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Il-7 (IL7) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS221267

Rabbit anti Mouse Interleukin-7 antibody recognizes mouse interleukin-7 (IL-7). The biological activity of IL-7 includes stimulating the proliferation of pre-B cells, pro-B cells and activated T cells and inducing the synthesis of other inflammatory… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
IL-7 (Il7), Polyclonal Antibody
Full Product Name
RABBIT ANTI MOUSE INTERLEUKIN-7
Product Gene Name
anti-Il7 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Form/Format
Purified
Purified IgG - lyophilised
Concentration
IgG concentration 1.0 mg/ml (lot specific)
Preparation and Storage
Prior to reconstitution store at 4 degree C. Following reconstitution store at -20 degree C. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. For long term storage, the addition of 0. 09% sodium azide is recommended. N. B. For functional studies do not add azide.
Shelf Life: 12 months from date of reconstitution.
Molecular Weight
17,727 Da
3D Structure
ModBase 3D Structure for P10168
Reconstitution
Reconstitute with 0.1 ml distilled water. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. MyBioSource recommends that the vial is gently mixed after reconstitution.
Immunogen
Recombinant mouse IL-7
Buffer Solution||Phosphate buffered saline
Antiserum Preparation
Antisera to mouse IL-7 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Target Species
Mouse
Applications Tested/Suitable for anti-Il7 antibody
ELISA (EIA), Functional Assays (FN), Western Blot (WB)
Application Notes for anti-Il7 antibody
ELISA: Maximum Dilution: 0.5ug/ml;
Functional Assays: Minimum Dilution: 0.08ug/ml; Maximum Dilution: 0.1ug/ml;
Western Blotting: Minimum Dilution: 0.1ug/ml; Maximum Dilution: 0.2ug/ml

Other Notes

Small volumes of anti-Il7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Il7 purchase

MBS221267 is an antibody targeting Il7. Also known as RABBIT ANTI MOUSE INTERLEUKIN-7. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Il7. It may not necessarily be applicable to this product.

NCBI GI #
6680433
NCBI GeneID
16196
NCBI Accession #
NP_032397.1
UniProt Primary Accession #
P10168
UniProt Related Accession #
P10168
GenBank Nucleotide #
NM_008371.4
NCBI Official Full Name
interleukin-7
NCBI Official Synonym Full Names
interleukin 7
NCBI Official Symbol
Il7
NCBI Official Synonym Symbols
Il-7; hlb368; A630026I06Rik
UniProt Protein Name
Interleukin-7
Protein Family
Interleukin
UniProt Gene Name
Il7
UniProt Synonym Gene Names
Il-7; IL-7
UniProt Entry Name
IL7_MOUSE
NCBI Protein Information
interleukin-7

NCBI Summary for Il7

The protein encoded by this gene is a hematopoietic growth factor important for B and T cell development. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]

UniProt Comments for Il7

IL7: Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine; Cell cycle regulation; Secreted; Apoptosis; Secreted, signal peptide; Cell development/differentiation

Cellular Component: extracellular space; extracellular region

Molecular Function: interleukin-7 receptor binding; growth factor activity; hematopoietin/interferon-class (D200-domain) cytokine receptor binding; cytokine activity

Biological Process: organ morphogenesis; T cell lineage commitment; cell-cell signaling; positive regulation of T cell differentiation; homeostasis of number of cells within a tissue; regulation of gene expression; negative regulation of catalytic activity; positive regulation of B cell proliferation; immune response; positive regulation of organ growth; humoral immune response; bone resorption
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Research Articles on Il7

1. OX40 and IL-7 play synergistic, but distinct roles in the homeostatic proliferation of CD4(+) effector memory T cells

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Il7 antibody

 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokines And Inflammatory Response (BioCarta) Pathway antibodies  Cytokines And Inflammatory Response (BioCarta) Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interleukin-7 Signaling Pathway antibodies  Interleukin-7 Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram

Diseases associated with anti-Il7 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >27 publications with Il7 and Inflammation
 Necrosis Antibodies  >21 publications with Il7 and Necrosis
 Multiple Sclerosis Antibodies  >19 publications with Il7 and Multiple Sclerosis
 Lymphopenia Antibodies  >17 publications with Il7 and Lymphopenia
 Neoplasms, Experimental Antibodies  >15 publications with Il7 and Neoplasms, Experimental
 Death Antibodies  >14 publications with Il7 and Death
 Carcinoma Antibodies  >11 publications with Il7 and Carcinoma
 Cell Transformation, Neoplastic Antibodies  >7 publications with Il7 and Cell Transformation, Neoplastic
 Sepsis Antibodies  >6 publications with Il7 and Sepsis
 Hypersensitivity Antibodies  >6 publications with Il7 and Hypersensitivity

Organs/Tissues associated with anti-Il7 antibody

 Organ/Tissue Name  Pubmed Publications
 Other Antibodies  >42 publications with Il7 and Other
 Thymus Antibodies  >40 publications with Il7 and Thymus
 Spleen Antibodies  >12 publications with Il7 and Spleen
 Lung Antibodies  >10 publications with Il7 and Lung
 Liver Antibodies  >10 publications with Il7 and Liver
 Embryonic Tissue Antibodies  >4 publications with Il7 and Embryonic Tissue
 Ovary Antibodies  >3 publications with Il7 and Ovary
 Mammary Gland Antibodies  >2 publications with Il7 and Mammary Gland
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