Rabbit Anti-RORC Polyclonal Antibody – Cat# MBS243156

Anti-ROR Gamma antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

RORC Antibody – Rabbit Polyclonal

Name: RORC Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS243156
Price: 630 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS243156

ROR Gamma (RORC), an NR1 Thyroid Hormone-Like receptor, has been shown to affect thymopoiesis, bone metabolism, T-cell apoptosis, and lymphoid organogenesis. ROR gamma has been shown to promote thymocyte survival by activating the expression of the… More details

$630 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

RORC / ROR Gamma, Polyclonal Antibody

Full Product Name

Rabbit Polyclonal to Human RORC / ROR Gamma

Product Gene Name

anti-RORC antibody

Product Synonym Names

Anti-RORC / ROR Gamma Antibody (Ligand-binding Domain) IHC-plus; RORC; Nuclear receptor ROR-gamma; Nuclear receptor RZR-gamma; RAR-related orphan receptor C; RORG; RORgamma; TOR; ROR Gamma; RZRG; NR1F3; RZR-GAMMA; Human RORC; ROR Gamma

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Gibbon, Chimpanzee, Gorilla, Human, Monkey, Orangutan
Predicted Reactivity: Mouse, Rat, Bat, Hamster (at least 90% immunogen sequence identity)

Form/Format

PBS, 0.1% sodium azide.

Purity/Purification

Immunoaffinity Purified

Concentration

1 mg/ml (lot specific)

Specificity

Human ROR Gamma. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Preparation and Storage

Long term: -70 degree C; Short term: +4 degree C

Molecular Weight

55,813 Da

OMIM

602943

3D Structure

ModBase 3D Structure for P51449

Target Species

Human

Immunogen Description

Synthetic 19 amino acid peptide from ligand-binding domain of human ROR Gamma. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Monkey, Marmoset, Tamarin, Elephant (100%).

Immunogen Type

Synthetic peptide

Immunogen

RORC / ROR Gamma antibody was raised against synthetic 19 amino acid peptide from ligand-binding domain of human ROR Gamma. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Monkey, Marmoset, Tamarin, Elephant (100%); Mouse, Rat, Hamster, Panda, Bat (95%); Bovine, Dog, Rabbit, Horse, Opossum (89%).

Antigen Modification

Ligand-binding Domain

Product Categories/Family for anti-RORC antibody

Family: NHR; Subfamily: NR1 Thyroid hormone-like

Applications Tested/Suitable for anti-RORC antibody

Immunohistochemistry (IHC - Paraffin)

Application Notes for anti-RORC antibody

IHC-P (22 ug/ml)

Other Notes

Small volumes of anti-RORC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RORC purchase

MBS243156 is an antibody targeting RORC. Also known as Rabbit Polyclonal to Human RORC / ROR Gamma. Reactive in Gibbon, Chimpanzee, Gorilla, Human, Monkey, Orangutan
Predicted Reactivity: Mouse, Rat, Bat, Hamster (at least 90% immunogen sequence identity). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for RORC. It may not necessarily be applicable to this product.

NCBI GI #

19743909

NCBI GeneID

6097

NCBI Accession #

NP_005051.2

UniProt Primary Accession #

P51449

UniProt Secondary Accession #

Q5SZR9; Q8N5V7; Q8NCY8

UniProt Related Accession #

P51449

GenBank Nucleotide #

NM_005060.3

NCBI Official Full Name

nuclear receptor ROR-gamma isoform a

NCBI Official Synonym Full Names

RAR-related orphan receptor C

NCBI Official Symbol

RORC

NCBI Official Synonym Symbols

TOR; RORG; RZRG; NR1F3; RZR-GAMMA

UniProt Protein Name

Nuclear receptor ROR-gamma

UniProt Synonym Protein Names

Nuclear receptor RZR-gamma; Nuclear receptor subfamily 1 group F member 3; RAR-related orphan receptor C; Retinoid-related orphan receptor-gamma

