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CIB2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS244842

The deduced amino acid sequence of KIP2 is similar to that of KIP/CIB (46% identity, 64% similarity), calcineurin B (39% identity, 56% similarity) and calmodulin (30% identity, 42% similarity). This suggests that KIP2 may possibly be a Ca2+-binding regulatory… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
CIB2 / KIP2, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal (IgG) to Human CIB2 / KIP2
Product Gene Name
Product Synonym Gene Name
KIP2
Product Synonym Names
Anti-CIB2 / KIP2 Antibody (aa21-70) IHC-plus; CIB2; KIP2; Kinase-interacting protein 2; USH1J; DFNB48; KIP 2; Human CIB2; KIP2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
CIB2 Antibody detects endogenous levels of total CIB2 protein.
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
Molecular Weight
15,816 Da
OMIM
phenotype 614869
3D Structure
ModBase 3D Structure for O75838
Target Species
Human
Immunogen Description
Synthetic peptide from human CIB2 (aa21-70).
Immunogen
CIB2 / KIP2 antibody was raised against synthetic peptide from human CIB2 (aa21-70).
Antigen Modification
aa21-70
Applications Tested/Suitable for anti-CIB2 antibody
Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
Application Notes for anti-CIB2 antibody
ELISA (1:5000), IHC-P (10 ug/ml)

Immunohistochemistry (IHC) of anti-CIB2 antibody

Anti-CIB2 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Rabbit Anti-CIB2 Polyclonal Antibody – Cat# MBS244842

Immunohistochemistry (IHC) of anti-CIB2 antibody

Anti-CIB2 antibody IHC of human adrenal medulla. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Rabbit Anti-CIB2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS244842

Immunohistochemistry (IHC) of anti-CIB2 antibody

Anti-CIB2 antibody IHC of human thyroid, c-cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Rabbit Anti-CIB2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS244842

Other Notes

Small volumes of anti-CIB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CIB2 purchase

MBS244842 is an antibody targeting CIB2. Also known as Rabbit Polyclonal (IgG) to Human CIB2 / KIP2. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CIB2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
calcium and integrin-binding family member 2 isoform 1
NCBI Official Synonym Full Names
calcium and integrin binding family member 2
NCBI Official Symbol
CIB2
NCBI Official Synonym Symbols
KIP2; USH1J; DFNB48
UniProt Protein Name
Calcium and integrin-binding family member 2
UniProt Synonym Protein Names
Kinase-interacting protein 2; KIP 2
UniProt Gene Name
CIB2
UniProt Synonym Gene Names
KIP2; KIP 2
UniProt Entry Name
CIB2_HUMAN
NCBI Protein Information
calcium and integrin-binding family member 2; DNA-dependent protein kinase catalytic subunit-interacting protein 2

NCBI Summary for CIB2

The protein encoded by this gene is similar to that of KIP/CIB, calcineurin B, and calmodulin. The encoded protein is a calcium-binding regulatory protein that interacts with DNA-dependent protein kinase catalytic subunits (DNA-PKcs), and it is involved in photoreceptor cell maintenance. Mutations in this gene cause deafness, autosomal recessive, 48 (DFNB48), and also Usher syndrome 1J (USH1J). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
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UniProt Comments for CIB2

CIB2: Critical for proper photorecetor cell maintenance and function. May play a role in calcium homeostasis and participate in calcium regulation in the mechanotransduction process

Protein type: Calcium-binding

Chromosomal Location of Human Ortholog: 15q24

Cellular Component: muscle tendon junction; photoreceptor inner segment; neuromuscular junction; sarcolemma

Molecular Function: integrin binding; protein binding; calcium ion binding

Biological Process: calcium ion homeostasis; photoreceptor cell maintenance

Disease: Deafness, Autosomal Recessive 48; Usher Syndrome, Type Ij
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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