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NR1I3 cDNA Clone – Nuclear Receptor Subfamily 1, Group I, Member 3 (Human)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1274232

MBS1274232 is a cDNA clone targeting NR1I3. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
NR1I3, cDNA Clone
Full Product Name
NR1I3 cDNA Clone
Product Gene Name
NR1I3 cdna clone
Sequence
atggccagta gggaagatga gctgaggaac tgtgtggtat gtggggacca agccacaggc taccacttta atgcgctgac ttgtgagggc tgcaagggtt tcttcaggag aacagtcagc aaaagcattg gtcccacctg cccctttgct ggaagctgtg aagtcagcaa gactcagagg cgccactgcc cagcctgcag gttgcagaag tgcttagatg ctggcatgag gaaagacatg atactgtcgg cagaagccct ggcattgcgg cgagcaaagc aggcccagcg gcgggcacag caaacacctg tgcaactgag taaggagcaa gaagagctga tccggacact cctgggggcc cacacccgcc acatgggcac catgtttgaa cagtttgtgc agtttaggcc tccagctcat ctgttcatcc atcaccagcc cttgcccacc ctggcccctg tgctgcctct ggtcacacac ttcgcagaca tcaacacttt catggtactg caagtcatca agtttactaa ggacctgcct gtcttccgtt ccctgcccat tgaagaccag atctcccttc tcaagggagc agctgtggaa atctgtcaca tcgtactcaa taccactttc tgtctccaaa cacaaaactt cctctgcggg cctcttcgct acacaattga agatggagcc cgtgtatctc ccacagtggg gttccaggta gagtttttgg agttgctctt tcacttccat ggaacactac gaaaactgca gctccaagag cctgagtatg tgctcttggc tgccatggcc ctcttctctc ctgaccgacc tggagttacc cagagagatg agattgatca gctgcaagag gagatggcac tgactctgca aagctacatc aagggccagc agcgaaggcc ccgggatcgg tttctgtatg cgaagttgct aggcctgctg gctgagctcc ggagcattaa tgaggcctac gggtaccaaa tccagcacat ccagggcctg tctgccatga tgccgctgct ccaggagatc tgcagctga
Molecular Weight
30,262 Da
OMIM
603881
Vector
pENTR223.1
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of NR1I3 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for NR1I3. It may not necessarily be applicable to this product.

NCBI GI #
46854439
NCBI GeneID
9970
NCBI Accession #
BC069626
UniProt Secondary Accession #
Q0VAC9; Q4U0F0; E9PB75; E9PC13; E9PDU3; E9PGH6; E9PH10; E9PHC8; E9PHN4; F1D8Q0; F1D8Q1
UniProt Related Accession #
Q14994
NCBI Official Full Name
Homo sapiens nuclear receptor subfamily 1, group I, member 3, mRNA
NCBI Official Synonym Full Names
nuclear receptor subfamily 1 group I member 3
NCBI Official Symbol
NR1I3
NCBI Official Synonym Symbols
CAR; CAR1; MB67
UniProt Protein Name
Nuclear receptor subfamily 1 group I member 3
UniProt Synonym Protein Names
Constitutive activator of retinoid response; Constitutive active response; Constitutive androstane receptor; CAR; Orphan nuclear receptor MB67
Protein Family
Nuclear receptor subfamily
UniProt Gene Name
NR1I3
UniProt Synonym Gene Names
CAR; Constitutive active response; CAR
UniProt Entry Name
NR1I3_HUMAN
NCBI Protein Information
nuclear receptor subfamily 1 group I member 3

NCBI Summary for NR1I3

This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for NR1I3

NR1I3: Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element. Interacts with ECT2. Heterodimer of NR1I3 and RXR. Interacts with PSMC4. Directly interacts with DNAJC7. The DNAJC7-NR1I3 complex may also include HSP90. By dexamethasone. Predominantly expressed in liver. Belongs to the nuclear hormone receptor family. NR1 subfamily. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor; DNA-binding

Chromosomal Location of Human Ortholog: 1q23.3

Cellular Component: cytoplasm; nucleoplasm; nucleus

Molecular Function: androgen receptor activity; DNA binding; ligand-dependent nuclear receptor activity; transcription coactivator activity; transcription factor activity

Biological Process: positive regulation of transcription from RNA polymerase II promoter; signal transduction; transcription initiation from RNA polymerase II promoter
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Research Articles on NR1I3

1. These results reveal both novel and known targets of hCAR and support the role of hCAR in maintaining the homeostasis of metabolism and cell proliferation in the liver.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with NR1I3 cdna clone

 Products by Pathway  Pathway Diagram
 Drug Induction Of Bile Acid Pathway antibodies  Drug Induction Of Bile Acid Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Glucocorticoid Receptor Regulatory Network Pathway antibodies  Glucocorticoid Receptor Regulatory Network Pathway Diagram
 Nuclear Receptor Transcription Pathway antibodies  Nuclear Receptor Transcription Pathway Diagram
 Nuclear Receptors Pathway antibodies  Nuclear Receptors Pathway Diagram
 Nuclear Receptors In Lipid Metabolism And Toxicity Pathway antibodies  Nuclear Receptors In Lipid Metabolism And Toxicity Pathway Diagram

Diseases associated with NR1I3 cdna clone

 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >14 publications with NR1I3 and Liver Diseases
 Neoplasms Antibodies  >13 publications with NR1I3 and Neoplasms
 Drug Toxicity Antibodies  >10 publications with NR1I3 and Drug Toxicity
 Carcinoma, Hepatocellular Antibodies  >8 publications with NR1I3 and Carcinoma, Hepatocellular
 Obesity Antibodies  >7 publications with NR1I3 and Obesity
 Liver Neoplasms Antibodies  >7 publications with NR1I3 and Liver Neoplasms
 Fatty Liver Antibodies  >6 publications with NR1I3 and Fatty Liver
 Cholestasis Antibodies  >5 publications with NR1I3 and Cholestasis
 Inflammation Antibodies  >5 publications with NR1I3 and Inflammation
 Diabetes Mellitus Antibodies  >4 publications with NR1I3 and Diabetes Mellitus

Organs/Tissues associated with NR1I3 cdna clone

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >63 publications with NR1I3 and Liver
 Brain Antibodies  >6 publications with NR1I3 and Brain
 Kidney Antibodies  >5 publications with NR1I3 and Kidney
 Muscle Antibodies  >1 publications with NR1I3 and Muscle
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