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Presenilin-2 (PSEN2) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS225154

Rabbit anti presenilin-2 antibody recognizes presenilin-2. Presenilin-2 forms part of the gamma secratase complex responsible for the production of beta amyloid peptides. Presenilin-2 also modulates endoplasmic reticulum-mitochondria tethering. More details

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Product Overview

Product Name
Presenilin-2 (PSEN2), Polyclonal Antibody
Full Product Name
Rabbit anti Presenilin-2
Product Gene Name
Product Synonym Names
Presenilin-2 Antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid in phosphate buffered saline with 0.02% sodium azide, 50% glycerol.
Purity/Purification
Purified whole serum by affinity chromatography.
Preparation and Storage
Store at -20 degree C.
Storage in frost-free freezers is not recommended. This product should be stored undiluted.
Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 12 months from date of despatch
Molecular Weight
50,011 Da
OMIM
600759
3D Structure
ModBase 3D Structure for P49810
Immunogen
Synthetic human presenilin-2
Preperation
Antiserum to presenilin-2 was raised by repeated immunization of rabbits with highly purified antigen.
Applications Tested/Suitable for anti-PSEN2 antibody
Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
Application Notes for anti-PSEN2 antibody
IHC-Paraffin: 1:50-1:200
WB: 1:500-1:2000

Western Blot (WB) of anti-PSEN2 antibody

Western blot analysis of cell and tissue lysates using Rabbit anti presenilin-2 antibody
Rabbit Anti-PSEN2 Polyclonal Antibody – Cat# MBS225154

Immunohistochemistry (IHC) of anti-PSEN2 antibody

Immunohistochemistry of paraffin-embedded rat heart using Rabbit anti presenilin-2 antibody at a dilution of 1/100
Rabbit Anti-PSEN2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS225154

Immunohistochemistry (IHC) of anti-PSEN2 antibody

Immunohistochemistry of paraffin-embedded human kidney using Rabbit anti presenilin-2 antibody at a dilution of 1/100
Rabbit Anti-PSEN2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS225154

Other Notes

Small volumes of anti-PSEN2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PSEN2 purchase

MBS225154 is an antibody targeting PSEN2. Also known as Rabbit anti Presenilin-2. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PSEN2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Presenilin-2
NCBI Official Synonym Full Names
presenilin 2
NCBI Official Symbol
PSEN2
NCBI Official Synonym Symbols
AD4; PS2; AD3L; STM2; CMD1V
UniProt Protein Name
Presenilin-2
UniProt Synonym Protein Names
AD3LP; AD5; E5-1; STM-2
Protein Family
UniProt Gene Name
PSEN2
UniProt Synonym Gene Names
AD4; PS2; PSNL2; STM2; PS-2
NCBI Protein Information
presenilin-2

NCBI Summary for PSEN2

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008]
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UniProt Comments for PSEN2

Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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