MYO10 Antibody – Rabbit Polyclonal

This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-10 (MYH10). Unconventional myosins contain the basic domains of conventional myosins and are further distinguished from class members by their tail domains. This gene functions as an actin-based molecular motor and plays a role in integration of F-actin and microtubule cytoskeletons during meiosis. [provided by RefSeq, Dec 2011]

MYO10: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. May play a role in neurite outgrowth and axon guidance. Plays a role in formation of the podosome belt in osteoclasts.

Protein type: Motor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 5p15.1-p14.3

Cellular Component: ruffle; filopodium membrane; filopodium tip; neuron projection; cell soma; lamellipodium; cytoplasm; nucleolus; plasma membrane; cell cortex; cytosol; myosin complex

Molecular Function: actin filament binding; calmodulin binding; protein binding; phosphatidylinositol-3,4,5-triphosphate binding; spectrin binding; plus-end directed microfilament motor activity; actin-dependent ATPase activity; ATP binding

Biological Process: axon guidance; regulation of cell shape; metabolic process; positive regulation of cell-cell adhesion; innate immune response; regulation of filopodium formation; cytoskeleton-dependent intracellular transport