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AKR1A1 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS242196

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in… More details

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Product Overview

Product Name
AKR1A1, Polyclonal Antibody
Full Product Name
Goat Polyclonal to Human AKR1A1
Product Gene Name
anti-AKR1A1 antibody
Product Synonym Names
Anti-AKR1A1 Antibody (C-Terminus) IHC-plus; AKR1A1; ALDR1; Aldehyde reductase; Alcohol dehydrogenase; ARM; DD3; Dihydrodiol dehydrogenase 3; ALR; Human AKR1A1
Clonality
Polyclonal
Host
Goat
Species Reactivity
Bat, Gibbon, Bovine, Dog, Xenopus, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Orangutan, Pig, Rabbit, Rat
Predicted Reactivity: Chicken, Zebrafish (at least 90% immunogen sequence identity)
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
Human AKR1A1. Both reported variants (NP_006057.1and NP_697021.1) represent identical protein
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
36,573 Da
OMIM
103830
3D Structure
ModBase 3D Structure for P14550
Target Species
Human
Immunogen Description
Synthetic peptide C-DAGHPLYPFNDPY from the C-terminus of human AKR1A1 (NP_006057.1; NP_697021.1).
Immunogen Type
Synthetic peptide
Immunogen
AKR1A1 antibody was raised against synthetic peptide C-DAGHPLYPFNDPY from the C-terminus of human AKR1A1 (NP_006057.1; NP_697021.1). Percent identity by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Marmoset, Mouse, Rat, Hamster, Elephant, Dog, Bat, Bovine, Horse, Rabbit, Pig, Xenopus (100%); Turkey, Chicken, Platypus, Catfish, Zebrafish (92%); Opossum, Salmon, Stickleback, Pike (85%).
Antigen Modification
C-Terminus
Applications Tested/Suitable for anti-AKR1A1 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-AKR1A1 antibody
ELISA (1:16000), IHC-P (2.5 ug/ml), WB (0.5 - 2 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-AKR1A1 antibody

Anti-AKR1A1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Goat Anti-AKR1A1 Polyclonal Antibody – Cat# MBS242196

Western Blot (WB) of anti-AKR1A1 antibody

Antibody staining (1 ug/ml) of Human Placenta lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 1 hour. Detected by Western blot of chemiluminescence.
Goat Anti-AKR1A1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS242196

Western Blot (WB) of anti-AKR1A1 antibody

HEK293 overexpressing AKR1A1 (RC200302) and probed with the antibody (mock transfection in first lane).
Goat Anti-AKR1A1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS242196

Other Notes

Small volumes of anti-AKR1A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AKR1A1 purchase

MBS242196 is an antibody targeting AKR1A1. Also known as Goat Polyclonal to Human AKR1A1. Reactive in Bat, Gibbon, Bovine, Dog, Xenopus, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Orangutan, Pig, Rabbit, Rat
Predicted Reactivity: Chicken, Zebrafish (at least 90% immunogen sequence identity). Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for AKR1A1. It may not necessarily be applicable to this product.

NCBI GI #
5174391
NCBI GeneID
10327
NCBI Accession #
NP_006057.1
UniProt Primary Accession #
P14550
UniProt Secondary Accession #
Q6IAZ4; A8KAL8; D3DQ04
UniProt Related Accession #
P14550
GenBank Nucleotide #
NM_006066.3
NCBI Official Full Name
alcohol dehydrogenase
NCBI Official Synonym Full Names
aldo-keto reductase family 1, member A1 (aldehyde reductase)
NCBI Official Symbol
AKR1A1
NCBI Official Synonym Symbols
ALR; ARM; DD3; ALDR1; HEL-S-6
UniProt Protein Name
Alcohol dehydrogenase [NADP(+)]
UniProt Synonym Protein Names
Aldehyde reductase; Aldo-keto reductase family 1 member A1
Protein Family
Alcohol dehydrogenase
UniProt Gene Name
AKR1A1
UniProt Synonym Gene Names
ALDR1; ALR
UniProt Entry Name
AK1A1_HUMAN
NCBI Protein Information
alcohol dehydrogenase [NADP(+)]; alcohol dehydrogenase [NADP(+)]; HEL-S-165mP; aldehyde reductase; dihydrodiol dehydrogenase 3; epididymis secretory protein Li 6; aldo-keto reductase family 1 member A1; epididymis secretory sperm binding protein Li 165mP

NCBI Summary for AKR1A1

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Multiple alternatively spliced transcript variants of this gene exist, all encoding the same protein. [provided by RefSeq, Jan 2011]
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UniProt Comments for AKR1A1

AKR1A1: Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4- nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D- glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN). Belongs to the aldo/keto reductase family.

Protein type: Lipid Metabolism - glycerolipid; Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 1.1.1.2; Oxidoreductase

Chromosomal Location of Human Ortholog: 1p33-p32

Cellular Component: extracellular space; apical plasma membrane; cytosol

Molecular Function: L-glucuronate reductase activity; electron carrier activity; aldehyde reductase activity

Biological Process: aldehyde catabolic process; L-ascorbic acid biosynthetic process; D-glucuronate catabolic process; glucose metabolic process; aldehyde metabolic process
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Research Articles on AKR1A1

1. prostaglandin F synthase activity of human and bovine aldo-keto reductases

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-AKR1A1 antibody

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