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p84 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS245087

MBS245087 is an antibody targeting p84. Also known as Mouse Monoclonal [clone 5E10] (IgG2b) to Human p84 / THOC1. Reactive in Human. Host: Mouse. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
p84 / THOC1, Monoclonal Antibody
Full Product Name
Mouse Monoclonal [clone 5E10] (IgG2b) to Human p84 / THOC1
Product Gene Name
anti-p84 antibody
Product Synonym Gene Name
THOC1
Product Synonym Names
Anti-p84 / THOC1 Antibody (aa15-374, clone 5E10) IHC-plus; THOC1; HTREX84; Nuclear matrix protein p84; p84; THO complex subunit 1; THO1; HPR1; p84N5; THO complex 1; Human p84; THOC1
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
5E10
Host
Mouse
Species Reactivity
Human
Form/Format
PBS, pH 7.4. Contains no preservatives.
Purity/Purification
Protein G Purified
Concentration
1 mg/ml (lot specific)
Specificity
Amino acids 15-374 of human p84 expressed in E Coli.
Preparation and Storage
Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.
Molecular Weight
43,359 Da
OMIM
606930
3D Structure
ModBase 3D Structure for Q96FV9
Target Species
Human
Immunogen Description
Recombinant human THOC1.
Immunogen Type
Recombinant protein
Immunogen
p84 / THOC1 antibody was raised against recombinant human THOC1.
Antigen Modification
aa15-374
Applications Tested/Suitable for anti-p84 antibody
Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB), Immunoprecipitation (IP)
Application Notes for anti-p84 antibody
IF, IHC-P (5 ug/ml), IP, WB
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-p84 antibody

Anti-THOC1 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Mouse Anti-p84 Monoclonal Antibody – Cat# MBS245087

Other Notes

Small volumes of anti-p84 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for p84. It may not necessarily be applicable to this product.

NCBI GI #
154448890
NCBI GeneID
9984
NCBI Accession #
NP_005122.2
UniProt Primary Accession #
Q96FV9
UniProt Secondary Accession #
Q15219; Q64I72; Q64I73; B2RBP6
UniProt Related Accession #
Q96FV9
GenBank Nucleotide #
NM_005131.2
NCBI Official Full Name
THO complex subunit 1
NCBI Official Synonym Full Names
THO complex 1
NCBI Official Symbol
THOC1
NCBI Official Synonym Symbols
P84; HPR1; P84N5
UniProt Protein Name
THO complex subunit 1
UniProt Synonym Protein Names
Nuclear matrix protein p84; p84N5; hTREX84
UniProt Gene Name
THOC1
UniProt Synonym Gene Names
HPR1; Tho1; p84N5
UniProt Entry Name
THOC1_HUMAN
NCBI Protein Information
THO complex subunit 1; tho1; hTREX84; nuclear matrix protein p84

NCBI Summary for p84

HPR1 is part of the TREX (transcription/export) complex, which includes TEX1 (MIM 606929), THO2 (MIM 300395), ALY (MIM 604171), and UAP56 (MIM 142560).[supplied by OMIM, Nov 2010]

UniProt Comments for p84

Tho1: a protein associated the nuclear matrix. Part of the TREX (transcription/export) complex. The TREX complex is recruited to transcribed genes and travels with the RNA polymerase during elongation. It may physically link proteins that function in transcription and in RNA export.

Protein type: Spliceosome

Chromosomal Location of Human Ortholog: 18p11.32

Cellular Component: nucleoplasm; intercellular bridge; nuclear matrix; cytoplasm; nuclear speck; nucleus

Molecular Function: protein binding; DNA binding; RNA binding

Biological Process: RNA processing; mRNA export from nucleus; transcription, DNA-dependent; negative regulation of isotype switching to IgA isotypes; apoptosis; RNA splicing; positive regulation of RNA elongation; regulation of DNA recombination; intronless viral mRNA export from host nucleus; signal transduction; mRNA processing; regulation of RNA elongation; replication fork processing
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Research Articles on p84

1. This suggests NEDD4-1 functions in conjunction with other post-translational mechanisms to regulate Thoc1 protein and THO activity.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-p84 antibody

 Reference Product  PubMed Publications
 THOC5 antibody  >2 publications with p84 and THOC5
 THOC6 antibody  >1 publications with p84 and THOC6
 THOC2 antibody  >1 publications with p84 and THOC2
 THOC7 antibody  >1 publications with p84 and THOC7

Pathways associated with anti-p84 antibody

 Products by Pathway  Pathway Diagram
 RNA Transport Pathway antibodies  RNA Transport Pathway Diagram
 RNA Transport Pathway antibodies  RNA Transport Pathway Diagram
 Spliceosome Pathway antibodies  Spliceosome Pathway Diagram
 Spliceosome Pathway antibodies  Spliceosome Pathway Diagram
 THC Complex Pathway antibodies  THC Complex Pathway Diagram
 THC Complex Pathway antibodies  THC Complex Pathway Diagram
 TREX Complex Pathway antibodies  TREX Complex Pathway Diagram
 TREX Complex Pathway antibodies  TREX Complex Pathway Diagram

Diseases associated with anti-p84 antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >4 publications with p84 and Breast Neoplasms
 Neoplasm Metastasis Antibodies  >3 publications with p84 and Neoplasm Metastasis
 Lung Neoplasms Antibodies  >3 publications with p84 and Lung Neoplasms
 Adenocarcinoma Antibodies  >2 publications with p84 and Adenocarcinoma
 Ovarian Diseases Antibodies  >2 publications with p84 and Ovarian Diseases
 Pancreatic Neoplasms Antibodies  >2 publications with p84 and Pancreatic Neoplasms
 Carcinoma, Squamous Cell Antibodies  >1 publications with p84 and Carcinoma, Squamous Cell
 Infertility, Male Antibodies  >1 publications with p84 and Infertility, Male
 Infertility, Female Antibodies  >1 publications with p84 and Infertility, Female
 Necrosis Antibodies  >1 publications with p84 and Necrosis

Organs/Tissues associated with anti-p84 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >3 publications with p84 and Lung
 Bone Marrow Antibodies  >2 publications with p84 and Bone Marrow
 Embryonic Tissue Antibodies  >2 publications with p84 and Embryonic Tissue
 Bone Antibodies  >2 publications with p84 and Bone
 Testis Antibodies  >2 publications with p84 and Testis
 Kidney Antibodies  >1 publications with p84 and Kidney
 Prostate Antibodies  >1 publications with p84 and Prostate
 Blood Antibodies  >1 publications with p84 and Blood
 Bladder Antibodies  >1 publications with p84 and Bladder
 Liver Antibodies  >1 publications with p84 and Liver
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