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NOD3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS242957

MBS242957 is an antibody targeting NOD3. Also known as Rabbit Polyclonal to Human NOD3 / NLRC3. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

$650 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
NOD3 / NLRC3, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human NOD3 / NLRC3
Product Gene Name
Product Synonym Gene Name
NLRC3
Product Synonym Names
Anti-NOD3 / NLRC3 Antibody (Internal) IHC-plus; NLRC3; CARD15-like protein; Caterpiller 16.2; Caterpiller protein 16.2; NOD-like receptor C3; NOD3; Protein NLRC3; CLR16.2; Human NOD3; NLRC3
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
PBS, 0.02% sodium azide
Purity/Purification
Peptide Columns Affinity Chromatography
Concentration
1 mg/ml (lot specific)
Specificity
Human NLRC3
Preparation and Storage
Store at 4°C for up 3 months. Store at -20°C for up to 1 year. Avoid freeze/thaw cycles.
3D Structure
ModBase 3D Structure for Q7RTR2
Immunogen Description
An 18 amino acid peptide near the center of human NOD3.
Usage
NOD3 antibody can be used for detection of NOD3 by Western blot at 1 - 2 ug/mL. Antibody can also be used for immunofluorescence starting at 20 ug/mL. For immunofluorescence start at 20 ug/mL. Antibody validated: Western Blot in mouse samples and Immunofluorescence in human samples. All other applications and species not yet tested. Western Blot:
Immunogen Type
Synthetic peptide
Immunogen
NOD3 / NLRC3 antibody was raised against an 18 AA synthetic peptide near the center of human NOD3. The immunogen is located within aa 630-680 of NOD3
Immunogen Species
NOD3 / NLRC3 antibody was raised againts Human
Applications Tested/Suitable for anti-NOD3 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA), Immunofluorescence (IF)
Application Notes for anti-NOD3 antibody
IHC - Paraffin (5 ug/ml)
Western blot (1 - 2 ug/ml)

Immunohistochemistry (IHC) of anti-NOD3 antibody

Anti-NLRC3 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-NOD3 Polyclonal Antibody – Cat# MBS242957

Immunohistochemistry (IHC) of anti-NOD3 antibody

Anti-NLRC3 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-NOD3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS242957

Immunofluorescence (IF) of anti-NOD3 antibody

Immunofluorescence of NOD3 in Jurkat cells with NOD3 antibody at 20 ug/ml.
Rabbit Anti-NOD3 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS242957

Other Notes

Small volumes of anti-NOD3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for NOD3. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
protein NLRC3
NCBI Official Synonym Full Names
NLR family, CARD domain containing 3
NCBI Official Symbol
NLRC3
NCBI Official Synonym Symbols
NOD3; CLR16.2
UniProt Protein Name
Protein NLRC3
UniProt Synonym Protein Names
CARD15-like protein; Caterpiller protein 16.2; CLR16.2; Nucleotide-binding oligomerization domain protein 3
UniProt Gene Name
NLRC3
UniProt Synonym Gene Names
NOD3; CLR16.2
UniProt Entry Name
NLRC3_HUMAN
NCBI Protein Information
protein NLRC3; CARD15-like protein; NOD-like receptor C3; caterpiller protein 16.2; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 3

NCBI Summary for NOD3

This gene encodes a NOD-like receptor family member. The encoded protein is a cytosolic regulator of innate immunity. This protein directly interacts with stimulator of interferon genes (STING), to prevent its proper trafficking, resulting in disruption of STING-dependent activation of the innate immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
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UniProt Comments for NOD3

NLRC3: May modulate T-cell activation. Decreases the transcription of genes that are normally up-regulated after T-cell stimulation. Delays degradation of NFKBIA/IKBA. Belongs to the NLRP family. 4 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: cytoplasm

Molecular Function: ATP binding

Biological Process: I-kappaB kinase/NF-kappaB cascade; T cell activation; regulation of protein ubiquitination; inhibition of NF-kappaB transcription factor; response to lipopolysaccharide; negative regulation of I-kappaB kinase/NF-kappaB cascade
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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