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Apelin (APLN) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2401726

Endogenous lig and for APJ, an alternative coreceptor with CD4 for HIV-1infection. Inhibits HIV-1 entry in cells coexpressing CD4 and APJ.Apelin-36 has a greater inhibitory activity on HIV infection than othersynthetic apelin derivatives. the oral intake in… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Apelin (APLN), Polyclonal Antibody
Full Product Name
Anti-Apelin Antibody (C-Terminus)
Product Gene Name
anti-APLN antibody
Product Synonym Names
Mouse Monoclonal [clone 2B6] (IgG2a, k) to Human Apelin; APLN; AGTRL1 ligand; Apelin; APEL; Preproapelin; APJ endogenous ligand; XNPEP2
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Predicted: Mouse, Bovine, Rat
Form/Format
PBS, pH 7.3, 0.01% sodium azide, 30% glycerol.
Purity/Purification
Immunoaffinity Purified
Specificity
Recognizes endogenous levels of Apelin protein.
Preparation and Storage
Store at -20 degree C.
Aliquot to avoid freeze/thaw cycles.
Molecular Weight
8,569 Da
OMIM
300297
3D Structure
ModBase 3D Structure for Q9ULZ1
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the C-terminal region of human Apelin.
Conjugation
Unconjugated
Epitope
C-Terminus
Applications Tested/Suitable for anti-APLN antibody
Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
Application Notes for anti-APLN antibody
IHC-P: 1:100
WB: 1:500-1:1000

Immunohistochemistry (IHC) of anti-APLN antibody

Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
Rabbit Anti-APLN Polyclonal Antibody – Cat# MBS2401726

Immunohistochemistry (WB) of anti-APLN antibody

Human Lung, Respiratory Epithelium: Formalin-Fixed, Paraffin-Embedded (FFPE)
Rabbit Anti-APLN Polyclonal Antibody, Immunohistochemistry (WB) – Cat# MBS2401726

Western Blot (WB) of anti-APLN antibody

Western blot analysis of Apelin expression in HEK293T (A); HeLa (B) whole cell lysates.
Rabbit Anti-APLN Polyclonal Antibody, Western Blot (WB) – Cat# MBS2401726

Other Notes

Small volumes of anti-APLN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for APLN purchase

MBS2401726 is an antibody targeting APLN. Also known as Anti-Apelin Antibody (C-Terminus). Reactive in Human
Predicted: Mouse, Bovine, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for APLN. It may not necessarily be applicable to this product.

NCBI GI #
45120090
NCBI GeneID
8862
NCBI Accession #
NP_059109.3
UniProt Primary Accession #
Q9ULZ1
UniProt Secondary Accession #
Q4VY08; Q8WU89
UniProt Related Accession #
Q9ULZ1
GenBank Nucleotide #
NM_017413.4
NCBI Official Full Name
apelin preproprotein
NCBI Official Synonym Full Names
apelin
NCBI Official Symbol
APLN
NCBI Official Synonym Symbols
APEL; XNPEP2
UniProt Protein Name
Apelin
UniProt Synonym Protein Names
APJ endogenous ligand
Protein Family
Apelin
UniProt Gene Name
APLN
UniProt Synonym Gene Names
APEL
NCBI Protein Information
apelin

NCBI Summary for APLN

This gene encodes a peptide that functions as an endogenous ligand for the G-protein coupled apelin receptor. The encoded preproprotein is proteolytically processed into biologically active C-terminal peptide fragments. These peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1. [provided by RefSeq, Feb 2016]
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UniProt Comments for APLN

Endogenous ligand for the apelin receptor (APLNR) (PubMed:10525157). Drives internalization of the apelin receptor (). Apelin-36 dissociates more hardly than (pyroglu)apelin-13 from APLNR (). Hormone involved in the regulation of cardiac precursor cell movements during gastrulation and heart morphogenesis (). Has an inhibitory effect on cytokine production in response to T-cell receptor/CD3 cross-linking; the oral intake of apelin in the colostrum and the milk might therefore modulate immune responses in neonates (). Plays a role in early coronary blood vessels formation (). Mediates myocardial contractility in an ERK1/2-dependent manner (). May also have a role in the central control of body fluid homeostasis by influencing vasopressin release and drinking behavior ().
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Research Articles on APLN

1. Studies suggest that apelin/APJ system may be applied to the treatment of cancers by regulating apoptosis, which may play a vital role in anticancer therapy [review].

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-APLN antibody

 Reference Product  PubMed Publications
 APLNR antibody  >140 publications with APLN and APLNR
 POMC antibody  >3 publications with APLN and POMC
 CCR5 antibody  >3 publications with APLN and CCR5

Pathways associated with anti-APLN antibody

 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram

Diseases associated with anti-APLN antibody

 Disease Name  Pubmed Publications
 Hypertension Antibodies  >50 publications with APLN and Hypertension
 Insulin Resistance Antibodies  >48 publications with APLN and Insulin Resistance
 Inflammation Antibodies  >35 publications with APLN and Inflammation
 Disease Models, Animal Antibodies  >27 publications with APLN and Disease Models, Animal
 Hypertrophy Antibodies  >20 publications with APLN and Hypertrophy
 Necrosis Antibodies  >17 publications with APLN and Necrosis
 Kidney Diseases Antibodies  >16 publications with APLN and Kidney Diseases
 Brain Diseases Antibodies  >15 publications with APLN and Brain Diseases
 Myocardial Infarction Antibodies  >14 publications with APLN and Myocardial Infarction
 Neoplasms Antibodies  >14 publications with APLN and Neoplasms

Organs/Tissues associated with anti-APLN antibody

 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >117 publications with APLN and Vascular
 Heart Antibodies  >103 publications with APLN and Heart
 Brain Antibodies  >57 publications with APLN and Brain
 Connective Tissue Antibodies  >39 publications with APLN and Connective Tissue
 Kidney Antibodies  >32 publications with APLN and Kidney
 Lung Antibodies  >23 publications with APLN and Lung
 Stomach Antibodies  >19 publications with APLN and Stomach
 Embryonic Tissue Antibodies  >17 publications with APLN and Embryonic Tissue
 Ovary Antibodies  >9 publications with APLN and Ovary
 Nerve Antibodies  >9 publications with APLN and Nerve
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