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CD107b Antibody – Rat Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS212662

Rat anti Mouse CD107b antibody, clone M3/84 recognizes murine CD107b, also known as MAC-3 and LAMP-2. CD107b is a transmembrane glycoprotein that is associated with lysosomal membranes and is primarily expressed on mononuclear phagocytes. Expression of CD107b… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CD107b, Monoclonal Antibody
Full Product Name
RAT ANTI MOUSE CD107b
Product Gene Name
anti-CD107b antibody
Clonality
Monoclonal
Isotype
IgG1
Clone Number
M3/84
Host
Rat
Form/Format
Purified
Purified IgG - liquid
Concentration
IgG concentration 1.0 mg/ml (lot specific)
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Molecular Weight
45,655 Da
3D Structure
ModBase 3D Structure for P17047
Perservative Stabilisers
0.09% Sodium Azide
Preparation||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Target Species
Mouse
Applications Tested/Suitable for anti-CD107b antibody
Immunohistology Frozen, Flow cytometry (FC/FACS)*, Immunoprecipitation (IP), Immunohistology Paraffin, Western Blot (WB)
Application Notes for anti-CD107b antibody
Flow Cytometry: Use 10ul of the suggested working dilution to label 1x106 cells in 100ul.
Flow Cytometry: Minimum Dilution: 1/50; Maximum Dilution: 1/100; Application Note: Membrane permeabilisation is required for this application. MyBioSource recommends the use of Leucoperm for this purpose.

Testing Data of anti-CD107b antibody

Staining of mouse peritoneal macrophages with Rat anti Mouse CD107b : Alexa Fluor 488 (MBS212662A488). Permeabilised with Leucoperm
Rat Anti-CD107b Monoclonal Antibody – Cat# MBS212662

Testing Data of anti-CD107b antibody

Western blot analysis of CD107b on J774 cell lysate probed with Rat anti Mouse CD107b at 1/500, 1/1000, 1/2000. Rat anti tubulin alpha (MBS213160) is included as a loading control. Detection is with Goat anti Rat IgG:Dylight® (MBS224270)
Rat Anti-CD107b Monoclonal Antibody, Testing Data – Cat# MBS212662

Testing Data of anti-CD107b antibody

Staining of mouse peritoneal macrophages with Rat anti Mouse CD107b : FITC following permeabilisation with Leucoperm
Rat Anti-CD107b Monoclonal Antibody, Testing Data – Cat# MBS212662

Testing Data of anti-CD107b antibody

Staining of mouse peritoneal macrophages with Rat anti Mouse CD1076 following permeabilsation with Leucoperm
Rat Anti-CD107b Monoclonal Antibody, Testing Data – Cat# MBS212662

Testing Data of anti-CD107b antibody

Staining of mouse peritoneal macrophages with Rat anti MouseCD107b : Alexa Fluor 647 (MBS212662A647). Permeabilised with Leucoperm
Rat Anti-CD107b Monoclonal Antibody, Testing Data – Cat# MBS212662

Testing Data of anti-CD107b antibody

Staining of permeabilised mouse peritoneal macrophages with Rat anti Mouse CD107b: FITC (MBS210923)
Rat Anti-CD107b Monoclonal Antibody, Testing Data – Cat# MBS212662

Testing Data of anti-CD107b antibody

Staining of mouse peritoneal macrophages with Rat anti Mouse CD107b : Biotin (MBS210439). Permeabilised with Leucoperm
Rat Anti-CD107b Monoclonal Antibody, Testing Data – Cat# MBS212662

Other Notes

Small volumes of anti-CD107b antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD107b purchase

MBS212662 is an antibody targeting CD107b. Also known as RAT ANTI MOUSE CD107b. Host: Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for CD107b. It may not necessarily be applicable to this product.

