Human WWP2 cDNA Clone Expression Plasmid – Cat# MBS1274763

WWP2 cDNA Clone – Ww Domain Containing E3 Ubiquitin Protein Ligase 2 (Human)

Name: WWP2 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1274763
Price: 235 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1274763

MBS1274763 is a cDNA clone targeting WWP2. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

WWP2, cDNA Clone

Full Product Name

WWP2 cDNA Clone

Product Gene Name

WWP2 cdna clone

Sequence

atggcatctg ccagctctag ccgggcagga gtggccctgc cttttgagaa gtctcagctc actttgaaag tggtgtccgc aaagcccaag gtgcataatc gtcaacctcg aattaactcc tacgtggagg tggcggtgga tggactcccc agtgagacca agaagactgg gaagcgcatt gggagctctg agcttctctg gaatgagatc atcattttga atgtcacggc acagagtcat ttagatttaa aggtctggag ctgccatacc ttgagaaatg aactgctagg caccgcatct gtcaacctct ccaacgtctt gaagaacaat gggggcaaaa tggagaacat gcagctgacc ctgaacctgc agacggagaa caaaggcagc gttgtctcag gcggagagct gacaattttc ctggacgggc caactgttga tctgggaaat gtgcctaatg gcagtgccct gacagatgga tcacagctgc cttcgagaga ctccagtgga acagcagtag ctccagagaa ccggcaccag ccccccagca caaactgctt tggtggaaga tcccggacgc acagacattc gggtgcttca gccagaacaa ccccagcaac cggcgagcaa agccccggtg ctcggagccg gcaccgccag cccgtcaaga actcaggcca cagtggcttg gccaatggca cagtgaatga tgaacccaca acagccactg atcccgaaga accttccgtt gttggtgtga cgtccccacc tgctgcaccc ttgagtgtga ccccgaatcc caacacgact tctctccctg ccccagccac accggctgaa ggagaggaac ccagcacttc gggtacacag cagctcccag cggctgccca ggcccccgac gctctgcctg ctggatggga acagcgagag ctgcccaacg gacgtgtcta ttatgttgac cacaatacca agaccaccac ctgggagcgg ccccttcctc caggctggga aaaacgcaca gatccccgag gcaggtttta ctatgtggat cacaatactc ggaccaccac ctggcagcgt ccgaccgcgg agtacgtgcg caactatgag cagtggcagt cgcagcggaa tcagctccag ggggccatgc agcacttcag ccaaagattc ctctaccagt cttcgagtgc ttcgactgac catgatcccc tgggccccct ccctcctggc tgggagaaaa gacaggacaa tggacgggtg tattacgtga accataacac tcgcacgacc cagtgggagg atccccggac ccaggggatg atccaggaac cagctctgcc cccaggatgg gagatgaaat acaccagcga gggggtgcga tactttgtgg accacaatac ccgcaccacc acctttaagg atcctcgccc ggggtttgag tcggggacga agcaaggttc ccctggtgct tatgaccgca gttttcggtg gaagtatcac cagttccgtt tcctctgcca ttcaaatgcc ctacctagcc acgtgaagat cagcgtttcc aggcagacgc ttttcgaaga ttccttccaa cagatcatga acatgaaacc ctatgacctg cgccgccggc tctacatcat catgcgtggc gaggagggcc tggactatgg gggcatcgcc agagagtggt ttttcctcct gtctcacgag gtgctcaacc ctatgtattg tttatttgaa tatgccggaa agaacaatta ctgcctgcag atcaaccccg cctcctccat caacccggac cacctcacct actttcgctt tataggcaga ttcatcgcca tggcgctgta ccatggaaag ttcatcgaca cgggcttcac cctccctttc tacaagcgga tgctcaataa gagaccaacc ctgaaagacc tggagtccat tgaccctgag ttctacaact ccattgtctg gatcaaagag aacaacctgg aagaatgtgg cctggagctg tacttcatcc aggacatgga gatactgggc aaggtgacga cccacgagct gaaggagggc ggcgagagca tccgggtcac ggaggagaac aaggaagagt acatcatgct gctgactgac tggcgtttca cccgaggcgt ggaagagcag accaaagcct tcctggatgg cttcaacgag gtggccccgc tggagtggct gcgctacttt gacgagaaag agctggagct gatgctgtgc ggcatgcagg agatagacat gagcgactgg cagaagagca ccatctaccg gcactacacc aagaacagca agcagatcca gtggttctgg caggtggtga aggagatgga caacgagaag aggatccggc tgctgcagtt tgtcaccggt acctgccgcc tgcccgtcgg gggatttgcc gaactcatcg gtagcaacgg accacagaag ttttgcattg acaaagttgg caaggaaacc tggctgccca gaagccacac ctgcttcaac cgtctggatc ttccacccta caagagctac gaacagctga gagagaagct gctgtatgcc attgaggaga ccgagggctt tggacaggag taa

Molecular Weight

35,248 Da

OMIM

602308

Vector

pENTR223.1

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of WWP2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for WWP2. It may not necessarily be applicable to this product.

