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Sorcin (SRI) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1496606

MBS1496606 is an antibody targeting SRI. Also known as Rabbit anti-human Sorcin polyclonal Antibody(SRI). Reactive in Human. Host: Rabbit. More details

$230 / 0.05 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Sorcin (SRI), Polyclonal Antibody
Full Product Name
Rabbit anti-human Sorcin polyclonal Antibody(SRI)
Product Gene Name
anti-SRI antibody
Product Synonym Names
Sorcin; 22 kDa protein; CP-22; CP22; V19; SRI
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid
Purity/Purification
Antigen Affinity Purified
Preparation and Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
OMIM
182520
3D Structure
ModBase 3D Structure for P30626
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Conjugate
Non-conjugated
Target Names
SRI
Immunogen
Recombinant human Sorcin protein (1-198aa)
Immunogen Species
Homo sapiens (Human)
Research Area
Signal Transduction
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-12301
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-SRI antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-SRI antibody
Recommended dilution: Western Blot:1:200-1000
Immunohistochemistry:1:20-1:200

Western Blot (WB) of anti-SRI antibody

Western blot
All lanes: SRI antibody at 2ug/ml
Lane 1:HepG2 whole cell lysate
Lane 2:Hela whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 22,21 kDa
Observed band size: 22 kDa
Rabbit Anti-SRI Polyclonal Antibody – Cat# MBS1496606

Immunohistochemistry (IHC) of anti-SRI antibody

Immunohistochemistry of paraffin-embedded human small intestine using MBS1496606 at dilution 1:100
Rabbit Anti-SRI Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS1496606

Immunohistochemistry (IHC) of anti-SRI antibody

Immunohistochemistry of paraffin-embedded human liver using MBS1496606 at dilution 1:100
Rabbit Anti-SRI Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS1496606

Other Notes

Small volumes of anti-SRI antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SRI. It may not necessarily be applicable to this product.

NCBI GI #
379317145
NCBI GeneID
6717
NCBI Accession #
NP_001243820.1
UniProt Primary Accession #
P30626
UniProt Secondary Accession #
A8MTH6; B4DKK2; D6W5Q0
UniProt Related Accession #
P30626
GenBank Nucleotide #
NM_001256891.1
NCBI Official Full Name
sorcin isoform C
NCBI Official Synonym Full Names
sorcin
NCBI Official Symbol
SRI
NCBI Official Synonym Symbols
SCN; V19; CP22; CP-22
UniProt Protein Name
Sorcin
UniProt Synonym Protein Names
22 kDa protein; CP-22; CP22; V19
Protein Family
Sorcin
UniProt Gene Name
SRI
UniProt Synonym Gene Names
CP22
UniProt Entry Name
SORCN_HUMAN
NCBI Protein Information
sorcin

NCBI Summary for SRI

This gene encodes a calcium-binding protein with multiple E-F hand domains that relocates from the cytoplasm to the sarcoplasmic reticulum in response to elevated calcium levels. In addition to regulating intracellular calcium homeostasis it also modulates excitation-contraction coupling in the heart. Alternative splicing results in multiple transcript variants encoding distinct proteins. Multiple pseudogenes exist for this gene. [provided by RefSeq, Mar 2012]
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UniProt Comments for SRI

SRI: Calcium-binding protein that modulates excitation- contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels.

Protein type: Calcium-binding

Chromosomal Location of Human Ortholog: 7q21.1

Cellular Component: cytoplasm; cytosol; endoplasmic reticulum membrane; membrane; mitochondrion; nerve terminal; nucleoplasm; sarcoplasmic reticulum; sarcoplasmic reticulum membrane; smooth endoplasmic reticulum; T-tubule; Z disc

Molecular Function: calcium channel regulator activity; calcium ion binding; calcium-dependent cysteine-type endopeptidase activity; identical protein binding; protease binding; protein binding; protein heterodimerization activity; receptor binding

Biological Process: calcium ion transport; cytoplasmic sequestering of transcription factor; heart development; intracellular sequestering of iron ion; muscle development; negative regulation of heart rate; positive regulation of release of sequestered calcium ion into cytosol; proteolysis; regulation of action potential; regulation of calcium ion transport; regulation of heart contraction; regulation of striated muscle contraction; signal transduction; transport
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Research Articles on SRI

1. Sorcin is highly expressed in the heart and in the brain, and overexpressed in many cancer cells. [Review]

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SRI antibody

 Reference Product  PubMed Publications
 RYR2 antibody  >12 publications with SRI and RYR2
 GCA antibody  >3 publications with SRI and GCA
 UBC antibody  >3 publications with SRI and UBC
 PLK1 antibody  >2 publications with SRI and PLK1
 PSEN2 antibody  >2 publications with SRI and PSEN2
 TRAP1 antibody  >1 publications with SRI and TRAP1
 ANXA7 antibody  >1 publications with SRI and ANXA7

Pathways associated with anti-SRI antibody

 Products by Pathway  Pathway Diagram
 Cardiac Conduction Pathway antibodies  Cardiac Conduction Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
 Ion Homeostasis Pathway antibodies  Ion Homeostasis Pathway Diagram
 Ion Transport By P-type ATPases Pathway antibodies  Ion Transport By P-type ATPases Pathway Diagram
 Muscle Contraction Pathway antibodies  Muscle Contraction Pathway Diagram
 Platelet Calcium Homeostasis Pathway antibodies  Platelet Calcium Homeostasis Pathway Diagram
 Platelet Homeostasis Pathway antibodies  Platelet Homeostasis Pathway Diagram
 Reduction Of Cytosolic Ca++ Levels Pathway antibodies  Reduction Of Cytosolic Ca++ Levels Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram

Diseases associated with anti-SRI antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >1061 publications with SRI and Nervous System Diseases
 Poisoning Antibodies  >524 publications with SRI and Poisoning
 Pain Antibodies  >479 publications with SRI and Pain
 Brain Diseases Antibodies  >469 publications with SRI and Brain Diseases
 Skin Diseases Antibodies  >457 publications with SRI and Skin Diseases
 Carcinoma Antibodies  >376 publications with SRI and Carcinoma
 Gastrointestinal Diseases Antibodies  >330 publications with SRI and Gastrointestinal Diseases
 Hypertension Antibodies  >298 publications with SRI and Hypertension
 Lung Diseases Antibodies  >292 publications with SRI and Lung Diseases
 Inflammation Antibodies  >281 publications with SRI and Inflammation

Organs/Tissues associated with anti-SRI antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2048 publications with SRI and Blood
 Brain Antibodies  >806 publications with SRI and Brain
 Heart Antibodies  >753 publications with SRI and Heart
 Vascular Antibodies  >510 publications with SRI and Vascular
 Liver Antibodies  >486 publications with SRI and Liver
 Bone Antibodies  >473 publications with SRI and Bone
 Kidney Antibodies  >452 publications with SRI and Kidney
 Skin Antibodies  >406 publications with SRI and Skin
 Muscle Antibodies  >382 publications with SRI and Muscle
 Eye Antibodies  >354 publications with SRI and Eye
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