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AKR1B10 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS245533

MBS245533 is an antibody targeting AKR1B10. Also known as Mouse Monoclonal [clone 1A6] (IgG2a,k) to Human AKR1B10. Reactive in Human. Host: Mouse. More details

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Product Overview

Product Name
AKR1B10, Monoclonal Antibody
Full Product Name
Mouse Monoclonal [clone 1A6] (IgG2a,k) to Human AKR1B10
Product Gene Name
anti-AKR1B10 antibody
Product Synonym Names
Anti-AKR1B10 Antibody (clone 1A6) IHC-plus; AKR1B10; AKR1B11; Aldose reductase-like peptide; ALDRLn; AKR1B12; Aldose reductase-like; Aldose reductase-like 1; ARP; HARP; HSI; Small intestine reductase; ARL-1; SI reductase; Human AKR1B10
Clonality
Monoclonal
Isotype
IgG2a,k
Clone Number
1A6
Host
Mouse
Species Reactivity
Human
Form/Format
PBS, pH 7.2. Sourced in Ascites.
Purity/Purification
Protein A Purified
Concentration
0.5 mg/ml (lot specific)
Preparation and Storage
Store at -20 degree C. Aliquot to avoid freeze/thaw cycles.
Molecular Weight
36,020 Da
OMIM
604707
3D Structure
ModBase 3D Structure for O60218
Target Species
Human
Immunogen Description
AKR1B10 (NP_064695, 76 a.a. ~ 144 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Immunogen Type
Recombinant protein
Immunogen
AKR1B10 antibody was raised against aKR1B10 (NP_064695, 76 a.a. ~ 144 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Applications Tested/Suitable for anti-AKR1B10 antibody
Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB), ELISA (EIA)
Application Notes for anti-AKR1B10 antibody
ELISA, IF (10 ug/ml), IHC-P (5 ug/ml), WB
Usage: Western Blot (Cell lysate) - positive control HepG2. Immunofluorescence (10 ug/ml) - positive control HeLa cells. Sandwich ELISA (Recombinant protein).

Immunohistochemistry (IHC) of anti-AKR1B10 antibody

Anti-AKR1B10 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Mouse Anti-AKR1B10 Monoclonal Antibody – Cat# MBS245533

Immunohistochemistry (IHC) of anti-AKR1B10 antibody

Anti-AKR1B10 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Mouse Anti-AKR1B10 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS245533

Immunohistochemistry (IHC) of anti-AKR1B10 antibody

Anti-AKR1B10 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Mouse Anti-AKR1B10 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS245533

Immunofluorescence (IF) of anti-AKR1B10 antibody

Immunofluorescence of monoclonal antibody to AKR1B10 on HeLa cell (antibody concentration 10 ug/ml).
Mouse Anti-AKR1B10 Monoclonal Antibody, Immunofluorescence (IF) – Cat# MBS245533

Western Blot (WB) of anti-AKR1B10 antibody

AKR1B10 monoclonal antibody, clone 1A6 Western blot of AKR1B10 expression in HepG2.
Mouse Anti-AKR1B10 Monoclonal Antibody, Western Blot (WB) – Cat# MBS245533

ELISA (EIA) of anti-AKR1B10 antibody

Detection limit for recombinant GST tagged AKR1B10 is approximately 0.03 ng/ml as a capture antibody.
Mouse Anti-AKR1B10 Monoclonal Antibody, ELISA (EIA) – Cat# MBS245533

Other Notes

Small volumes of anti-AKR1B10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for AKR1B10. It may not necessarily be applicable to this product.

NCBI GI #
223468663
NCBI GeneID
57016
NCBI Accession #
NP_064695.3
UniProt Primary Accession #
O60218
UniProt Secondary Accession #
O75890; Q6FHF3; Q8IWZ1; A4D1P1
UniProt Related Accession #
O60218
GenBank Nucleotide #
NM_020299.4
NCBI Official Full Name
aldo-keto reductase family 1 member B10
NCBI Official Synonym Full Names
aldo-keto reductase family 1, member B10 (aldose reductase)
NCBI Official Symbol
AKR1B10
NCBI Official Synonym Symbols
HIS; HSI; ARL1; ARL-1; ALDRLn; AKR1B11; AKR1B12
UniProt Protein Name
Aldo-keto reductase family 1 member B10
UniProt Synonym Protein Names
ARL-1; Aldose reductase-like; Aldose reductase-related protein; ARP; hARP; Small intestine reductase; SI reductase
Protein Family
Aldo-keto reductase family
UniProt Gene Name
AKR1B10
UniProt Synonym Gene Names
AKR1B11; ARP; hARP; SI reductase
UniProt Entry Name
AK1BA_HUMAN
NCBI Protein Information
aldo-keto reductase family 1 member B10; ARP; hARP; SI reductase; aldose reductase-like 1; small intestine reductase; aldose reductase-like peptide; aldose reductase-related protein; aldo-keto reductase family 1, member B11 (aldose reductase-like)

NCBI Summary for AKR1B10

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis. [provided by RefSeq, Jul 2008]
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UniProt Comments for AKR1B10

AKR1B10: Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. Belongs to the aldo/keto reductase family.

