Rabbit Anti-CAMK2A Polyclonal Antibody – Cat# MBS225201

Western blot analysis of extracts from HEK-293 cells untreated or treated with PMA using Rabbit anti CaMK II alpha (pThr286) antibody. Cells were cultured in serum free media for 16-20 hours before treatment with PMA (200 nM) for 30 minutes

Camk II Alpha (CAMK2A) Antibody – Rabbit Polyclonal

Name: CAMK2A Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS225201
Price: 520 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS225201

Rabbit anti CaMK II alpha (pThr286) antibody recognizes calcium/calmodulin-dependent protein kinase type II subunit alpha (CaMK II alpha) also known as CaM kinase II subunit alpha, when phosphorylated at threonine 286. CaMK II alpha is a member of the CAMK… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

CaMK II Alpha (CAMK2A), Polyclonal Antibody

Full Product Name

Rabbit anti CaMK II Alpha (pThr286)

Product Gene Name

anti-CAMK2A antibody

Product Synonym Names

CaMK II Alpha (pThr286) Antibody

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse (Expected from Sequence), Rat (Expected from Sequence)

Form/Format

Liquid in phosphate buffered saline with 0.02% sodium azide, 50% glycerol.

Purity/Purification

Purified whole serum by affinity chromatography.

Preparation and Storage

Store at -20 degree C.
Storage in frost-free freezers is not recommended. This product should be stored undiluted.
Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 12 months from date of despatch

Molecular Weight

55,320 Da

OMIM

114078

3D Structure

ModBase 3D Structure for Q9UQM7

Immunogen

Phospho specific-peptide corresponding to residues surrounding threonine 286 of human CaMK II alpha

Preperation

Antiserum to CaMK II alpha (pThr286) was raised by repeated immunization of rabbits with highly purified antigen.

Applications Tested/Suitable for anti-CAMK2A antibody

Western Blot (WB)

Application Notes for anti-CAMK2A antibody

WB: 1:500-1:2000

Other Notes

Small volumes of anti-CAMK2A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CAMK2A purchase

MBS225201 is an antibody targeting CAMK2A. Also known as Rabbit anti CaMK II Alpha (pThr286). Reactive in Human, Mouse (Expected from Sequence), Rat (Expected from Sequence). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CAMK2A. It may not necessarily be applicable to this product.

NCBI GI #

296434552

NCBI GeneID

815

NCBI Accession #

Q9UQM7.2

UniProt Primary Accession #

Q9UQM7

UniProt Secondary Accession #

Q9UL21; Q9Y2H4; Q9Y352

UniProt Related Accession #

Q9UQM7

NCBI Official Full Name

Calcium/calmodulin-dependent protein kinase type II subunit alpha

NCBI Official Synonym Full Names

calcium/calmodulin dependent protein kinase II alpha

NCBI Official Symbol

CAMK2A

NCBI Official Synonym Symbols

CAMKA; MRD53

UniProt Protein Name

Calcium/calmodulin-dependent protein kinase type II subunit alpha

Protein Family

Calcium/calmodulin-dependent protein kinase

UniProt Gene Name

CAMK2A

UniProt Synonym Gene Names

CAMKA; KIAA0968; CaM kinase II subunit alpha; CaMK-II subunit alpha

NCBI Protein Information

calcium/calmodulin-dependent protein kinase type II subunit alpha

NCBI Summary for CAMK2A

The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2008]

UniProt Comments for CAMK2A

CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (). Phosphorylates transcription factor FOXO3 on 'Ser-298' (PubMed:23805378). Activates FOXO3 transcriptional activity ().

Research Articles on CAMK2A

1. The dynamics of calmodulin interactions with neurogranin and Ca(2+) /CAMKII alpha proteins has been reported.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CAMK2A antibody

Reference Product	PubMed Publications
CAMK2B antibody	>9 publications with CAMK2A and CAMK2B
CREB1 antibody	>1 publications with CAMK2A and CREB1
GRIN2A antibody	>1 publications with CAMK2A and GRIN2A
GRIN2B antibody	>1 publications with CAMK2A and GRIN2B

Pathways associated with anti-CAMK2A antibody

Products by Pathway	Pathway Diagram
Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies	Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram
Adrenergic Signaling In Cardiomyocytes Pathway antibodies	Adrenergic Signaling In Cardiomyocytes Pathway Diagram
Adrenergic Signaling In Cardiomyocytes Pathway antibodies	Adrenergic Signaling In Cardiomyocytes Pathway Diagram
Amphetamine Addiction Pathway antibodies	Amphetamine Addiction Pathway Diagram
Amphetamine Addiction Pathway antibodies	Amphetamine Addiction Pathway Diagram
BDNF Signaling Pathway antibodies	BDNF Signaling Pathway Diagram
CREB Phosphorylation Through The Activation Of CaMKII Pathway antibodies	CREB Phosphorylation Through The Activation Of CaMKII Pathway Diagram
CREB Phosphorylation Through The Activation Of Ras Pathway antibodies	CREB Phosphorylation Through The Activation Of Ras Pathway Diagram
Ca2+ Pathway antibodies	Ca2+ Pathway Diagram
Calcium Regulation In The Cardiac Cell Pathway antibodies	Calcium Regulation In The Cardiac Cell Pathway Diagram

Diseases associated with anti-CAMK2A antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>48 publications with CAMK2A and Nervous System Diseases
Brain Diseases Antibodies	>32 publications with CAMK2A and Brain Diseases
Seizures Antibodies	>8 publications with CAMK2A and Seizures
Pain Antibodies	>8 publications with CAMK2A and Pain
Memory Disorders Antibodies	>6 publications with CAMK2A and Memory Disorders
Movement Disorders Antibodies	>6 publications with CAMK2A and Movement Disorders
Learning Disorders Antibodies	>5 publications with CAMK2A and Learning Disorders
Inflammation Antibodies	>5 publications with CAMK2A and Inflammation
Cognition Disorders Antibodies	>4 publications with CAMK2A and Cognition Disorders
Necrosis Antibodies	>3 publications with CAMK2A and Necrosis

Organs/Tissues associated with anti-CAMK2A antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>140 publications with CAMK2A and Brain
Muscle Antibodies	>6 publications with CAMK2A and Muscle
Eye Antibodies	>4 publications with CAMK2A and Eye
Embryonic Tissue Antibodies	>4 publications with CAMK2A and Embryonic Tissue
Kidney Antibodies	>4 publications with CAMK2A and Kidney
Heart Antibodies	>3 publications with CAMK2A and Heart