IDE Antibody – Mouse Monoclonal

This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009]

IDE: Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia. Belongs to the peptidase M16 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell surface; EC 3.4.24.56; Nuclear receptor co-regulator; Protease

Chromosomal Location of Human Ortholog: 10q23-q25

Cellular Component: cell surface; cytoplasm; cytosol; extracellular space; mitochondrion; nucleoplasm; nucleus; peroxisomal matrix; peroxisome; plasma membrane

Molecular Function: ATP binding; ATPase activity; beta-amyloid binding; beta-endorphin binding; glycoprotein binding; insulin binding; metalloendopeptidase activity; peptide binding; protein binding; protein homodimerization activity; receptor binding; ubiquitin binding; viral receptor activity; zinc ion binding

Biological Process: beta-amyloid metabolic process; determination of adult life span; entry of virus into host cell; hormone catabolic process; insulin receptor signaling pathway; negative regulation of proteolysis; positive regulation of protein oligomerization; protein heterooligomerization; protein homooligomerization; protein homotetramerization; protein processing; proteolysis; proteolysis involved in cellular protein catabolic process