LGR6 Antibody – Rabbit Polyclonal

This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

LGR6: a leucine-rich repeat-containing G-protein-coupled receptor. Receptor for R-spondins, potent stimulators of adult stem cell proliferation. A marker of adult stem cells. A Wnt receptor component that enhances Wnt signaling by soluble R-spondin proteins. A marker of a multipotent population of skin stem cells. Three isoforms of the human protein are produced by alternative splicing.

Protein type: GPCR, family 1; Membrane protein, integral; Receptor, GPCR; Tumor suppressor; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: nucleoplasm; integral to plasma membrane; cytoplasm; plasma membrane; trans-Golgi network membrane; vesicle

Molecular Function: G-protein coupled receptor activity; protein binding; transmembrane receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; Wnt receptor signaling pathway; positive regulation of Wnt receptor signaling pathway; positive regulation of cell migration