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C1Q Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS214405

Mouse anti human C1q antibody, clone 3R9/2, recognizes human complement component 1 q (C1q), a 156kDa secreted protein. C1q associates with proenzymes C1r and C1s to form the calcium-dependent C1 complex, the first component of the serum complement system.… More details

$760 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
C1q, Monoclonal Antibody
Full Product Name
MOUSE ANTI HUMAN C1q
Product Gene Name
Product Synonym Names
COMPLEMENT COMPONENT 1q; C1QG
Clonality
Monoclonal
Isotype
IgG1
Clone Number
3R9/2
Host
Mouse
Form/Format
Purified IgG - liquid
Concentration
Approximate Protein Concentration: 1.0 mg/ml (lot specific)
Specificity
C1q
Preparation and Storage
Store at 4°C or at -20°C if preferred. Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from the date of despatch.
Molecular Weight
26,017 Da
OMIM
120550
Immunogen
Globular head domain of C1q, purified from human plasma
Perservative Stabilisers
0.09% Sodium Azide (NaN3)
Preparation
Purified IgG prepared by affinity chromatography on Protein A
Histology Positive Control Tissue
Kidney from patients with streptococcal glomerulonephritis.
Buffer Solution
Borate buffered saline
Target Species
Human
Applications Tested/Suitable for anti-C1q antibody
Immunohistology Frozen, ELISA (EIA), Flow cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB)
Application Notes for anti-C1q antibody
Immunohistology - Frozen: 1:500-1:1000
Immunohistology: For best results MyBioSource recommends HISTAR detection kits.

Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

Other Notes

Small volumes of anti-C1q antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for C1q purchase

MBS214405 is an antibody targeting C1q. Also known as MOUSE ANTI HUMAN C1q. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for C1q. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
complement C1q subcomponent subunit A
NCBI Official Synonym Full Names
complement component 1, q subcomponent, A chain
NCBI Official Symbol
C1QA
UniProt Protein Name
Complement C1q subcomponent subunit A
Protein Family
UniProt Gene Name
C1QA
UniProt Entry Name
C1QA_HUMAN
NCBI Protein Information
complement C1q subcomponent subunit A; complement component 1, q subcomponent, alpha polypeptide; complement component C1q, A chain

NCBI Summary for C1q

This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the A-chain polypeptide of human complement subcomponent C1q. [provided by RefSeq, Jul 2008]
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UniProt Comments for C1q

C1QA iso2: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2 )-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1p36.12

Cellular Component: collagen; extracellular region; complement component C1 complex

Molecular Function: protein binding

Biological Process: cell-cell signaling; innate immune response; complement activation, classical pathway; complement activation

Disease: C1q Deficiency
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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