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MRNP41 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS244177

MBS244177 is an antibody targeting MRNP41. Also known as Goat Polyclonal to Human MRNP41 / RAE1. Reactive in Bat, Gibbon, Bovine, Chicken, Dog, Xenopus, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Orangutan, Pig, Rabbit, Rat, Zebrafish. Host: Goat. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
MRNP41 / RAE1, Polyclonal Antibody
Full Product Name
Goat Polyclonal to Human MRNP41 / RAE1
Product Gene Name
Product Synonym Gene Name
RAE1
Product Synonym Names
Anti-MRNP41 / RAE1 Antibody (C-Terminus) IHC-plus; RAE1; DJ481F12.3; DJ800J21.1; Mnrp41; MRNA export factor; MRNA-binding protein; 41-kD; Rae1 protein homolog; MIG14; Migration-inducing gene 14; MRNA export protein; MRNP41; Human MRNP41; RAE1
Clonality
Polyclonal
Host
Goat
Species Reactivity
Bat, Gibbon, Bovine, Chicken, Dog, Xenopus, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Orangutan, Pig, Rabbit, Rat, Zebrafish
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
Human RAE1. NP_003601and NP_001015885 represent identical proteins.
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
40,968 Da
OMIM
603343
3D Structure
ModBase 3D Structure for P78406
Target Species
Human
Immunogen Description
Synthetic peptide C-NAAEELKPRNKK from the C-terminus of human RAE1 (NP_003601.1; NP_001015885.1).
Immunogen Type
Synthetic peptide
Immunogen
MRNP41 / RAE1 antibody was raised against synthetic peptide C-NAAEELKPRNKK from the C-terminus of human RAE1 (NP_003601.1; NP_001015885.1). Percent identity by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Panda, Dog, Bat, Bovine, Horse, Rabbit, Pig, Opossum, Turkey, Chicken, Platypus, Xenopus, Seabass, Zebrafish (100%); Salmon, Stickleback (92%).
Antigen Modification
C-Terminus
Applications Tested/Suitable for anti-MRNP41 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-MRNP41 antibody
ELISA (1:64000), IHC-P (3.75 ug/ml), WB (0.03 - 0.1 ug/ml)

Immunohistochemistry (IHC) of anti-MRNP41 antibody

Anti-RAE1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
Goat Anti-MRNP41 Polyclonal Antibody – Cat# MBS244177

Immunohistochemistry (IHC) of anti-MRNP41 antibody

Anti-RAE1 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
Goat Anti-MRNP41 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS244177

Western Blot (WB) of anti-MRNP41 antibody

Antibody staining (0.03 ug/ml) of HepG2 lysate (RIPA buffer, 30 ug total protein per lane). Primary incubated for 1 hour. Detected by Western blot of chemiluminescence.
Goat Anti-MRNP41 Polyclonal Antibody, Western Blot (WB) – Cat# MBS244177

Other Notes

Small volumes of anti-MRNP41 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MRNP41. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
mRNA export factor
NCBI Official Synonym Full Names
ribonucleic acid export 1
NCBI Official Symbol
RAE1
NCBI Official Synonym Symbols
MIG14; MRNP41; Mnrp41; dJ481F12.3; dJ800J21.1
UniProt Protein Name
mRNA export factor
UniProt Synonym Protein Names
Rae1 protein homolog; mRNA-associated protein mrnp 41
UniProt Gene Name
RAE1
UniProt Synonym Gene Names
MRNP41
UniProt Entry Name
RAE1L_HUMAN
NCBI Protein Information
mRNA export factor; mRNA export protein; rae1 protein homolog; RAE1 RNA export 1 homolog; migration-inducing gene 14; mRNA-binding protein, 41-kD; mRNA-associated protein MRNP 41; homolog of yeast Rae1 (Bharathi) mRNA-associated protein of 41 kDa (Kraemer)

NCBI Summary for MRNP41

Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result in accumulation of poly(A)-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA export. The protein encoded by this gene is a homolog of yeast Rae1. It contains four WD40 motifs, and has been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the cytoplasm. This gene is thought to be involved in nucleocytoplasmic transport, and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for MRNP41

RAE1: Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Belongs to the WD repeat rae1 family.

Protein type: Motility/polarity/chemotaxis; RNA-binding

Chromosomal Location of Human Ortholog: 20q13.31

Cellular Component: nuclear outer membrane; cytoskeleton; cytoplasm; nucleolus; nuclear pore; nuclear envelope; nucleus

Molecular Function: RNA binding; microtubule binding

Biological Process: mRNA export from nucleus; viral reproduction; hexose transport; cytokine and chemokine mediated signaling pathway; carbohydrate metabolic process; mitotic nuclear envelope disassembly; pathogenesis; viral transcription; gene expression; mitotic cell cycle; glucose transport; viral infectious cycle; transmembrane transport
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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