NCBI GI #

15489059

NCBI GeneID

11060

NCBI Accession #

BC013645

UniProt Secondary Accession #

Q6ZTQ5; Q96CZ2; Q9BWN6; A6NEP1; B2R706; B4DTL5; F5H213; H3BRF3; I3RSG8

UniProt Related Accession #

O00308

NCBI Official Full Name

Homo sapiens WW domain containing E3 ubiquitin protein ligase 2, mRNA

NCBI Official Synonym Full Names

WW domain containing E3 ubiquitin protein ligase 2

NCBI Official Symbol

WWP2

NCBI Official Synonym Symbols

AIP2; WWp2-like

UniProt Protein Name

NEDD4-like E3 ubiquitin-protein ligase WWP2

UniProt Synonym Protein Names

Atrophin-1-interacting protein 2; AIP2; WW domain-containing protein 2

Protein Family

NEDD4-like E3 ubiquitin-protein ligase

UniProt Gene Name

WWP2

UniProt Synonym Gene Names

AIP2

UniProt Entry Name

WWP2_HUMAN

NCBI Protein Information

NEDD4-like E3 ubiquitin-protein ligase WWP2

NCBI Summary for WWP2

This gene encodes a member of the Nedd4 family of E3 ligases, which play an important role in protein ubiquitination. The encoded protein contains four WW domains and may play a role in multiple processes including chondrogenesis and the regulation of oncogenic signaling pathways via interactions with Smad proteins and the tumor suppressor PTEN. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 10. [provided by RefSeq, Jul 2012]

UniProt Comments for WWP2

WWP2: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation- induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation.

Protein type: Ubiquitin conjugating system; EC 6.3.2.-; EC 6.3.2.19; Ubiquitin ligase; Ligase

Chromosomal Location of Human Ortholog: 16q22.1

Cellular Component: cytoplasm; membrane; nucleus; ubiquitin ligase complex

Molecular Function: protein binding; transcription factor binding; ubiquitin-protein ligase activity

Biological Process: entry of virus into host cell; negative regulation of protein transport; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of transporter activity; proteasomal ubiquitin-dependent protein catabolic process; protein autoubiquitination; protein modification process; protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process; regulation of membrane potential

Research Articles on WWP2

1. majority of ovarian carcinomas harbored homozygous or heterozygous deletions in WWP2 locus, and there was an inverse correlation in the expression levels between WWP2 and Notch3 in ovarian carcinomas

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with WWP2 cdna clone

Products by Pathway	Pathway Diagram
Ubiquitin Mediated Proteolysis Pathway antibodies	Ubiquitin Mediated Proteolysis Pathway Diagram
Ubiquitin Mediated Proteolysis Pathway antibodies	Ubiquitin Mediated Proteolysis Pathway Diagram

Diseases associated with WWP2 cdna clone

Disease Name	Pubmed Publications
Death Antibodies	>4 publications with WWP2 and Death
Kidney Diseases Antibodies	>3 publications with WWP2 and Kidney Diseases
Neoplasms, Experimental Antibodies	>2 publications with WWP2 and Neoplasms, Experimental
Congenital Abnormalities Antibodies	>2 publications with WWP2 and Congenital Abnormalities
Carcinoma Antibodies	>2 publications with WWP2 and Carcinoma
Immune System Diseases Antibodies	>1 publications with WWP2 and Immune System Diseases
Edema Antibodies	>1 publications with WWP2 and Edema
Neoplasm Metastasis Antibodies	>1 publications with WWP2 and Neoplasm Metastasis
Carcinoma, Hepatocellular Antibodies	>1 publications with WWP2 and Carcinoma, Hepatocellular
Liver Neoplasms Antibodies	>1 publications with WWP2 and Liver Neoplasms

Organs/Tissues associated with WWP2 cdna clone

Organ/Tissue Name	Pubmed Publications
Kidney Antibodies	>5 publications with WWP2 and Kidney
Blood Antibodies	>4 publications with WWP2 and Blood
Embryonic Tissue Antibodies	>4 publications with WWP2 and Embryonic Tissue
Lung Antibodies	>3 publications with WWP2 and Lung
Connective Tissue Antibodies	>3 publications with WWP2 and Connective Tissue
Brain Antibodies	>3 publications with WWP2 and Brain
Liver Antibodies	>2 publications with WWP2 and Liver
Vascular Antibodies	>2 publications with WWP2 and Vascular
Bone Antibodies	>2 publications with WWP2 and Bone
Prostate Antibodies	>1 publications with WWP2 and Prostate