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TACR3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS222943

MBS222943 recognises human TACR3 otherwise known as NK3 Receptor (NK3R), a 52.2 kDa multi-pass membrane protein belonging to the G-protein coupled receptor 1 family. TACR3 is a receptor for the tachykinin neuropeptide, neuromedin-k otherwise known as… More details

$670 / 0.1 mg +1 FREE 8GB USB
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Testing Data View PDF
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Product Overview

Online Datasheet in PDF
Product Name
TACR3, Polyclonal Antibody
Full Product Name
RABBIT ANTI TACR3
Product Gene Name
anti-TACR3 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse
Form/Format
Purified
Purified IgG - liquid
Concentration
IgG concentration 1.0mg/ml (lot specific)
Specificity
This item recognises human TACR3 otherwise known as NK3 Receptor (NK3R), a 52.2 kDa multi-pass membrane protein belonging to the G-protein coupled receptor 1 family.

TACR3 is a receptor for the tachykinin neuropeptide, neuromedin-k otherwise known as neurokinin B and is highly expressed in the supraoptic and paraventricular nuclei. Following binding of its ligand, NK3R activates a phosphatidylinositol-calcium second messenger system, and it is likely that these signals lead to the release of vasopressin and oxytocin into the circulation. Studies with mice indicate that TACR3 is involved in learning and memory.

This item does not recognise NK1R or NK2R.
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Molecular Weight
52,202 Da
OMIM
162332
3D Structure
ModBase 3D Structure for P29371
Perservative Stabilisers
0.02% Sodium Azide (NaN3)
Immunogen
An 18 amino acid peptide from near the centre of human TACR3.
Histology Positive Control Tissue||Human brain
Buffer Solution||Phosphate buffered saline
Antiserum Preparation
Antiserum to human TACR3 was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Target Species
Human
Applications Tested/Suitable for anti-TACR3 antibody
Immunohistology Paraffin*, Western Blot (WB)
Application Notes for anti-TACR3 antibody
Western Blot: This item detects a band of approximately 46kDa in RAW264.7 cell lysates.
Immunohistology - Paraffin: Maximum Dilution: 5ug/ml; Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.
Western Blotting: Minimum Dilution: 0.5; Maximum Dilution: 1.0ug/ml

Testing Data #1 of anti-TACR3 antibody

Western blot analysis of whole cell lysate from RAW264.7 mouse macrophage cells probed with Rabbit anti Human TACR3 (MBS222943) at 0.5(A) and 2(B) ug/ml
Rabbit Anti-TACR3 Polyclonal Antibody – Cat# MBS222943

Testing Data #2 of anti-TACR3 antibody

Formalin fixed, paraffin embedded human brain with Rabbit anti Human TACR3 (MBS222943) following heat mediated antigen retrieval using sodium citrate buffer (pH6.0)
Rabbit Anti-TACR3 Polyclonal Antibody, Testing Data #2 – Cat# MBS222943

Other Notes

Small volumes of anti-TACR3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TACR3 purchase

MBS222943 is an antibody targeting TACR3. Also known as RABBIT ANTI TACR3. Reactive in Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TACR3. It may not necessarily be applicable to this product.

NCBI GI #
7669548
NCBI GeneID
6870
NCBI Accession #
NP_001050.1
UniProt Primary Accession #
P29371
UniProt Secondary Accession #
Q0P510
UniProt Related Accession #
P29371
GenBank Nucleotide #
NM_001059.2
NCBI Official Full Name
neuromedin-K receptor
NCBI Official Synonym Full Names
tachykinin receptor 3
NCBI Official Symbol
TACR3
NCBI Official Synonym Symbols
NKR; HH11; NK3R; NK-3R; TAC3RL
UniProt Protein Name
Neuromedin-K receptor
UniProt Synonym Protein Names
NK-3 receptor; NK-3R; Neurokinin B receptor; Tachykinin receptor 3
Protein Family
Neuromedin-K receptor
UniProt Gene Name
TACR3
UniProt Synonym Gene Names
NK3R; TAC3R; NKR; NK-3R
UniProt Entry Name
NK3R_HUMAN
NCBI Protein Information
neuromedin-K receptor; NK-3 receptor; neurokinin B receptor; neurokinin beta receptor

NCBI Summary for TACR3

This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B. [provided by RefSeq, Jul 2008]
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UniProt Comments for TACR3

TACR3: This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: 4q25

Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane; nucleus

Molecular Function: protein binding; tachykinin receptor activity

Biological Process: tachykinin signaling pathway; hyperosmotic salinity response; regulation of dopamine metabolic process; response to morphine; positive regulation of heart rate; response to cocaine; positive regulation of blood pressure; response to estradiol stimulus; aging

Disease: Hypogonadotropic Hypogonadism 11 With Or Without Anosmia
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Research Articles on TACR3

1. data indicate that GPR54 and TACR3 gene mutations are not a frequent cause of ICPP. The identified A/G synonymous SNP (dbSNP ID: rs10407968) located in exon 1 of the gene is not likely to have a pathogenic role in exon splicing

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TACR3 antibody

 Reference Product  PubMed Publications
 TAC3 antibody  >39 publications with TACR3 and TAC3
 KISS1R antibody  >20 publications with TACR3 and KISS1R
 KISS1 antibody  >16 publications with TACR3 and KISS1
 PROK2 antibody  >15 publications with TACR3 and PROK2
 GNRH1 antibody  >11 publications with TACR3 and GNRH1
 TAC1 antibody  >6 publications with TACR3 and TAC1

Pathways associated with anti-TACR3 antibody

 Products by Pathway  Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies  Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram

Diseases associated with anti-TACR3 antibody

 Disease Name  Pubmed Publications
 Hypogonadism Antibodies  >35 publications with TACR3 and Hypogonadism
 Idiopathic Hypogonadotropic Hypogonadism Antibodies  >10 publications with TACR3 and Idiopathic Hypogonadotropic Hypogonadism
 Disorders of Sex Development Antibodies  >9 publications with TACR3 and Disorders of Sex Development
 Genital Diseases, Male Antibodies  >2 publications with TACR3 and Genital Diseases, Male
 Hypertension Antibodies  >2 publications with TACR3 and Hypertension
 Cocaine-Related Disorders Antibodies  >2 publications with TACR3 and Cocaine-Related Disorders
 Brain Diseases Antibodies  >1 publications with TACR3 and Brain Diseases
 Memory Disorders Antibodies  >1 publications with TACR3 and Memory Disorders
 Learning Disorders Antibodies  >1 publications with TACR3 and Learning Disorders
 Cognition Disorders Antibodies  >1 publications with TACR3 and Cognition Disorders

Organs/Tissues associated with anti-TACR3 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >1 publications with TACR3 and Muscle
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