Mouse Anti-PYGL Monoclonal Antibody – Cat# MBS2165779

Glycogen Phosphorylase, Liver (PYGL) Antibody – Mouse Monoclonal

Name: PYGL Antibody; Monoclonal; Mouse; Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS2165779
Price: 345 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2165779

MBS2165779 is an antibody targeting PYGL. Also known as APC-Linked Monoclonal Antibody to Glycogen Phosphorylase, Liver (PYGL). Reactive in Rat. Host: Mouse. More details

$345 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Glycogen Phosphorylase, Liver (PYGL), Monoclonal Antibody

Full Product Name

APC-Linked Monoclonal Antibody to Glycogen Phosphorylase, Liver (PYGL)

Product Gene Name

anti-PYGL antibody

Product Synonym Names

Glycogen Phosphorylase, Liver; GPLL; GPBB; Hers Disease; Glycogen Storage Disease Type VI

Immunogen Sequence

Gln73~Val2 67

Clonality

Monoclonal

Clone Number

15#

Host

Mouse

Species Reactivity

Rat

Form/Format

Liquid; 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.

Purity/Purification

Protein A + Protein G affinity chromatography

Concentration

>=0.1mg/mL (Please refer to the vial label for the specific concentration.) (lot specific)

Preparation and Storage

Store at 2 degree C to 8 degree C for frequent use, -20 degree C for 12 months

Matching Pairs

APC Conjugated Antibody: PYGL Clone #15# (MBS2165779)
Immunogen: PYGL (MBS2011796)

Matching Pairs

Unconjugated Antibody: PYGL Clone #15# (MBS2170105)
APC Conjugated Antibody: PYGL Clone #15# (MBS2165779)

Molecular Weight

97,483 Da

3D Structure

ModBase 3D Structure for P09811

Supply Chain Verification

Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.

Conjugation

APC

Product Categories/Family for anti-PYGL antibody

Monoclonal Antibodies (Primary Abs); Primary, APC-conjugated; Enzyme & Kinase; Metabolic pathway; Endocrinology

ISO Certification

Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.

Applications Tested/Suitable for anti-PYGL antibody

Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)

Application Notes for anti-PYGL antibody

WB: 0.2-2ug/mL
IHC: 5-20ug/mL
ICC: 5-20ug/mL

Other Notes

Small volumes of anti-PYGL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PYGL. It may not necessarily be applicable to this product.

NCBI GI #

11560087

NCBI GeneID

64035

NCBI Accession #

NP_071604.1

UniProt Primary Accession #

P09811

UniProt Related Accession #

P09811

GenBank Nucleotide #

NM_022268.1

NCBI Official Full Name

glycogen phosphorylase, liver form

NCBI Official Synonym Full Names

glycogen phosphorylase L

NCBI Official Symbol

Pygl

UniProt Protein Name

Glycogen phosphorylase, liver form

Protein Family

Glycogen phosphorylase

UniProt Gene Name

Pygl

UniProt Synonym Gene Names

Lgp

NCBI Protein Information

glycogen phosphorylase, liver form

NCBI Summary for PYGL

catalyzes the rate-limiting step of glycogen catabolism [RGD, Feb 2006]

UniProt Comments for PYGL

PYGL: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. Defects in PYGL are the cause of glycogen storage disease type 6 (GSD6). A metabolic disorder characterized by mild to moderate hypoglycemia, mild ketosis, growth retardation, and prominent hepatomegaly. Heart and skeletal muscle are not affected. Belongs to the glycogen phosphorylase family.

Protein type: Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.1; Transferase

Chromosomal Location of Human Ortholog: 6q24

Cellular Component: cytoplasm

Molecular Function: AMP binding; ATP binding; bile acid binding; carbohydrate binding; drug binding; glycogen phosphorylase activity; protein homodimerization activity; purine binding; pyridoxal phosphate binding; vitamin binding

Biological Process: 5-phosphoribose 1-diphosphate biosynthetic process; glucose homeostasis; glycogen catabolic process; glycogen metabolic process

Research Articles on PYGL

1. Data show that two biomarkers, glycine N-methyltransferase (GNMT) and glycogen phosphorylase (PYGL), were found to indicate early hepatic injuries.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PYGL antibody

Reference Product	PubMed Publications
Phkb antibody	>3 publications with PYGL and Phkb
Gys1 antibody	>3 publications with PYGL and Gys1
Gys2 antibody	>1 publications with PYGL and Gys2
Pgm1 antibody	>1 publications with PYGL and Pgm1
Agl antibody	>1 publications with PYGL and Agl

Pathways associated with anti-PYGL antibody

Products by Pathway	Pathway Diagram
Glucagon Signaling Pathway antibodies	Glucagon Signaling Pathway Diagram
Glucagon Signaling Pathway antibodies	Glucagon Signaling Pathway Diagram
Glucose Metabolism Pathway antibodies	Glucose Metabolism Pathway Diagram
Glycogen Metabolism Pathway antibodies	Glycogen Metabolism Pathway Diagram
Glycogen Breakdown (glycogenolysis) Pathway antibodies	Glycogen Breakdown (glycogenolysis) Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram
Insulin Resistance Pathway antibodies	Insulin Resistance Pathway Diagram
Insulin Signaling Pathway antibodies	Insulin Signaling Pathway Diagram
Insulin Signaling Pathway antibodies	Insulin Signaling Pathway Diagram

Diseases associated with anti-PYGL antibody

Disease Name	Pubmed Publications
Glycogen Storage Disease Type VI Antibodies	>6 publications with PYGL and Glycogen Storage Disease Type VI
Hepatomegaly Antibodies	>5 publications with PYGL and Hepatomegaly
Liver Diseases Antibodies	>5 publications with PYGL and Liver Diseases
Drug-Related Side Effects and Adverse Reactions Antibodies	>1 publications with PYGL and Drug-Related Side Effects and Adverse Reactions
Weight Gain Antibodies	>1 publications with PYGL and Weight Gain
Hypertrophy Antibodies	>1 publications with PYGL and Hypertrophy
Fibrosis Antibodies	>1 publications with PYGL and Fibrosis
Fatty Liver Antibodies	>1 publications with PYGL and Fatty Liver
Drug-Induced Liver Injury Antibodies	>1 publications with PYGL and Drug-Induced Liver Injury
Poisoning Antibodies	>1 publications with PYGL and Poisoning

Organs/Tissues associated with anti-PYGL antibody

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>15 publications with PYGL and Liver
Heart Antibodies	>2 publications with PYGL and Heart
Ovary Antibodies	>1 publications with PYGL and Ovary