Protein type: EC 1.1.1.-; Carbohydrate Metabolism - fructose and mannose; Oxidoreductase; Carbohydrate Metabolism - butanoate; EC 1.1.1.21; Lipid Metabolism - linoleic acid

Chromosomal Location of Human Ortholog: 7q33

Cellular Component: lysosome; cytosol

Molecular Function: protein binding; aldo-keto reductase activity; indanol dehydrogenase activity; geranylgeranyl reductase activity; retinal dehydrogenase activity

Biological Process: steroid metabolic process; phototransduction, visible light; digestion; farnesol catabolic process; aldehyde metabolic process; retinoid metabolic process
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Research Articles on AKR1B10

1. AKR1B10 may have an important role in the development and progression of diabetic nephropathy.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-AKR1B10 antibody

 Reference Product  PubMed Publications
 ALDH3A1 antibody  >5 publications with AKR1B10 and ALDH3A1
 GPX2 antibody  >3 publications with AKR1B10 and GPX2
 CBR1 antibody  >1 publications with AKR1B10 and CBR1
 EGF antibody  >1 publications with AKR1B10 and EGF
 CBR3 antibody  >1 publications with AKR1B10 and CBR3

Pathways associated with anti-AKR1B10 antibody

 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Associated With Visual Transduction Pathway antibodies  Diseases Associated With Visual Transduction Pathway Diagram
 Fructose And Mannose Metabolism Pathway antibodies  Fructose And Mannose Metabolism Pathway Diagram
 Fructose And Mannose Metabolism Pathway antibodies  Fructose And Mannose Metabolism Pathway Diagram
 Galactose Metabolism Pathway antibodies  Galactose Metabolism Pathway Diagram
 Galactose Metabolism Pathway antibodies  Galactose Metabolism Pathway Diagram
 Glycerolipid Metabolism Pathway antibodies  Glycerolipid Metabolism Pathway Diagram
 Glycerolipid Metabolism Pathway antibodies  Glycerolipid Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Pentose And Glucuronate Interconversions Pathway antibodies  Pentose And Glucuronate Interconversions Pathway Diagram

Diseases associated with anti-AKR1B10 antibody

 Disease Name  Pubmed Publications
 Carcinoma, Hepatocellular Antibodies  >24 publications with AKR1B10 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >21 publications with AKR1B10 and Liver Neoplasms
 Lung Neoplasms Antibodies  >20 publications with AKR1B10 and Lung Neoplasms
 Liver Diseases Antibodies  >19 publications with AKR1B10 and Liver Diseases
 Breast Neoplasms Antibodies  >9 publications with AKR1B10 and Breast Neoplasms
 Colorectal Neoplasms Antibodies  >7 publications with AKR1B10 and Colorectal Neoplasms
 Inflammation Antibodies  >5 publications with AKR1B10 and Inflammation
 Liver Cirrhosis Antibodies  >5 publications with AKR1B10 and Liver Cirrhosis
 Neoplasms, Experimental Antibodies  >5 publications with AKR1B10 and Neoplasms, Experimental
 Fatty Liver Antibodies  >5 publications with AKR1B10 and Fatty Liver

Organs/Tissues associated with anti-AKR1B10 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >38 publications with AKR1B10 and Lung
 Liver Antibodies  >37 publications with AKR1B10 and Liver
 Intestine Antibodies  >7 publications with AKR1B10 and Intestine
 Stomach Antibodies  >5 publications with AKR1B10 and Stomach
 Uterus Antibodies  >4 publications with AKR1B10 and Uterus
 Kidney Antibodies  >4 publications with AKR1B10 and Kidney
 Eye Antibodies  >3 publications with AKR1B10 and Eye
 Esophagus Antibodies  >2 publications with AKR1B10 and Esophagus
 Skin Antibodies  >2 publications with AKR1B10 and Skin
 Brain Antibodies  >2 publications with AKR1B10 and Brain
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