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ADORA2B Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS244415

The A2b Adenosine Receptor is a target of theophylline and enprofylline in the treatment of asthma. In lung mast cells, A2b receptors are associated with the release of inflammatory mediators. They can also bind the axonal chemoattractant netrin-1 (Corset et… More details

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Product Overview

Online Datasheet in PDF
Product Name
ADORA2B/Adenosine A2B Receptor, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human ADORA2B/Adenosine A2B Receptor
Product Gene Name
anti-ADORA2B antibody
Product Synonym Names
Anti-ADORA2B/Adenosine A2B Receptor Antibody (Internal) IHC-plus; ADORA2; A2b receptor; Adenosine A2b receptor; Adenosine a2b; Adenosine receptor A2b; A2b adenosine receptor; Human ADORA2B/Adenosine A2B Receptor
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Gibbon, Gorilla, Human
Predicted Reactivity: Monkey, Horse (at least 90% immunogen sequence identity)
Form/Format
PBS, 0.1% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human Adenosine A2b Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Molecular Weight
36,333 Da
OMIM
600446
3D Structure
ModBase 3D Structure for P29275
Target Species
Human
Immunogen Description
Synthetic 16 amino acid peptide from internal region of human Adenosine A2b Receptor. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon (100%); Monkey, Marmoset, Horse (94%); Rabbit (88%); Dog (81%).
Immunogen Type
Synthetic peptide
Immunogen
ADORA2B/Adenosine A2B Receptor antibody was raised against synthetic 16 amino acid peptide from internal region of human Adenosine A2b Receptor. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon (100%); Monkey, Marmoset, Horse (94%); Rabbit (88%); Dog (81%).
Antigen Modification
Internal

Product Categories/Family for anti-ADORA2B antibody

Family: GPCR; Subfamily: Adenosine
Applications Tested/Suitable for anti-ADORA2B antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-ADORA2B antibody
IHC-P (10 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after proteinase K antigen retrieval. After incubation with the primary antibody, slides were incubate...

Immunohistochemistry (IHC) of anti-ADORA2B antibody

Anti-Adenosine A2b Receptor antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-ADORA2B Polyclonal Antibody – Cat# MBS244415

Immunohistochemistry (IHC) of anti-ADORA2B antibody

Anti-Adenosine A2b Receptor antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-ADORA2B Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS244415

Other Notes

Small volumes of anti-ADORA2B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ADORA2B purchase

MBS244415 is an antibody targeting ADORA2B. Also known as Rabbit Polyclonal to Human ADORA2B/Adenosine A2B Receptor. Reactive in Gibbon, Gorilla, Human
Predicted Reactivity: Monkey, Horse (at least 90% immunogen sequence identity). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ADORA2B. It may not necessarily be applicable to this product.

NCBI GI #
4501951
NCBI GeneID
136
NCBI Accession #
NP_000667.1
UniProt Primary Accession #
P29275
UniProt Related Accession #
P29275
GenBank Nucleotide #
NM_000676.2
NCBI Official Full Name
adenosine receptor A2b
NCBI Official Synonym Full Names
adenosine A2b receptor
NCBI Official Symbol
ADORA2B
NCBI Official Synonym Symbols
ADORA2
UniProt Protein Name
Adenosine receptor A2b
Protein Family
Adenosine receptor
UniProt Gene Name
ADORA2B
UniProt Entry Name
AA2BR_HUMAN
NCBI Protein Information
adenosine receptor A2b

NCBI Summary for ADORA2B

This gene encodes an adenosine receptor that is a member of the G protein-coupled receptor superfamily. This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation. The gene is located near the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
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UniProt Comments for ADORA2B

ADORA2B: Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; GPCR, family 1; Receptor, GPCR; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 17p12

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: adenosine receptor activity, G-protein coupled

Biological Process: relaxation of vascular smooth muscle; activation of MAPK activity; adenylate cyclase activation; positive regulation of interleukin-6 production; positive regulation of mast cell degranulation; positive regulation of guanylate cyclase activity; excretion; G-protein signaling, adenylate cyclase activating pathway; positive regulation of chemokine production; G-protein coupled receptor protein signaling pathway; positive regulation of chronic inflammatory response to non-antigenic stimulus; cellular response to extracellular stimulus; cellular defense response; JNK cascade; adenosine receptor signaling pathway
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Research Articles on ADORA2B

1. Data indicate adenosine receptor ADORA2B as the specific receptor and signalling pathway for the metabolite 5'-methylthioadenosine (MTA).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ADORA2B antibody

 Reference Product  PubMed Publications
 ADCY9 antibody  >1 publications with ADORA2B and ADCY9
 MYB antibody  >1 publications with ADORA2B and MYB
 DRD5 antibody  >1 publications with ADORA2B and DRD5
 DRD1 antibody  >1 publications with ADORA2B and DRD1
 ADM antibody  >1 publications with ADORA2B and ADM

Pathways associated with anti-ADORA2B antibody

 Products by Pathway  Pathway Diagram
 Adenosine P1 Receptors Pathway antibodies  Adenosine P1 Receptors Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram

Diseases associated with anti-ADORA2B antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >18 publications with ADORA2B and Inflammation
 Cardiovascular Diseases Antibodies  >11 publications with ADORA2B and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >7 publications with ADORA2B and Disease Models, Animal
 Nervous System Diseases Antibodies  >6 publications with ADORA2B and Nervous System Diseases
 Hypertension Antibodies  >6 publications with ADORA2B and Hypertension
 Kidney Diseases Antibodies  >5 publications with ADORA2B and Kidney Diseases
 Edema Antibodies  >2 publications with ADORA2B and Edema
 Pneumonia Antibodies  >2 publications with ADORA2B and Pneumonia
 Proteinuria Antibodies  >2 publications with ADORA2B and Proteinuria
 Fibrosis Antibodies  >2 publications with ADORA2B and Fibrosis

Organs/Tissues associated with anti-ADORA2B antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >18 publications with ADORA2B and Blood
 Lung Antibodies  >9 publications with ADORA2B and Lung
 Heart Antibodies  >6 publications with ADORA2B and Heart
 Brain Antibodies  >6 publications with ADORA2B and Brain
 Intestine Antibodies  >3 publications with ADORA2B and Intestine
 Eye Antibodies  >3 publications with ADORA2B and Eye
 Stomach Antibodies  >2 publications with ADORA2B and Stomach
 Ascites Antibodies  >1 publications with ADORA2B and Ascites
 Prostate Antibodies  >1 publications with ADORA2B and Prostate
 Placenta Antibodies  >1 publications with ADORA2B and Placenta
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