Goat Anti-NOXO1 Polyclonal Antibody – Cat# MBS240650

Anti-NOXO1 antibody IHC of human renal tubular epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

NOXO1 Antibody – Goat Polyclonal

Name: NOXO1 Antibody; Polyclonal; Goat; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS240650
Price: 625 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS240650

NADPH oxidases (NOXs) catalyze the transfer of electrons from NADPH to molecular oxygen to generate reactive oxygen species. NOXO1 is a NOX organizer that targets NOX activator to NOX1 and also targets NOX1 to different subcellular compartments. NOXO1 is… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

NOXO1, Polyclonal Antibody

Full Product Name

Goat Polyclonal to Human NOXO1

Product Gene Name

anti-NOXO1 antibody

Product Synonym Names

Anti-NOXO1 Antibody (C-Terminus) IHC-plus; NOXO1; NADPH oxidase organizer 1; Nox-organizing protein 1; p41NOX; p41NOXA; p41NOXC; Regulatory protein P41NOX; Nox organizer 1; p41NOXB; SH3PXD5; SNX28; Human NOXO1

Clonality

Polyclonal

Host

Goat

Species Reactivity

Gorilla, Human
Predicted Reactivity: Gibbon (at least 90% immunogen sequence identity)

Form/Format

Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide

Purity/Purification

Immunoaffinity Purified

Concentration

0.5 mg/ml (lot specific)

Specificity

Human NOXO1. This antibody is expected to recognise all three reported isoforms (as represented by NP_653204.1, NP_751907.1and NP_751908.1).

Preparation and Storage

Store at -20 degree C. Minimize freezing and thawing.

Molecular Weight

40,668 Da

OMIM

611256

3D Structure

ModBase 3D Structure for Q8NFA2

Target Species

Human

Immunogen Description

Synthetic peptide RGCVDSVPHPTTEQ from the C-terminus of human NOXO1 (NP_653204.1; NP_751907.1; NP_751907.1). Percent identity by BLAST analysis: Human, Gorilla (100%); Gibbon (93%).

Immunogen Type

Synthetic peptide

Immunogen

NOXO1 antibody was raised against synthetic peptide RGCVDSVPHPTTEQ from the C-terminus of human NOXO1 (NP_653204.1; NP_751907.1; NP_751907.1). Percent identity by BLAST analysis: Human, Gorilla (100%); Gibbon (93%).

Antigen Modification

C-Terminus

Applications Tested/Suitable for anti-NOXO1 antibody

Immunohistochemistry (IHC - Paraffin), ELISA (EIA)

Application Notes for anti-NOXO1 antibody

ELISA (1:16000), IHC-P (10 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibod...

Other Notes

Small volumes of anti-NOXO1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NOXO1 purchase

MBS240650 is an antibody targeting NOXO1. Also known as Goat Polyclonal to Human NOXO1. Reactive in Gorilla, Human
Predicted Reactivity: Gibbon (at least 90% immunogen sequence identity). Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for NOXO1. It may not necessarily be applicable to this product.

NCBI GI #

41281828

NCBI GeneID

124056

NCBI Accession #

NP_751908.1

UniProt Primary Accession #

Q8NFA2

UniProt Secondary Accession #

Q86YM1; Q8NFA3; Q96B73

UniProt Related Accession #

Q8NFA2

GenBank Nucleotide #

NM_172168.2

NCBI Official Full Name

NADPH oxidase organizer 1 isoform c

NCBI Official Synonym Full Names

NADPH oxidase organizer 1

NCBI Official Symbol

NOXO1

NCBI Official Synonym Symbols

SNX28; P41NOX; P41NOXA; P41NOXB; P41NOXC; SH3PXD5

UniProt Protein Name

NADPH oxidase organizer 1

UniProt Synonym Protein Names

NADPH oxidase regulatory protein; Nox organizer 1; Nox-organizing protein 1; SH3 and PX domain-containing protein 5

Protein Family

NADPH oxidase organizer

UniProt Gene Name

NOXO1

UniProt Synonym Gene Names

P41NOX; SH3PXD5

UniProt Entry Name

NOXO1_HUMAN

NCBI Protein Information

NADPH oxidase organizer 1; Nox organizer 1; nox-organizing protein 1; regulatory protein P41NOX; NADPH oxidase regulatory protein; SH3 and PX domain-containing protein 5

NCBI Summary for NOXO1

This gene encodes an NADPH oxidase (NOX) organizer, which positively regulates NOX1 and NOX3. The protein contains a PX domain and two SH3 domains. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012]

UniProt Comments for NOXO1

NOXO1: Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: NADPH oxidase complex

Molecular Function: identical protein binding; protein binding; enzyme binding; phospholipid binding; superoxide-generating NADPH oxidase activator activity; phosphoinositide binding

Biological Process: positive regulation of catalytic activity; extracellular matrix disassembly; superoxide metabolic process; regulation of hydrogen peroxide metabolic process

Research Articles on NOXO1

1. TNF-alpha/TNFR1 signaling promotes gastric tumorigenesis through induction of Noxo1 and Gna14 in tumor cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NOXO1 antibody

Reference Product	PubMed Publications
NOX1 antibody	>71 publications with NOXO1 and NOX1
NOXA1 antibody	>64 publications with NOXO1 and NOXA1
RAC1 antibody	>22 publications with NOXO1 and RAC1
NOX3 antibody	>20 publications with NOXO1 and NOX3
NOX4 antibody	>19 publications with NOXO1 and NOX4
CYBB antibody	>18 publications with NOXO1 and CYBB
CYBA antibody	>12 publications with NOXO1 and CYBA
NCF2 antibody	>2 publications with NOXO1 and NCF2

Pathways associated with anti-NOXO1 antibody

Products by Pathway	Pathway Diagram
RAC1 Signaling Pathway antibodies	RAC1 Signaling Pathway Diagram

Diseases associated with anti-NOXO1 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>11 publications with NOXO1 and Inflammation
Necrosis Antibodies	>7 publications with NOXO1 and Necrosis
Disease Models, Animal Antibodies	>5 publications with NOXO1 and Disease Models, Animal
Death Antibodies	>5 publications with NOXO1 and Death
Cell Transformation, Neoplastic Antibodies	>3 publications with NOXO1 and Cell Transformation, Neoplastic
Cardiovascular Diseases Antibodies	>3 publications with NOXO1 and Cardiovascular Diseases
Fibrosis Antibodies	>2 publications with NOXO1 and Fibrosis
Lung Diseases Antibodies	>2 publications with NOXO1 and Lung Diseases
Nervous System Diseases Antibodies	>2 publications with NOXO1 and Nervous System Diseases
Skin Neoplasms Antibodies	>1 publications with NOXO1 and Skin Neoplasms

Organs/Tissues associated with anti-NOXO1 antibody

Organ/Tissue Name	Pubmed Publications
Intestine Antibodies	>6 publications with NOXO1 and Intestine
Liver Antibodies	>5 publications with NOXO1 and Liver
Lung Antibodies	>5 publications with NOXO1 and Lung
Brain Antibodies	>4 publications with NOXO1 and Brain
Embryonic Tissue Antibodies	>3 publications with NOXO1 and Embryonic Tissue
Skin Antibodies	>2 publications with NOXO1 and Skin
Testis Antibodies	>2 publications with NOXO1 and Testis
Placenta Antibodies	>1 publications with NOXO1 and Placenta