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CD321 Antibody – Rat Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS212721

Rat anti Mouse CD321 antibody, clone H202-106 recognizes murine CD321, which is also known as junctional adhesion molecule 1 (JAM-1). CD321 is a 32-41kD glycoprotein, which shares similarities with related proteins JAM-2 and JAM-3. CD321 is a multifunctional… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD321, Monoclonal Antibody
Full Product Name
RAT ANTI MOUSE CD321
Product Gene Name
anti-CD321 antibody
Clonality
Monoclonal
Isotype
IgG1
Clone Number
H202-106
Host
Rat
Form/Format
Purified
Purified IgG - liquid
Concentration
IgG concentration 1.0 mg/ml (lot specific)
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Molecular Weight
32,424 Da
3D Structure
ModBase 3D Structure for O88792
Perservative Stabilisers
0.09% Sodium Azide
Preparation||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Immunogen
MTE1/MTE2 stromal cell lines.
Fusion Partners||Cells from immunised Lou rats were fused with cells of the X63 mouse myeloma cell line.
Buffer Solution||Phosphate buffered saline
Target Species
Mouse
Applications Tested/Suitable for anti-CD321 antibody
Immunohistology Frozen, Flow cytometry (FC/FACS), Immunoprecipitation (IP)
Application Notes for anti-CD321 antibody
Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul.
Flow Cytometry: Minimum Dilution: 1/100; Maximum Dilution: 1/200

Testing Data of anti-CD321 antibody

Staining of mouse peripheral blood platelets with Rat anti Mouse CD321: Biotin (MBS210455)
Rat Anti-CD321 Monoclonal Antibody – Cat# MBS212721

Testing Data of anti-CD321 antibody

Staining of mouse peripheral blood platelets with Rat anti Mouse CD321 (MBS212720)
Rat Anti-CD321 Monoclonal Antibody, Testing Data – Cat# MBS212721

Testing Data of anti-CD321 antibody

Staining of mouse peripheral blood platelets with Rat anti Mouse CD321
Rat Anti-CD321 Monoclonal Antibody, Testing Data – Cat# MBS212721

Other Notes

Small volumes of anti-CD321 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD321 purchase

MBS212721 is an antibody targeting CD321. Also known as RAT ANTI MOUSE CD321. Host: Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for CD321. It may not necessarily be applicable to this product.

NCBI GI #
27734847
NCBI GeneID
16456
NCBI Accession #
NP_766235.1
UniProt Primary Accession #
O88792
UniProt Secondary Accession #
Q8VC39
UniProt Related Accession #
O88792
GenBank Nucleotide #
NM_172647.2
NCBI Official Full Name
junctional adhesion molecule A
NCBI Official Synonym Full Names
F11 receptor
NCBI Official Symbol
F11r
NCBI Official Synonym Symbols
JAM; Jcam; JAM-1; JAM-A; Jcam1; Ly106; ESTM33; AA638916; 9130004G24
UniProt Protein Name
Junctional adhesion molecule A
UniProt Synonym Protein Names
Junctional adhesion molecule 1; JAM-1; CD_antigen: CD321
Protein Family
Junctional adhesion molecule
UniProt Gene Name
F11r
UniProt Synonym Gene Names
Jam1; Jcam; Jcam1; JAM-A; JAM-1
UniProt Entry Name
JAM1_MOUSE
NCBI Protein Information
junctional adhesion molecule A; BV11 antigen; F11 receptor/F11R; junction cell adhesion molecule A; junction cell adhesion molecule1; junctional adhesion molecule 1

UniProt Comments for CD321

JAM-A: Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus. Belongs to the immunoglobulin superfamily.

Protein type: Cell adhesion; Membrane protein, integral

Cellular Component: microtubule cytoskeleton; tight junction; membrane; integral to membrane; plasma membrane; cytoplasmic vesicle; intercellular junction; cell junction

Molecular Function: protein binding; PDZ domain binding

Biological Process: epithelial cell differentiation; viral reproduction; actomyosin structure organization and biogenesis; cell adhesion; positive regulation of blood pressure; intestinal absorption
Show more

Research Articles on CD321

1. The F11r gene is directly regulated by retinoic acid in the embryonic mesoderm.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD321 antibody

 Reference Product  PubMed Publications
 Tjp1 antibody  >24 publications with CD321 and Tjp1
 Itgb2 antibody  >2 publications with CD321 and Itgb2
 Mllt4 antibody  >2 publications with CD321 and Mllt4
 Pard6a antibody  >1 publications with CD321 and Pard6a
 Mpdz antibody  >1 publications with CD321 and Mpdz

Pathways associated with anti-CD321 antibody

 Products by Pathway  Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Junction Organization Pathway antibodies  Cell Junction Organization Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 Cell-cell Junction Organization Pathway antibodies  Cell-cell Junction Organization Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Integrin Cell Surface Interactions Pathway antibodies  Integrin Cell Surface Interactions Pathway Diagram

Diseases associated with anti-CD321 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >28 publications with CD321 and Inflammation
 Necrosis Antibodies  >13 publications with CD321 and Necrosis
 Breast Neoplasms Antibodies  >12 publications with CD321 and Breast Neoplasms
 Atherosclerosis Antibodies  >11 publications with CD321 and Atherosclerosis
 Disease Models, Animal Antibodies  >11 publications with CD321 and Disease Models, Animal
 Neoplasm Metastasis Antibodies  >8 publications with CD321 and Neoplasm Metastasis
 Heart Diseases Antibodies  >6 publications with CD321 and Heart Diseases
 Neoplasm Invasiveness Antibodies  >6 publications with CD321 and Neoplasm Invasiveness
 Lung Neoplasms Antibodies  >4 publications with CD321 and Lung Neoplasms
 Kidney Diseases Antibodies  >4 publications with CD321 and Kidney Diseases

Organs/Tissues associated with anti-CD321 antibody

 Organ/Tissue Name  Pubmed Publications
 Intestine Antibodies  >16 publications with CD321 and Intestine
 Brain Antibodies  >14 publications with CD321 and Brain
 Heart Antibodies  >14 publications with CD321 and Heart
 Lung Antibodies  >13 publications with CD321 and Lung
 Liver Antibodies  >12 publications with CD321 and Liver
 Muscle Antibodies  >10 publications with CD321 and Muscle
 Kidney Antibodies  >9 publications with CD321 and Kidney
 Embryonic Tissue Antibodies  >9 publications with CD321 and Embryonic Tissue
 Eye Antibodies  >6 publications with CD321 and Eye
 Skin Antibodies  >5 publications with CD321 and Skin
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