Protein Family

Nuclear receptor

UniProt Gene Name

RORC

UniProt Synonym Gene Names

NR1F3; RORG; RZRG

UniProt Entry Name

RORG_HUMAN

NCBI Protein Information

nuclear receptor ROR-gamma; nuclear receptor RZR-gamma; retinoic acid-binding receptor gamma; retinoid-related orphan receptor gamma; RAR-related orphan receptor C, isoform a; RAR-related orphan nuclear receptor variant 2; nuclear receptor subfamily 1 group F member 3

NCBI Summary for RORC

The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

UniProt Comments for RORC

RORC: Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock. Belongs to the nuclear hormone receptor family. NR1 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; DNA-binding; Nuclear receptor

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: nucleoplasm; nucleus

Molecular Function: ligand-dependent nuclear receptor activity; protein binding; DNA binding; zinc ion binding; sequence-specific DNA binding; oxysterol binding; steroid hormone receptor activity; transcription factor activity

Biological Process: Peyer's patch development; transcription initiation from RNA polymerase II promoter; intracellular receptor-mediated signaling pathway; regulation of fat cell differentiation; T-helper cell differentiation; positive regulation of transcription, DNA-dependent; T cell differentiation in the thymus; positive regulation of circadian rhythm; regulation of gamma-delta T cell differentiation; lymph node development; protein amino acid phosphorylation; xenobiotic metabolic process; regulation of steroid metabolic process; gene expression; steroid hormone mediated signaling; circadian regulation of gene expression

Research Articles on RORC

1. Expression of RORC in nasal epithelial cells was higher in nasal polyps compared to control mucosa.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RORC antibody

Reference Product	PubMed Publications
RORA antibody	>21 publications with RORC and RORA
RORB antibody	>5 publications with RORC and RORB
NR1D1 antibody	>5 publications with RORC and NR1D1
NR1D2 antibody	>3 publications with RORC and NR1D2
RXRA antibody	>1 publications with RORC and RXRA

Pathways associated with anti-RORC antibody

Products by Pathway	Pathway Diagram
Circadian Rhythm Pathway antibodies	Circadian Rhythm Pathway Diagram
Circadian Rhythm Pathway antibodies	Circadian Rhythm Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
Generic Transcription Pathway antibodies	Generic Transcription Pathway Diagram
Inflammatory Bowel Disease (IBD) Pathway antibodies	Inflammatory Bowel Disease (IBD) Pathway Diagram
Inflammatory Bowel Disease (IBD) Pathway antibodies	Inflammatory Bowel Disease (IBD) Pathway Diagram
Nuclear Receptor Transcription Pathway antibodies	Nuclear Receptor Transcription Pathway Diagram
Nuclear Receptors Pathway antibodies	Nuclear Receptors Pathway Diagram

Diseases associated with anti-RORC antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>123 publications with RORC and Inflammation
Disease Models, Animal Antibodies	>45 publications with RORC and Disease Models, Animal
Nervous System Diseases Antibodies	>41 publications with RORC and Nervous System Diseases
Brain Diseases Antibodies	>29 publications with RORC and Brain Diseases
Necrosis Antibodies	>24 publications with RORC and Necrosis
Cardiovascular Diseases Antibodies	>19 publications with RORC and Cardiovascular Diseases
Liver Diseases Antibodies	>10 publications with RORC and Liver Diseases
Atherosclerosis Antibodies	>7 publications with RORC and Atherosclerosis
Kidney Diseases Antibodies	>5 publications with RORC and Kidney Diseases
Cell Transformation, Neoplastic Antibodies	>4 publications with RORC and Cell Transformation, Neoplastic

Organs/Tissues associated with anti-RORC antibody

Organ/Tissue Name	Pubmed Publications
Thyroid Antibodies	>161 publications with RORC and Thyroid
Intestine Antibodies	>42 publications with RORC and Intestine
Thymus Antibodies	>40 publications with RORC and Thymus
Liver Antibodies	>34 publications with RORC and Liver
Lymph Node Antibodies	>34 publications with RORC and Lymph Node
Lung Antibodies	>24 publications with RORC and Lung
Bone Antibodies	>19 publications with RORC and Bone
Muscle Antibodies	>12 publications with RORC and Muscle
Pancreas Antibodies	>8 publications with RORC and Pancreas
Kidney Antibodies	>7 publications with RORC and Kidney