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MAOB Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS242608

MBS242608 is an antibody targeting MAOB. Also known as Goat Polyclonal to Human MAOB / Monoamine Oxidase B. Reactive in Gibbon, Bovine, Guinea pig, Gorilla, Horse, Human, Monkey, Orangutan, Pig, RabbitPredicted Reactivity: Mouse, Rat, Dog (at least 90%… More details

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Product Overview

Online Datasheet in PDF
Product Name
MAOB / Monoamine Oxidase B, Polyclonal Antibody
Full Product Name
Goat Polyclonal to Human MAOB / Monoamine Oxidase B
Product Gene Name
anti-MAOB antibody
Product Synonym Names
Anti-MAOB / Monoamine Oxidase B Antibody (Internal) IHC-plus; MAOB; Adrenalin oxidase; MAO; brain; MAO-B; Monoamine oxidase type B; MAO; platelet; Tyramine oxidase; Monoamine oxidase B; Human MAOB; Monoamine Oxidase B
Clonality
Polyclonal
Host
Goat
Species Reactivity
Gibbon, Bovine, Guinea pig, Gorilla, Horse, Human, Monkey, Orangutan, Pig, Rabbit
Predicted Reactivity: Mouse, Rat, Dog (at least 90% immunogen sequence identity)
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
Human MAOB. This antibody is not expected to cross-react with MAOA.
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
46,539 Da
OMIM
309860
3D Structure
ModBase 3D Structure for P27338
Target Species
Human
Immunogen Description
Synthetic peptide C-HKARKLARLTKEE from an internal region of human MAOB (NP_000889.3). Percent identity by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Marmoset, Elephant, Bovine, Rabbit, Horse, Pig, Opossum, Guinea pig (100%).
Immunogen Type
Synthetic peptide
Immunogen
MAOB / Monoamine Oxidase B antibody was raised against synthetic peptide C-HKARKLARLTKEE from an internal region of human MAOB (NP_000889.3). Percent identity by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Marmoset, Elephant, Bovine, Rabbit, Horse, Pig, Opossum, Guinea pig (100%); Mouse, Rat, Panda, Dog (92%); Bat (85%).
Antigen Modification
Internal
Applications Tested/Suitable for anti-MAOB antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-MAOB antibody
ELISA (1:32000), IHC-P (5 ug/ml), WB (1 - 3 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-MAOB antibody

Anti-MAOB antibody IHC of human brain. cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Goat Anti-MAOB Polyclonal Antibody – Cat# MBS242608

Western Blot (WB) of anti-MAOB antibody

Antibody (1 ug/ml) staining of Human Brain lysate (35 ug protein in RIPA buffer) with (B) and without (A) blocking with the immunizing peptide. Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-MAOB Polyclonal Antibody, Western Blot (WB) – Cat# MBS242608

Other Notes

Small volumes of anti-MAOB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MAOB. It may not necessarily be applicable to this product.

NCBI GI #
38202207
NCBI GeneID
4129
NCBI Accession #
NP_000889.3
UniProt Primary Accession #
P27338
UniProt Secondary Accession #
Q7Z6S2; B2R6R3; B7Z5H3; D3DWC3
UniProt Related Accession #
P27338
GenBank Nucleotide #
NM_000898.4
NCBI Official Full Name
amine oxidase
NCBI Official Synonym Full Names
monoamine oxidase B
NCBI Official Symbol
MAOB
UniProt Protein Name
Amine oxidase [flavin-containing] B
UniProt Synonym Protein Names
Monoamine oxidase type B; MAO-B
Protein Family
Amine oxidase
UniProt Gene Name
MAOB
UniProt Synonym Gene Names
MAO-B
UniProt Entry Name
AOFB_HUMAN
NCBI Protein Information
amine oxidase [flavin-containing] B; amine oxidase [flavin-containing] B; MAO-B; MAO, brain; MAO, platelet; tyramine oxidase; adrenalin oxidase; monoamine oxidase type B

NCBI Summary for MAOB

The protein encoded by this gene belongs to the flavin monoamine oxidase family. It is a enzyme located in the mitochondrial outer membrane. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous sysytem and peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine. [provided by RefSeq, Jul 2008]
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UniProt Comments for MAOB

MAOB: Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine. Belongs to the flavin monoamine oxidase family.

