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GCNT3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS242931

GCNT3 is a Beta-1, 6-N-Acetylglucosaminyltranscerase that catalyzes O-glycan branch formation of the core 2 and core 4 type. The expression of core 2 O-glycans has been correlated with cell differentiation processes and cancer. More details

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Product Overview

Product Name
GCNT3, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal (IgG) to Human GCNT3
Product Gene Name
anti-GCNT3 antibody
Product Synonym Names
Anti-GCNT3 Antibody (aa226-275) IHC-plus; GCNT3; Beta1;6GlcNAc-transferase; C24GNT; C2/4GnT; C2GnT-mucin type; C2GNTM; C2GnT-M; C2GNT2; GNTM; HC2GnT-M; Human GCNT3
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
GCNT3 Antibody detects endogenous levels of total GCNT3 protein.
Preparation and Storage
Store at -20 degree C for up to one year.
Molecular Weight
50,864 Da
OMIM
606836
3D Structure
ModBase 3D Structure for O95395
Target Species
Human
Immunogen Description
Synthetic peptide from human GCNT3 (aa226-275).
Immunogen
GCNT3 antibody was raised against synthetic peptide from human GCNT3 (aa226-275).
Antigen Modification
aa226-275
Applications Tested/Suitable for anti-GCNT3 antibody
Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), ELISA (EIA)
Application Notes for anti-GCNT3 antibody
ELISA (1:20000), IF (1:100 - 1:500), IHC-P (10 ug/ml)

Immunohistochemistry (IHC) of anti-GCNT3 antibody

Anti-GCNT3 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.
Rabbit Anti-GCNT3 Polyclonal Antibody – Cat# MBS242931

Immunofluorescence (IF) of anti-GCNT3 antibody

Immunofluorescence of A549 cells, using GCNT3 Antibody. The picture on the right is treated with the synthesized peptide.
Rabbit Anti-GCNT3 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS242931

Other Notes

Small volumes of anti-GCNT3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GCNT3 purchase

MBS242931 is an antibody targeting GCNT3. Also known as Rabbit Polyclonal (IgG) to Human GCNT3. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GCNT3. It may not necessarily be applicable to this product.

NCBI GI #
4758422
NCBI GeneID
9245
NCBI Accession #
NP_004742.1
UniProt Primary Accession #
O95395
UniProt Related Accession #
O95395
GenBank Nucleotide #
NM_004751.2
NCBI Official Full Name
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3
NCBI Official Synonym Full Names
glucosaminyl (N-acetyl) transferase 3, mucin type
NCBI Official Symbol
GCNT3
NCBI Official Synonym Symbols
GNTM; C24GNT; C2GNT2; C2GNTM; C2/4GnT
UniProt Protein Name
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3
UniProt Synonym Protein Names
C2GnT-mucin type; C2GnT-M; hC2GnT-M; Core 2/core 4 beta-1,6-N-acetylglucosaminyltransferase; C2/4GnT
Protein Family
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
UniProt Gene Name
GCNT3
UniProt Synonym Gene Names
C2GnT-M; hC2GnT-M; C2/4GnT
UniProt Entry Name
GCNT3_HUMAN
NCBI Protein Information
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3; hC2GnT-M; C2GnT-mucin type; beta1,6GlcNAc-transferase; beta1,6-N-acetylglucosaminyltransferase-M; core 2/core 4 beta-1,6-N-acetylglucosaminyltransferase; mucus-type core 2 beta-1,6-N-acetylglucosaminyltransferase

NCBI Summary for GCNT3

This gene encodes a member of the N-acetylglucosaminyltransferase family. The encoded protein is a beta-6-N-acetylglucosamine-transferase that catalyzes the formation of core 2 and core 4 O-glycans on mucin-type glycoproteins.[provided by RefSeq, Apr 2009]

UniProt Comments for GCNT3

GCNT3: Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Has also I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development. Belongs to the glycosyltransferase 14 family.

Protein type: EC 2.4.1.150; Membrane protein, integral; EC 2.4.1.102; Transferase; Glycan Metabolism - O-glycan biosynthesis

Chromosomal Location of Human Ortholog: 15q21.3

Cellular Component: Golgi membrane; membrane; integral to membrane

Molecular Function: beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity; N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity; acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity

Biological Process: protein amino acid O-linked glycosylation; tissue morphogenesis; cellular protein metabolic process; O-glycan processing; immunoglobulin production in mucosal tissue; carbohydrate metabolic process; post-translational protein modification; intestinal absorption
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Research Articles on GCNT3

1. Golgi fragmentation is accompanied by the increased association of NMIIA with C2GnT-M and its degradation by proteasomes.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GCNT3 antibody

 Reference Product  PubMed Publications
 MUC6 antibody  >2 publications with GCNT3 and MUC6
 MUC2 antibody  >1 publications with GCNT3 and MUC2
 MUC5B antibody  >1 publications with GCNT3 and MUC5B

Pathways associated with anti-GCNT3 antibody

 Products by Pathway  Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Mucin Type O-Glycan Biosynthesis Pathway antibodies  Mucin Type O-Glycan Biosynthesis Pathway Diagram
 Mucin Type O-Glycan Biosynthesis Pathway antibodies  Mucin Type O-Glycan Biosynthesis Pathway Diagram
 O-glycan Biosynthesis, Mucin Type Core Pathway antibodies  O-glycan Biosynthesis, Mucin Type Core Pathway Diagram
 O-glycan Biosynthesis, Mucin Type Core Pathway antibodies  O-glycan Biosynthesis, Mucin Type Core Pathway Diagram
 O-linked Glycosylation Pathway antibodies  O-linked Glycosylation Pathway Diagram
 O-linked Glycosylation Of Mucins Pathway antibodies  O-linked Glycosylation Of Mucins Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
 Mucin Core 1 And Core 2 O-glycosylation Pathway antibodies  Mucin Core 1 And Core 2 O-glycosylation Pathway Diagram

Diseases associated with anti-GCNT3 antibody

 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >2 publications with GCNT3 and Immune System Diseases
 Hyperplasia Antibodies  >2 publications with GCNT3 and Hyperplasia
 Respiratory Tract Diseases Antibodies  >1 publications with GCNT3 and Respiratory Tract Diseases
 Lung Diseases Antibodies  >1 publications with GCNT3 and Lung Diseases
 Carcinoma Antibodies  >1 publications with GCNT3 and Carcinoma
 Carcinoma, Hepatocellular Antibodies  >1 publications with GCNT3 and Carcinoma, Hepatocellular

Organs/Tissues associated with anti-GCNT3 antibody

 Organ/Tissue Name  Pubmed Publications
 Intestine Antibodies  >3 publications with GCNT3 and Intestine
 Prostate Antibodies  >2 publications with GCNT3 and Prostate
 Blood Antibodies  >1 publications with GCNT3 and Blood
 Eye Antibodies  >1 publications with GCNT3 and Eye
 Lung Antibodies  >1 publications with GCNT3 and Lung
 Muscle Antibodies  >1 publications with GCNT3 and Muscle
 Liver Antibodies  >1 publications with GCNT3 and Liver
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