Rabbit Anti-MTO1 Polyclonal Antibody – Cat# MBS241721

Anti-MTO1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.

MTO1 Antibody – Rabbit Polyclonal

Name: MTO1 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS241721
Price: 650 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS241721

MBS241721 is an antibody targeting MTO1. Also known as Rabbit Polyclonal to Human MTO1. Reactive in Human. Host: Rabbit. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

MTO1, Polyclonal Antibody

Full Product Name

Rabbit Polyclonal to Human MTO1

Product Gene Name

anti-MTO1 antibody

Product Synonym Names

Anti-MTO1 Antibody (C-Terminus) IHC-plus; MTO1; COXPD10; CGI-02; Homolog of yeast Mto1; Mitochondrial MTO1-3; Human MTO1

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human

Form/Format

PBS, 0.01% sodium azide, 50% glycerol.

Purity/Purification

Immunoaffinity Purified

Concentration

0.5 mg/ml (lot specific)

Specificity

synthetic peptide corresponding to C-terminal residues of human Protein MTO1 homolog, mitochondrial precursor

Preparation and Storage

+4 degree C or -20 degree C, Avoid repeated freezing and thawing.

Molecular Weight

81,538 Da

OMIM

gene 614702

3D Structure

ModBase 3D Structure for Q9Y2Z2

Target Species

Human

Immunogen Description

Synthetic peptide from human MTO1.

Immunogen Type

Synthetic peptide

Immunogen

MTO1 antibody was raised against synthetic peptide from human MTO1.

Antigen Modification

C-Terminus

Applications Tested/Suitable for anti-MTO1 antibody

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

Application Notes for anti-MTO1 antibody

ELISA (1 ug/ml), IHC-P (20 ug/ml), WB (1 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Other Notes

Small volumes of anti-MTO1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MTO1. It may not necessarily be applicable to this product.

NCBI GI #

74024895

NCBI GeneID

25821

NCBI Accession #

NP_036255.2

UniProt Primary Accession #

Q9Y2Z2

UniProt Secondary Accession #

Q5SWL2; Q5SWL3; Q5SWL4; Q8NDN7; Q8WZ57; Q96FE6; Q9BS06; B3KQB5

UniProt Related Accession #

Q9Y2Z2

GenBank Nucleotide #

NM_012123.3

NCBI Official Full Name

protein MTO1 homolog, mitochondrial isoform a

NCBI Official Synonym Full Names

mitochondrial tRNA translation optimization 1

NCBI Official Symbol

MTO1

NCBI Official Synonym Symbols

CGI-02; COXPD10

UniProt Protein Name

Protein MTO1 homolog, mitochondrial

Protein Family

Mitochondrial translation optimization protein

UniProt Gene Name

MTO1

UniProt Entry Name

MTO1_HUMAN

NCBI Protein Information

protein MTO1 homolog, mitochondrial; mitochondrial MTO1-3; homolog of yeast Mto1; mitochondrial translation optimization 1 homolog

NCBI Summary for MTO1

This gene encodes a mitochondrial protein thought to be involved in mitochondrial tRNA modification. The encoded protein may also play a role in the expression of the non-syndromic and aminoglycoside-induced deafness phenotypes associated with a specific mutation in the mitochondrial 12S rRNA gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

UniProt Comments for MTO1

MTO1: Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs. Defects in MTO1 are the cause of combined oxidative phosphorylation deficiency type 10 (COXPD10). An autosomal recessive disorder resulting in variable defects of mitochondrial oxidative respiration. Affected individuals present in infancy with hypertrophic cardiomyopathy and lactic acidosis. The severity is variable, but can be fatal in the most severe cases. Belongs to the MnmG family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA processing

Chromosomal Location of Human Ortholog: 6q13

Cellular Component: mitochondrion

Molecular Function: FAD binding

Disease: Combined Oxidative Phosphorylation Deficiency 10

Research Articles on MTO1

1. Nuclear-encoded mitochondrial MTO1 and MRPL41 are regulated in an opposite epigenetic mode based on estrogen receptor status in breast cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-MTO1 antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>6 publications with MTO1 and Nervous System Diseases
Acidosis Antibodies	>4 publications with MTO1 and Acidosis
Cardiovascular Diseases Antibodies	>4 publications with MTO1 and Cardiovascular Diseases

Organs/Tissues associated with anti-MTO1 antibody

Organ/Tissue Name	Pubmed Publications
Heart Antibodies	>2 publications with MTO1 and Heart
Brain Antibodies	>2 publications with MTO1 and Brain
Liver Antibodies	>1 publications with MTO1 and Liver
Blood Antibodies	>1 publications with MTO1 and Blood
Mammary Gland Antibodies	>1 publications with MTO1 and Mammary Gland