Protein type: Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - histidine; Mitochondrial; Amino Acid Metabolism - tyrosine; Oxidoreductase; Membrane protein, integral; EC 1.4.3.4; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Amino Acid Metabolism - glycine, serine and threonine

Chromosomal Location of Human Ortholog: Xp11.23

Cellular Component: mitochondrial envelope; mitochondrial outer membrane; mitochondrion; mitochondrial inner membrane; integral to membrane

Molecular Function: amine oxidase activity; protein homodimerization activity; FAD binding; electron carrier activity

Biological Process: response to drug; positive regulation of dopamine metabolic process; negative regulation of serotonin secretion; response to selenium ion; substantia nigra development; response to ethanol; dopamine catabolic process; response to toxin; xenobiotic metabolic process; response to lipopolysaccharide; hydrogen peroxide biosynthetic process; response to aluminum ion; response to corticosterone stimulus
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Research Articles on MAOB

1. Our results confirmed that SNPs in DRD4 and COMT, but not DBH or MAOB are associated with autism and ADHD in small, ethnically homogeneous groups of non-related male Caucasians.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MAOB antibody

 Reference Product  PubMed Publications
 COMT antibody  >30 publications with MAOB and COMT
 DBH antibody  >5 publications with MAOB and DBH
 DDC antibody  >5 publications with MAOB and DDC
 CYP2D6 antibody  >4 publications with MAOB and CYP2D6

Pathways associated with anti-MAOB antibody

 Products by Pathway  Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alpha-synuclein Signaling Pathway antibodies  Alpha-synuclein Signaling Pathway Diagram
 Amine Oxidase Reactions Pathway antibodies  Amine Oxidase Reactions Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Biogenic Amines Are Oxidatively Deaminated To Aldehydes By MAOA And MAOB Pathway antibodies  Biogenic Amines Are Oxidatively Deaminated To Aldehydes By MAOA And MAOB Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram

Diseases associated with anti-MAOB antibody

 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >67 publications with MAOB and Mental Disorders
 Movement Disorders Antibodies  >46 publications with MAOB and Movement Disorders
 Parkinsonian Disorders Antibodies  >42 publications with MAOB and Parkinsonian Disorders
 Parkinson Disease Antibodies  >40 publications with MAOB and Parkinson Disease
 Schizophrenia Antibodies  >15 publications with MAOB and Schizophrenia
 Autistic Disorder Antibodies  >6 publications with MAOB and Autistic Disorder
 Depressive Disorder Antibodies  >5 publications with MAOB and Depressive Disorder
 Bipolar Disorder Antibodies  >5 publications with MAOB and Bipolar Disorder
 Learning Disorders Antibodies  >4 publications with MAOB and Learning Disorders
 Cognition Disorders Antibodies  >3 publications with MAOB and Cognition Disorders

Organs/Tissues associated with anti-MAOB antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >64 publications with MAOB and Brain
 Nerve Antibodies  >14 publications with MAOB and Nerve
 Liver Antibodies  >9 publications with MAOB and Liver
 Eye Antibodies  >7 publications with MAOB and Eye
 Muscle Antibodies  >6 publications with MAOB and Muscle
 Adrenal Gland Antibodies  >5 publications with MAOB and Adrenal Gland
 Kidney Antibodies  >4 publications with MAOB and Kidney
 Pituitary Gland Antibodies  >2 publications with MAOB and Pituitary Gland
 Thyroid Antibodies  >2 publications with MAOB and Thyroid
 Skin Antibodies  >2 publications with MAOB and Skin
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