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Thioredoxin Reductase 2 (TXNRD2) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS224808

Mouse anti thioredoxin reductase 2, clone 7B2, recognizes thioredoxin reductase 2 also known as selenoprotein Z. Thioredoxin reductase 2 is a member of the thioredoxin reductase family. They are a family of seleno-cysteine containing pyridine… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
THIOREDOXIN REDUCTASE 2 (TXNRD2), Monoclonal Antibody
Full Product Name
MOUSE ANTI THIOREDOXIN REDUCTASE 2
Product Gene Name
Clonality
Monoclonal
Isotype
IgG1
Clone Number
7B2
Host
Mouse
Species Reactivity
Human
Form/Format
Purified IgG - liquid
Concentration
IgG concentration 1.0 mg/ml (lot specific)
Specificity
THIOREDOXIN REDUCTASE 2
Preparation and Storage
Store at -20 degree C only. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 12 months from date of despatch
Molecular Weight
30,291 Da
OMIM
606448
3D Structure
ModBase 3D Structure for Q9NNW7
Preparation
IgG fraction prepared by ammonium sulphate precipitation
Preservative Stabilisers
0.03% Sodium Azide (NaN3), 0.01% Bovine Serum Albumin, 50% Glycerol
Buffer Solution
HEPES buffered saline
Applications Tested/Suitable for anti-TXNRD2 antibody
Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-TXNRD2 antibody
Immunoprecipitation: 1.0; 2.0 ul
Western Blot: 1/1000

Western Blot (WB) of anti-TXNRD2 antibody

Western blot analysis of mouse anti thioredoxin reductase 2 antibody with cell lysates. Lane 1; input, lane 2: precipitated sample
Mouse Anti-TXNRD2 Monoclonal Antibody – Cat# MBS224808

Other Notes

Small volumes of anti-TXNRD2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TXNRD2 purchase

MBS224808 is an antibody targeting TXNRD2. Also known as MOUSE ANTI THIOREDOXIN REDUCTASE 2. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for TXNRD2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Thioredoxin reductase 2, mitochondrial
NCBI Official Synonym Full Names
thioredoxin reductase 2
NCBI Official Symbol
TXNRD2
NCBI Official Synonym Symbols
TR; TR3; SELZ; TRXR2; TR-BETA
UniProt Protein Name
Thioredoxin reductase 2, mitochondrial
UniProt Synonym Protein Names
Selenoprotein Z; SelZ; TR-beta; Thioredoxin reductase TR3
Protein Family
UniProt Gene Name
TXNRD2
UniProt Synonym Gene Names
KIAA1652; TRXR2; SelZ
UniProt Entry Name
TRXR2_HUMAN
NCBI Protein Information
thioredoxin reductase 2, mitochondrial

NCBI Summary for TXNRD2

This gene encodes a member of the class I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein is a selenocysteine-containing flavoenzyme that maintains thioredoxins in a reduced state, thereby playing a key role in regulating the cellular redox environment. Mammals have three related thioredoxin reductases. This gene encodes a mitochondrial form important for scavenging of reactive oxygen species in mitochondria. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2013]
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UniProt Comments for TXNRD2

TXNRD2: Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox- regulated cell signaling. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator; Nucleotide Metabolism - pyrimidine; EC 1.8.1.9; Oxidoreductase

Chromosomal Location of Human Ortholog: 22q11.21

Cellular Component: mitochondrial matrix; mitochondrion

Molecular Function: FAD binding; protein binding; thioredoxin-disulfide reductase activity

Biological Process: cell redox homeostasis; response to oxygen radical; response to reactive oxygen species
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TXNRD2 antibody

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