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ARL6IP1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS240471

Apoptosis is important for normal development and tissue homeostasis. It is mediated by various caspases and ultimately results in the activation of endogenous endonucleases that degrade cellular DNA. Although apoptosis induced by endoplasmic reticulum (ER)… More details

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Product Overview

Product Name
ARL6IP1 / ARMER, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human ARL6IP1 / ARMER
Product Gene Name
Product Synonym Gene Name
ARMER
Product Synonym Names
Anti-ARL6IP1 / ARMER Antibody (C-Terminus) IHC-plus; ARL6IP1; AIP1; ARL-6-interacting protein 1; ARL6IP; ARMER; AIP-1; KIAA0069; Human ARL6IP1; ARMER
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
PBS, 0.02% sodium azide.
Purity/Purification
Ion exchange Chromatography
Concentration
1 mg/ml (lot specific)
Specificity
peptide corresponding to 15 amino acids near the C-terminus of human ARMER
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
Molecular Weight
17,158 Da
OMIM
gene 615685
3D Structure
ModBase 3D Structure for Q15041
Target Species
Human
Immunogen Description
Synthetic peptide from human ARL6IP1 / ARMER.
Immunogen Type
Synthetic peptide
Immunogen
ARL6IP1 / ARMER antibody was raised against synthetic peptide from human ARL6IP1 / ARMER.
Antigen Modification
C-Terminus

Product Categories/Family for anti-ARL6IP1 antibody

Applications Tested/Suitable for anti-ARL6IP1 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-ARL6IP1 antibody
IHC-P (2.5 ug/ml), WB (0.5 - 2 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...

Immunohistochemistry (IHC) of anti-ARL6IP1 antibody

Anti-ARL6IP1 / ARMER antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-ARL6IP1 Polyclonal Antibody – Cat# MBS240471

Immunofluorescence (IF) of anti-ARL6IP1 antibody

Immunofluorescence of ARMER in Mouse Intestine cells with ARMER antibody at 2 ug/ml.
Rabbit Anti-ARL6IP1 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS240471

Western Blot (WB) of anti-ARL6IP1 antibody

Western blot ana-lysis of ARMER in mouse small intestine tissue lysates with ARMER antibody at (A) 0.5, (B) 1, and (C) 2 ug/ml.
Rabbit Anti-ARL6IP1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS240471

Other Notes

Small volumes of anti-ARL6IP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ARL6IP1 purchase

MBS240471 is an antibody targeting ARL6IP1. Also known as Rabbit Polyclonal to Human ARL6IP1 / ARMER. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ARL6IP1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
ADP-ribosylation factor-like protein 6-interacting protein 1
NCBI Official Synonym Full Names
ADP-ribosylation factor-like 6 interacting protein 1
NCBI Official Symbol
ARL6IP1
NCBI Official Synonym Symbols
AIP1; ARMER; SPG61; ARL6IP
UniProt Protein Name
ADP-ribosylation factor-like protein 6-interacting protein 1
UniProt Gene Name
ARL6IP1
UniProt Synonym Gene Names
ARL6IP; KIAA0069; ARL-6-interacting protein 1; Aip-1
UniProt Entry Name
AR6P1_HUMAN
NCBI Protein Information
ADP-ribosylation factor-like protein 6-interacting protein 1; aip-1; ARL-6-interacting protein 1; apoptotic regulator in the membrane of the endoplasmic reticulum

NCBI Summary for ARL6IP1

This gene belongs to the ARL6ip family and encodes a transmembrane protein that is predominantly localized to intracytoplasmic membranes. It is highly expressed in early myeloid progenitor cells and thought to be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation. Mutations in this gene are associated with spastic paraplegia 61 (SPG61). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]
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UniProt Comments for ARL6IP1

ARL6IP: May be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation. Belongs to the ARL6ip family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 16p12-p11.2

Cellular Component: membrane; integral to membrane; translocon complex; cytosol

Molecular Function: protein binding

Biological Process: cotranslational protein targeting to membrane

Disease: Spastic Paraplegia 61, Autosomal Recessive
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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