NCBI GI #
63054837
NCBI GeneID
16784
NCBI Accession #
NP_001017959.1
UniProt Primary Accession #
P17047
UniProt Secondary Accession #
Q3TXG5; Q8BSG8; A2A430
UniProt Related Accession #
P17047
GenBank Nucleotide #
NM_001017959.2
NCBI Official Full Name
lysosome-associated membrane glycoprotein 2 isoform 1
NCBI Official Synonym Full Names
lysosomal-associated membrane protein 2
NCBI Official Symbol
Lamp2
NCBI Official Synonym Symbols
Mac3; LGP-B; CD107b; Lamp-2; Lamp II; Lamp-2a; Lamp-2b; Lamp-2c
UniProt Protein Name
Lysosome-associated membrane glycoprotein 2
UniProt Synonym Protein Names
CD107 antigen-like family member B; Lysosomal membrane glycoprotein type B; LGP-B; CD_antigen: CD107b
UniProt Gene Name
Lamp2
UniProt Synonym Gene Names
Lamp-2; LAMP-2; Lysosome-associated membrane protein 2; LGP-B
UniProt Entry Name
LAMP2_MOUSE
NCBI Protein Information
lysosome-associated membrane glycoprotein 2; CD107 antigen-like family member B; lysosomal membrane glycoprotein 2; lysosomal membrane glycoprotein type B

UniProt Comments for CD107b

LAMP2: Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens. Defects in LAMP2 are the cause of Danon disease (DAND); also known as glycogen storage disease type 2B (GSD2B). DAND is a lysosomal glycogen storage disease characterized by the clinical triad of cardiomyopathy, vacuolar myopathy and mental retardation. It is often associated with an accumulation of glycogen in muscle and lysosomes. Belongs to the LAMP family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Cellular Component: phagocytic vesicle membrane; membrane; lysosome; late endosome membrane; lysosomal membrane; late endosome; integral to membrane; plasma membrane; platelet dense granule membrane; endosome

Molecular Function: protein domain specific binding; enzyme binding

Biological Process: protein stabilization
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Research Articles on CD107b

1. deletion of the gene encoding LAMP-2A in T cells caused deficient in vivo responses to immunization or infection with Listeria monocytogenes.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD107b antibody

 Reference Product  PubMed Publications
 Rab7 antibody  >12 publications with CD107b and Rab7
 Eea1 antibody  >11 publications with CD107b and Eea1
 Cd63 antibody  >10 publications with CD107b and Cd63
 Ctsd antibody  >5 publications with CD107b and Ctsd
 Uchl1 antibody  >1 publications with CD107b and Uchl1
 Gba antibody  >1 publications with CD107b and Gba

Pathways associated with anti-CD107b antibody

 Products by Pathway  Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram
 Response To Elevated Platelet Cytosolic Ca2+ Pathway antibodies  Response To Elevated Platelet Cytosolic Ca2+ Pathway Diagram
 Senescence And Autophagy Pathway antibodies  Senescence And Autophagy Pathway Diagram
 Tuberculosis Pathway antibodies  Tuberculosis Pathway Diagram

Diseases associated with anti-CD107b antibody

 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >74 publications with CD107b and Heart Diseases
 Glycogen Storage Disease Type IIb Antibodies  >49 publications with CD107b and Glycogen Storage Disease Type IIb
 Hypertrophy Antibodies  >25 publications with CD107b and Hypertrophy
 Disease Models, Animal Antibodies  >17 publications with CD107b and Disease Models, Animal
 Inflammation Antibodies  >14 publications with CD107b and Inflammation
 Kidney Diseases Antibodies  >12 publications with CD107b and Kidney Diseases
 Congenital Abnormalities Antibodies  >9 publications with CD107b and Congenital Abnormalities
 Necrosis Antibodies  >9 publications with CD107b and Necrosis
 Liver Diseases Antibodies  >8 publications with CD107b and Liver Diseases
 Breast Neoplasms Antibodies  >5 publications with CD107b and Breast Neoplasms

Organs/Tissues associated with anti-CD107b antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >42 publications with CD107b and Brain
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