular Weight

44,147 Da

OMIM

138180

3D Structure

ModBase 3D Structure for P17174

Supply Chain Verification

Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.

Immunogen Sequence

Met1~Gln413

Cross Reactivity

Human

Conjugation

Cy3

Product Categories/Family for anti-AST antibody

Enzyme & Kinase; Tumor Immunity; Infection Immunity; Hepatology

ISO Certification

Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.

Applications Tested/Suitable for anti-AST antibody

Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)

Other Notes

Small volumes of anti-AST antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for AST. It may not necessarily be applicable to this product.

NCBI GI #

4504067

NCBI GeneID

2805

NCBI Accession #

NP_002070.1

UniProt Primary Accession #

P17174

UniProt Secondary Accession #

Q5VW80; B2R6R7; B7Z7E9

UniProt Related Accession #

P17174

GenBank Nucleotide #

NM_002079.2

NCBI Official Full Name

aspartate aminotransferase, cytoplasmic

NCBI Official Synonym Full Names

glutamic-oxaloacetic transaminase 1, soluble

NCBI Official Symbol

GOT1

NCBI Official Synonym Symbols

cCAT; GIG18; cAspAT; ASTQTL1

UniProt Protein Name

Aspartate aminotransferase, cytoplasmic

UniProt Synonym Protein Names

Cysteine aminotransferase, cytoplasmic; Cysteine transaminase, cytoplasmic; cCAT; Glutamate oxaloacetate transaminase 1; Transaminase A

Protein Family

Allatostatin

UniProt Gene Name

GOT1

UniProt Synonym Gene Names

cAspAT; cCAT

UniProt Entry Name

AATC_HUMAN

NCBI Protein Information

aspartate aminotransferase, cytoplasmic; aspartate aminotransferase 1; aspartate transaminase 1; cysteine aminotransferase, cytoplasmic; cysteine transaminase, cytoplasmic; glutamate oxaloacetate transaminase 1; growth-inhibiting protein 18; transaminase

NCBI Summary for AST

Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. [provided by RefSeq, Jul 2008]

UniProt Comments for AST

GOT1: Plays a key role in amino acid metabolism. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

Protein type: Amino Acid Metabolism - cysteine and methionine; Transferase; Amino Acid Metabolism - phenylalanine, tyrosine and tryptophan biosynthesis; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - tyrosine; EC 2.6.1.1; Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - alanine, aspartate and glutamate; EC 2.6.1.3

Chromosomal Location of Human Ortholog: 10q24.1-q25.1

Cellular Component: lysosome; cytoplasm; nerve terminal; nucleus; cytosol

Molecular Function: cysteine transaminase activity; phosphatidylserine decarboxylase activity; carboxylic acid binding; aspartate transaminase activity; pyridoxal phosphate binding

Biological Process: glutamate metabolic process; oxaloacetate metabolic process; glutamate catabolic process to aspartate; response to glucocorticoid stimulus; glucose metabolic process; aspartate biosynthetic process; pathogenesis; gluconeogenesis; 2-oxoglutarate metabolic process; methionine salvage; cellular response to insulin stimulus; sulfur amino acid metabolic process; glycerol biosynthetic process; fatty acid homeostasis; carbohydrate metabolic process; aspartate catabolic process; aspartate metabolic process; amino acid biosynthetic process; glutamate catabolic process to 2-oxoglutarate; polyamine metabolic process

Disease: Aspartate Aminotransferase, Serum Level Of, Quantitative Trait Locus 1

Research Articles on AST

1. Alcohol consumption, smoking status, and metabolic syndrome impact on serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma-glutamyl transferase (GGT), was determined.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-AST antibody

Reference Product	PubMed Publications
GOT2 antibody	>7 publications with AST and GOT2
MDH1 antibody	>5 publications with AST and MDH1
LDHB antibody	>3 publications with AST and LDHB
MDH2 antibody	>2 publications with AST and MDH2

Pathways associated with anti-AST antibody

Products by Pathway	Pathway Diagram
2-Oxocarboxylic Acid Metabolism Pathway antibodies	2-Oxocarboxylic Acid Metabolism Pathway Diagram
2-Oxocarboxylic Acid Metabolism Pathway antibodies	2-Oxocarboxylic Acid Metabolism Pathway Diagram
Alanine And Aspartate Metabolism Pathway antibodies	Alanine And Aspartate Metabolism Pathway Diagram
Alanine, Aspartate And Glutamate Metabolism Pathway antibodies	Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
Alanine, Aspartate And Glutamate Metabolism Pathway antibodies	Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
Amino Acid Synthesis And Interconversion (transamination) Pathway antibodies	Amino Acid Synthesis And Interconversion (transamination) Pathway Diagram
Arginine And Proline Metabolism Pathway antibodies	Arginine And Proline Metabolism Pathway Diagram
Arginine And Proline Metabolism Pathway antibodies	Arginine And Proline Metabolism Pathway Diagram
Biosynthesis Of Amino Acids Pathway antibodies	Biosynthesis Of Amino Acids Pathway Diagram
Biosynthesis Of Amino Acids Pathway antibodies	Biosynthesis Of Amino Acids Pathway Diagram

Diseases associated with anti-AST antibody

Disease Name	Pubmed Publications
Disease Models, Animal Antibodies	>5 publications with AST and Disease Models, Animal
Nervous System Diseases Antibodies	>4 publications with AST and Nervous System Diseases
Lung Neoplasms Antibodies	>4 publications with AST and Lung Neoplasms
Breast Neoplasms Antibodies	>3 publications with AST and Breast Neoplasms
Cardiovascular Diseases Antibodies	>3 publications with AST and Cardiovascular Diseases
Liver Neoplasms Antibodies	>2 publications with AST and Liver Neoplasms
Liver Diseases Antibodies	>2 publications with AST and Liver Diseases
Fatty Liver Antibodies	>2 publications with AST and Fatty Liver
Fibrosis Antibodies	>2 publications with AST and Fibrosis
Weight Gain Antibodies	>1 publications with AST and Weight Gain

Organs/Tissues associated with anti-AST antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>15 publications with AST and Blood
Liver Antibodies	>7 publications with AST and Liver
Nerve Antibodies	>7 publications with AST and Nerve
Intestine Antibodies	>4 publications with AST and Intestine
Lung Antibodies	>4 publications with AST and Lung
Heart Antibodies	>4 publications with AST and Heart
Brain Antibodies	>4 publications with AST and Brain
Muscle Antibodies	>3 publications with AST and Muscle
Vascular Antibodies	>3 publications with AST and Vascular
Thyroid Antibodies	>2 publications with AST and Thyroid