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TMEM123 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS241868

MBS241868 is an antibody targeting TMEM123. Also known as Rabbit Polyclonal (IgG) to Human TMEM123 / Porimin. Reactive in Gibbon, Gorilla, Human, Monkey, RabbitPredicted Reactivity: Mouse, Rat, Hamster, Horse, Chicken (at least 90% immunogen sequence… More details

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Product Overview

Online Datasheet in PDF
Product Name
TMEM123 / Porimin, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal (IgG) to Human TMEM123 / Porimin
Product Gene Name
Product Synonym Names
Anti-TMEM123 / Porimin Antibody (aa173-188) IHC-plus; TMEM123; KCT-3; KCT3; PORMIN; Transmembrane protein 123; Porimin; Serine/threonine-rich receptor; Human TMEM123; Porimin
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Gibbon, Gorilla, Human, Monkey, Rabbit
Predicted Reactivity: Mouse, Rat, Hamster, Horse, Chicken (at least 90% immunogen sequence identity)
Form/Format
PBS, 0.05% sodium azide.
Purity/Purification
Protein G Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
A synthetic peptide corresponding to amino acids 173-188 SRRGIRYRTIDEHDAI of human Porimin; GenBank no. AAG2164.1. This sequence is 100% conserved in cow, and 93% conserved in rat, mouse, and chicken.
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
Molecular Weight
19,678 Da
OMIM
606356
3D Structure
ModBase 3D Structure for Q8N131
Target Species
Human
Immunogen Description
This antibody was generated by immunizing rabbits with a synthetic peptide corresponding to amino acids 173-188 SRRGIRYRTIDEHDAIof human Porimin; GenBank no. AAG2164.1.
Immunogen Type
Synthetic peptide
Immunogen
TMEM123 / Porimin antibody was raised against this antibody was generated by immunizing rabbits with a synthetic peptide corresponding to amino acids 173-188 SRRGIRYRTIDEHDAIof human Porimin; GenBank no. AAG2164.1. This sequence is 100% conserved in cow, and 93% conserved in rat, mouse, and chicken. Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Elephant, Rabbit (100%); Mouse, Rat, Hamster, Horse, Chicken (94%).
Antigen Modification
aa173-188
Applications Tested/Suitable for anti-TMEM123 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-TMEM123 antibody
IHC-P (5 ug/ml), WB (1 - 3 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-TMEM123 antibody

Anti-TMEM123 antibody IHC of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-TMEM123 Polyclonal Antibody – Cat# MBS241868

Western Blot (WB) of anti-TMEM123 antibody

Western blot of Porimin using antibody at 2 ug/ml?dilution against 20 ug/lane of?HL60 cell lysate.
Rabbit Anti-TMEM123 Polyclonal Antibody, Western Blot (WB) – Cat# MBS241868

Other Notes

Small volumes of anti-TMEM123 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TMEM123. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
porimin
NCBI Official Synonym Full Names
transmembrane protein 123
NCBI Official Symbol
TMEM123
NCBI Official Synonym Symbols
KCT3; PORMIN; PORIMIN
UniProt Protein Name
Porimin
UniProt Synonym Protein Names
Keratinocytes-associated transmembrane protein 3; KCT-3; Pro-oncosis receptor inducing membrane injury; Transmembrane protein 123
Protein Family
UniProt Gene Name
TMEM123
UniProt Synonym Gene Names
KCT3; KCT-3
UniProt Entry Name
PORIM_HUMAN
NCBI Protein Information
porimin; KCT-3; serine/threonine-rich receptor; pro oncosis receptor inducing membrane injury; pro-oncosis receptor inducing membrane injury; keratinocytes associated transmembrane protein 3; keratinocytes-associated transmembrane protein 3

NCBI Summary for TMEM123

This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death. [provided by RefSeq, Jul 2008]
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UniProt Comments for TMEM123

TMEM123: Implicated in oncotic cell death, characterized by cell swelling, organelle swelling, vacuolization and increased membrane permeability. Belongs to the CD164 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q22.1

Cellular Component: integral to membrane; external side of plasma membrane

Molecular Function: receptor activity
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-TMEM123 antibody

 Disease Name  Pubmed Publications
 Weight Loss Antibodies  >1 publications with TMEM123 and Weight Loss
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