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ADIPOR2 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS224022

Goat anti Human AdipoR2 antibody recognizes an epitope within the N-terminal (NT) region of Adiponectin Receptor protein 2 (AdipoR2), a transmembrane protein and member of the ADIPOR family, expressed mainly in the liver and skeletal muscle, which acts a… More details

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Product Overview

Product Name
ADIPOR2, Polyclonal Antibody
Full Product Name
GOAT ANTI HUMAN ADIPOR2 (N-TERMINAL)
Product Gene Name
anti-ADIPOR2 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Goat
Species Reactivity
Mouse (Expected from Sequence), Rat (Expected from Sequence)
Form/Format
Purified
Purified IgG - liquid
Concentration
IgG concentration 1.0 mg/ml (lot specific)
Preparation and Storage
Store at -20 degree C only. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Molecular Weight
43,884 Da
OMIM
607946
3D Structure
ModBase 3D Structure for Q86V24
Perservative Stabilisers
0.1% Sodium Azide (NaN3)
0.1% Bovine Serum Albumin
Histology Positive Control Tissue
Liver and muscle
Buffer Solution||Phosphate buffered saline
Antiserum Preparation
Antiserum to human AdipoR2 (NT) was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.
Target Species
Human
Applications Tested/Suitable for anti-ADIPOR2 antibody
Immunohistology Paraffin, Western Blot (WB)
Application Notes for anti-ADIPOR2 antibody
Immunohistology - Paraffin: Minimum Dilution: 1/250;
Western Blotting: Minimum Dilution: 1/1000

Testing Data #1 of anti-ADIPOR2 antibody

Paraffin embedded human liver stained with Goat anti human AdipoR2 (MBS224022)
Goat Anti-ADIPOR2 Polyclonal Antibody – Cat# MBS224022

Testing Data #2 of anti-ADIPOR2 antibody

Paraffin embedded human muscle stained with Goat anti human AdipoR2 (MBS224022)
Goat Anti-ADIPOR2 Polyclonal Antibody, Testing Data #2 – Cat# MBS224022

Other Notes

Small volumes of anti-ADIPOR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ADIPOR2 purchase

MBS224022 is an antibody targeting ADIPOR2. Also known as GOAT ANTI HUMAN ADIPOR2 (N-TERMINAL). Reactive in Mouse (Expected from Sequence), Rat (Expected from Sequence). Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for ADIPOR2. It may not necessarily be applicable to this product.

NCBI GI #
38261973
NCBI GeneID
79602
NCBI Accession #
NP_078827.2
UniProt Primary Accession #
Q86V24
UniProt Secondary Accession #
Q53YY5; Q9H737
UniProt Related Accession #
Q86V24
GenBank Nucleotide #
NM_024551.2
NCBI Official Full Name
adiponectin receptor protein 2
NCBI Official Synonym Full Names
adiponectin receptor 2
NCBI Official Symbol
ADIPOR2
NCBI Official Synonym Symbols
PAQR2; ACDCR2
UniProt Protein Name
Adiponectin receptor protein 2
UniProt Synonym Protein Names
Progestin and adipoQ receptor family member II
Protein Family
Adiponectin receptor protein
UniProt Gene Name
ADIPOR2
UniProt Synonym Gene Names
PAQR2
UniProt Entry Name
ADR2_HUMAN
NCBI Protein Information
adiponectin receptor protein 2; progestin and adipoQ receptor family member II

NCBI Summary for ADIPOR2

The adiponectin receptors, ADIPOR1 (MIM 607945) and ADIPOR2, serve as receptors for globular and full-length adiponectin (MIM 605441) and mediate increased AMPK (see MIM 602739) and PPAR-alpha (PPARA; MIM 170998) ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin (Yamauchi et al., 2003 [PubMed 12802337]).[supplied by OMIM, Mar 2008]
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UniProt Comments for ADIPOR2

ADIPOR2: Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some intermediate-affinity receptor activity for both globular and full-length adiponectin. Belongs to the ADIPOR family.

Protein type: Membrane protein, multi-pass; Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p13.31

Cellular Component: integral to membrane; plasma membrane

Molecular Function: adiponectin binding; identical protein binding; hormone binding; protein heterodimerization activity; receptor activity

Biological Process: positive regulation of glucose import; hormone-mediated signaling; heart development; adiponectin-mediated signaling pathway; fatty acid oxidation; female pregnancy; negative regulation of cell growth; response to nutrient
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Research Articles on ADIPOR2

1. AdipoR1 stimulates IL10 production by activating the AMPK and MAPKp38 pathways, whereas AdipoR2 modifies inflammatory processes by activating the COX-2 and PPARG pathways.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ADIPOR2 antibody

 Reference Product  PubMed Publications
 ADIPOQ antibody  >101 publications with ADIPOR2 and ADIPOQ
 PPARG antibody  >25 publications with ADIPOR2 and PPARG
 APPL1 antibody  >21 publications with ADIPOR2 and APPL1
 STAT3 antibody  >10 publications with ADIPOR2 and STAT3
 LEP antibody  >5 publications with ADIPOR2 and LEP
 STK11 antibody  >2 publications with ADIPOR2 and STK11
 PPARA antibody  >2 publications with ADIPOR2 and PPARA

Pathways associated with anti-ADIPOR2 antibody

 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Non-alcoholic Fatty Liver Disease (NAFLD) Pathway antibodies  Non-alcoholic Fatty Liver Disease (NAFLD) Pathway Diagram
 Non-alcoholic Fatty Liver Disease (NAFLD) Pathway antibodies  Non-alcoholic Fatty Liver Disease (NAFLD) Pathway Diagram

Diseases associated with anti-ADIPOR2 antibody

 Disease Name  Pubmed Publications
 Insulin Resistance Antibodies  >162 publications with ADIPOR2 and Insulin Resistance
 Fatty Liver Antibodies  >80 publications with ADIPOR2 and Fatty Liver
 Inflammation Antibodies  >68 publications with ADIPOR2 and Inflammation
 Liver Diseases Antibodies  >59 publications with ADIPOR2 and Liver Diseases
 Cardiovascular Diseases Antibodies  >45 publications with ADIPOR2 and Cardiovascular Diseases
 Necrosis Antibodies  >39 publications with ADIPOR2 and Necrosis
 Disease Models, Animal Antibodies  >34 publications with ADIPOR2 and Disease Models, Animal
 Atherosclerosis Antibodies  >34 publications with ADIPOR2 and Atherosclerosis
 Hyperglycemia Antibodies  >24 publications with ADIPOR2 and Hyperglycemia
 Heart Diseases Antibodies  >22 publications with ADIPOR2 and Heart Diseases

Organs/Tissues associated with anti-ADIPOR2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >190 publications with ADIPOR2 and Blood
 Adipose Tissue Antibodies  >174 publications with ADIPOR2 and Adipose Tissue
 Liver Antibodies  >145 publications with ADIPOR2 and Liver
 Muscle Antibodies  >132 publications with ADIPOR2 and Muscle
 Connective Tissue Antibodies  >89 publications with ADIPOR2 and Connective Tissue
 Heart Antibodies  >45 publications with ADIPOR2 and Heart
 Brain Antibodies  >36 publications with ADIPOR2 and Brain
 Ovary Antibodies  >26 publications with ADIPOR2 and Ovary
 Kidney Antibodies  >17 publications with ADIPOR2 and Kidney
 Placenta Antibodies  >16 publications with ADIPOR2 and Placenta
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